CAS: 4368-28-9; Tetrodotoxin

上下游产品

CAS号588693-73-6 (E)-2-((2R,5S,6... | CAS号588693-71-4 (1S,4R,6R,E)-4-... | CAS号588693-75-8 methyl (E)-2-((... | CAS号588693-98-5 ((1S,2R,3S,4R,5... | CAS号588693-55-4 (1S,3S,5R,8S,8a... | CAS号588693-65-6 (1S,5R,8S,8aR)-... | CAS号588693-96-3 ((1S,2R,3S,4R,5... | CAS号588693-79-2 methyl 2-((1S,5... | CAS号588693-60-1 (1S,5R,8S,8aR)-... | CAS号3270-35-7 Tetrodonic acid | CAS号73600-89-2 3-Amino-5,9,12,...

专利信息

专利号:US-2023312596-A1
优先权日:2020-07-20
标题:Method for large-scale synthesis of tetrodotoxin
发明人：WANG GUANGYIN; LI XIAOMING; WANG CHENGXI; HUANG PING; BAI HUA; LAI LIANG; GUO PENG; JIANG BIAO; ZHU WENFENG
权利人:SHANGHAI SHENGPING MEDICAL EQUIPMENT CO LTD; SHANGHAI VASTPRO TECH DEVELOPMENT CO LTD; ZHEJIANG BOXIAO BIOPARMACEUTICAL CO LTD
摘要:The present invention provides a method for biological and chemical synthesis of tetrodotoxin, specifically comprising the following steps: using cheap and easily available benzyl acetate as a raw material, and performing biological fermentation to obtain an optically pure intermediate ((5S, 6R)-5, 6-dihydroxycyclohexa-1, 3-dienyl) methyl acetate (formula I); and performing a series of chemical conversions on the intermediate to finally obtain tetrodotoxin at a purity of 95% or more without purifying the product. The present invention has the potential of large-scale production, and is an excellent alternative to the existing extraction method from a pufferfish.

专利号:US-5288870-A
优先权日:1991-11-18
标题:Synthesis of specifically labeled tetrodotoxin
发明人：KAO CHIEN-YUAN; WU BIQI
权利人:UNIV NEW YORK STATE RES FOUND
摘要:The present invention relates to a process for the preparation of specifically labelled TTX of high specific activity. In the present process, TTX is oxidized by use of the Pfitzer-Moffat method or Fenton's reagent and the aldehyde obtained is hydrated. The hydrated aldehyde is reduced with alkali metal o alkaline earth metal borotritide. The radioactive TTX so obtained, quite surprisingly, has a specific activity many times greater than previously prepared radioactive TTX.

专利号:WO-2022256660-A1
优先权日:2021-06-04
标 题:Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
发明人：HARRISON CRISTIAN
权利人:VERTEX PHARMA
摘要:Provided in this application is a process for making Compound I (I) and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels. Processes for making various intermediate products, and suitable salts thereof, are also provided.

专利号:US-2024335442-A1
优先权日:2021-08-02
标 题:N-acylhydrazone compounds capable of inhibiting nav1.7 and/or nav1.8, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; GAMBA LUIS EDUARDO REINA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA; LIMA LÃ?DIA MOREIRA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO UFRJ
摘要:N-acylhydrazone compounds that are Nav 1.7 and/or Nav 1.8 inhibitors, including N-acylhydrazone compounds of Formula (I), wherein the substituents R1 to R6 are independently selected from the groups defined in the specification, as well as to the processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits, and which are applicable in the fields of medicinal chemistry and organic synthesis, as well as in the treatment of pain-related disorders.

专利号:US-2009022739-A1
优先权日:2005-08-03
标题 :MODULATING THE KV1.1 VOLTAGE-GATED POTASSIUM CHANNEL IN T-CELLS FOR REGULATING THE SYNTHESIS AND SECRETION OF TUMOR NECROSIS FACTOR ALPHA (tnf-ALPHA) AND TREATING HUMAN DISEASE OR INJURIES MEDIATED BY DETRIMENTALLY HIGH OR LOW LEVELS OF TNF-ALPHA
发明人：LEVITE MIA
权利人:LEVITE MIA
摘要:Blocking the voltage-gated potassium channel Kv1.1 of T-cells causes the robust and exclusive production of TNF-α, and thus can be used for eradication of cancer, improved eradication of infectious organisms, increased permeability of blood vessels and the blood brain barriers to given molecules and cells, and improved neuronal features, regeneration function and development. Blocking the voltage-gated potassium channel Kv1.1 of T-cells causes the robust and exclusive production of TNF-α. Similarly, unblocking of a blocked Kv1.1 channel or opening of a Kv1.1 channel will prevent the T-cells from producing and secreting excess amounts of TNF-α, thus being useful in the treatment of conditions such as rheumatoid arthritis and for treating neurological diseases associated with defected functioning and/or pathological block of the Kv1.1 channel, among them PNH associated with Kv1 Abs; Encephalitis associated with Kv1 Abs; and Episodic-ataxia type 1 (EA-1), in all of which the T-cell blocked Kv1.1 channel may secrete excess TNFa and thereby contribute to the pathology. Blocking of the Kv1.1 channel may be achieved in vivo or ex vivo by contact with a selective Kv1.1 channel blocking molecule such as Dendrotoxin-K or a selective monoclonal antibody against the Kv1.1 channel. Preventing the Kv1.1. block would be achieved by Kv1.1 openers, or by molecules that would prevent the closure of the Kv1.1 channel.

专利号:US-6245919-B1
优先权日:1996-06-28
标 题:Cyclopropylglycine derivatives and agonists for metabotronic L-glutamate receptors
发明人：SHINOZAKI HARUHIKO; TAGUCHI TAKEO; ISHIDA MICHIKO
权利人:SHINOZAKI HARUHIKO; TAGUSHI TAKEO; NIPPON CHEMIPHAR CO
摘要:A cyclopropylglycine derivative having the following formula:and an intermediate compound for the synthesis of the cyclopropylglycine derivative are novel compounds. The cyclopropylglycine derivative shows a selectivity higher than that of the known agonists to metabotropic L-glutamate receptors, and therefore is a metabotropic type agonist to L-glutamate which has excellent characteristics.