CAS: 34698-41-4; 2,3-Dihydro-1H-Inden-1-Amine

上下游产品

1-chloroindane 3,4-dimercaptotoluene 1-isothi°Cyanatoindane indan-1-one oxime N-(2,3-dihydro-1H-inden-1-yl)acetamide (+)-N-benzylindan-1-amine benzyl-indan-1-yl-amine; hydr°Chloride (S)-1-Aminoindane

2,3-二氢-1H-茚-1-醇置于ammonium Hydroxide,C15H29Irn4(2+)*2I(1-)体系中,化学反应 40.0H,以83%的收率获得1-氨基茚满
参考文献:铱的水溶性n-杂环碳烯配合物催化的氨与醇的n-烷基化反应生成伯胺
标题:铱的水溶性n-杂环碳烯配合物催化的氨与醇的n-烷基化反应生成伯胺
摘要:开发了一种新的催化体系,用于氨水与多种醇的n-单烷基化.带有铱的n杂环卡宾和二胺配体的水溶性双金属络合物在氢转移过程的基础上对这种类型的反应表现出高催化活性,而不会产生有害或浪费的副产物.通过使用安全,廉价且易于处理的氨水作为氮源,可以有效地合成各种伯胺.例如,1-(4-甲基苯基)乙醇与氨水在铱的水溶性n-杂环卡宾配合物的存在下在150oc下反应40小时,在83中得到1-(4-甲基苯基)乙胺% 屈服.
Doi:10.1002/cctc.201702037

专利信息

专利号:US-8901352-B2
优先权日:2011-01-13
标题 :Method for the synthesis of rasagiline
发明人：REIS ÖMER; KOYUNCU HASAN; ESIRINGU ILKER; SAHIN YASEMIN; GULCAN H OZAN
权利人:REIS ÖMER; KOYUNCU HASAN; ESIRINGU ILKER; SAHIN YASEMIN; GULCAN H OZAN; NOBEL ILAÇ SANAYII VE TICARET A S
摘要:We have developed a new method for the synthesis of Rasagiline (Formula 1) based on the alkylation of trifluoroacetyl protected aminoindan. This protection enabled us to carry out an alkylation of aminoindan with a high yield and purity under very mild conditions with a wide range of reaction conditions and reagent selection. Considering the ease, purity and high yields of introducing and removal of the trifluoroacetyl group, this approach is a highly practical and economical way for the synthesis of rasagiline or its pharmaceutically acceptable salts.

专利号:WO-0140193-A1
优先权日:1999-12-03
标题:Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:US-2002103381-A1
优先权日:2000-11-30
标 题 :Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula I: n n n Also claimed are novel intermediates and their methods of synthesis.

专利号:US-8084630-B2
优先权日:2007-05-31
标 题 :Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL; TEVA PHARMA
摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.

专利号:US-10059653-B2
优先权日:2015-01-20
标 题 :Process for the preparation of indanamine derivatives and new synthesis intermediates
发明人：BERTOLINI GIORGIO; CEREA PAOLANGELO; COLLI CORRADO; FELICIANI LAZZARO; GASSA FEDERICO; BIANCHI ALDO; COLOMBO FEDERICA; MAIORANA STEFANO; NISIC FILIPPO
权利人:LABORATORIO CHIMICO INT S P A; OLON SPA
摘要:Subject-matter of the invention is a process for the preparation of a key intermediate in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates. Formula (I):