CAS: 588-43-2; Tributoxymethane

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orthoformic acid triethyl ester butan-1-ol iodoform chloroformn-Butyl chloride n-butyl formate benzoic acid, butyl ester dibutyl acetal

氢氰酸,正丁醇置于盐酸体系中,用 Mineral Oil,正丁醇 作为反应溶剂,化学反应 6.33H,以74.06%的收率获得产物原甲酸三正丁基酯
参考文献:制备原甲酸酯的绿色清洁工艺
标题:制备原甲酸酯的绿色清洁工艺
摘要:本发明提供了一种制备原甲酸酯的绿色清洁工艺,可以使用涉氯合成工业的副产氯化氢尾气,制成氯化氢醇溶液缓慢加入反应体系,这样既减少了氢氰酸逸出造成的损失,提高了收率,还避免了这类公司制备副产盐酸带来的巨大设备腐蚀,同时大大增加了副产氯化氢的经济附加值,无三废产生,只是副产氯化铵,做到了资源的合理利用,是环境友好型的生产工艺,所以此工艺有很好的社会效益.

专利信息

专利号:US-11649213-B2
优先权日:2018-09-26
标题 :Synthetic method for the preparation of a 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol compound
发明人：MEISENBACH MARK; MARTIN BENJAMIN; RONDE NIEK JOHANNES; RUIZ CARMEN
权利人:MEREO BIOPHARMA 1 LTD
摘要:Provided is a process for preparing a compound, comprising the steps of a) Reacting a compound of Formula A (Formula A) with the compound 3 (3) to provide the compound 5 (5) or a salt or solvate thereof, wherein R is a linear or branched C1-C5 alkyl. Further provided is the compound 5 or a salt or solvate thereof. (5) The use of these compounds in the synthesis of 3-[5-Amino-4-(3-Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide is also provided.

专利号:US-6953678-B1
优先权日:1999-07-26
标题 :Use of orthoesters for the synthesis of chiral acids in biocatalyzed irreversible esterification processes
发明人：MORRONE RAFFAELE; NICOLOSI GIOVANNI; PIATTELLI MARIO
权利人:CONSIGLIO NAZIONALE RICERCHE
摘要:A process for the resolution of enantiomeric mixtures of a chiral carboxylic acid, including an esterification reaction of the carboxylic acid in an organic solvent, in the presence of a stereoselective hydrolase, characterized in that an orthoester of the formula R 1 —C(OR 2 ) 3 , in which R 1 is selected from H and C 1 –C 4 alkyl and R 2 is C 1 –C 8 alkyl or —CH 2 —C 6-10 aryl, is used as the esterification reactive.

专利号:US-4237055-A
优先权日:1979-06-18
标 题 :Synthesis of 1RS,4SR,5RS-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid
发明人：HAJOS ZOLTAN G; WACHTER MICHAEL P
权利人:ORTHO PHARMA CORP
摘要:A method of synthesizing 1RS,4SR,5RS-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo [3.2.1]octane-1-acetic acid. The acid is a derivative of the natural product zoapatanol, one of the active ingredients in the zoapatle plant, and is active as a utero-evacuant agent.

专利号:US-4990631-A
优先权日:1990-05-30
标 题:Process for the preparation of 2,2-dialkoxy cyclic ortho esters derived from lactones
发明人：ALSTER KAROL
权利人:ALZA CORP
摘要:This invention is directed to a process for the synthesis of 2,2-dialkoxy cyclic ortho esters derived from lactones which comprises reacting trialkyl orthoformate with boron trifluoride to give dialkoxymethylium tetrafluoroborate; reacting dialkoxymethylium tetrafluoroborate with a lactone to give the corresponding O-alkyllactonium tetrafluoroborate; and reacting the O-alkyllactonium tetrafluoroborate with an alkoxide, or alternatively with an alkanol in the presence of a base; wherein the first two steps of the process of the invention are conducted in the absence of solvents, other than the reactants themselves. The third step may also optionally be run without solvents. n The invention is also directed to the preparation of the O-alkyllactonium tetrafluoroborate in one reaction vessel; that is, the boron trifluoride is added to the trialkyl orthoformate and the lactone in a single reaction vessel. As the intermediate dialkoxymethylium tetrafluoroborate is formed, it reacts in situ with the lactone in the reaction mixture, thus avoiding the additional steps of separating the dialkoxymethylium tetrafluoroborate and then reacting it with the lactone in a separate step and vessel.

专利号:US-9919997-B2
优先权日:2013-12-30
标题 :One-pot water-free ionic liquids synthesis using trialkyl orthoesters
发明人：PARK JIN KYOON; KIM DO JOONG; OH KYUNG HWAN
权利人:PUSAN NATIONAL UNIV INDUSTRY UNIV COOPERATION FOUNDATION OF PUSAN
摘要:The present disclosure provides a method for producing an ionic liquid, the method comprising: reacting a nitrogen-containing heterocyclic compound or an amine-based compound with an ammonium salt along with trialkyl orthoformate to acquire an alkylated nitrogen-containing heterocyclic compound or an alkylated nitrogen-containing amine-based compound, wherein the alkylated nitrogen-containing heterocyclic compound or the alkylated nitrogen-containing amine-based compound as a cation of the ionic liquid is ionically bonded to an anion included in the ammonium salt to form the ionic liquid.

专利号:US-4990602-A
优先权日:1986-12-17
标 题:Erythromycin A derivatives
发明人：MORIMOTO SHIGEO; ADACHI TAKASHI; MATSUNAGA TOHRU; KASHIMURA MASATO; ASAKA TOSHIFUMI; WATANABE YOSHIAKI; SOTA KAORU; SEKIUCHI KAZUTO
权利人:TAISHO PHARMACEUTICAL CO LTD
摘要:Erthromycin A derivatives represented by the general formula ##STR1## wherein R 1 is a group of the formula R 7 CH 2 -- (wherein R 7 is a hydrogen group or a lower alkyl group) or a group of the formula R 8 O-- (wherein R 8 is a lower alkyl group), R 2 is R 8 , a cycloalkyl group, a phenyl group or an aralkyl group.), or R 2 and R 7 together form an alkylene group, R 3 is a hydrogen atom, a lower alkyl group, a phenyl group or an aralkyl group, or R 3 and R 7 together form an alkylene group, or R 2 and R 3 together form an alkylene group, R 4 is a lower alkyl group, R 5 is a substituted silyl group, and R 6 is a hydrogen atom or R 5 , are disclosed. These compounds are useful as intermediates for the synthesis of antibacterial agents.