Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于水体系中,化学反应生成 N,N-二乙基甲胺 参考文献:Stewart; Aston,Journal Of The American Chemical Society,1926,Vol. 48,P. 1650 标题:Stewart; Aston,Journal Of The American Chemical Society,1926,Vol. 48,P. 1650
专利号:US-5145957-A 优先权日:1988-03-18 标 题:Stereoselective synthesis of a chiral cis 3-beta hydrogen (3R) 4-aroyloxy azetidinone 发明人:TSCHAEN DAVID M; LYNCH JOSEPH E; LASWELL WILLIAM L; VOLANTE RALPH P; SHINKAI ICHIRO 权利人:MERCK & CO INC 摘要:A process is described for the stereocontrolled synthesis of (3R,4R)-3-[(1R)-1-hydroxyethyl]-4-benzoyloxyazetidin-2-ones and their derivatives by cycloaddition involving an imine and a ketone, generated from 3(S)-hydroxybutyrate which are useful intermediates in the synthesis of carbapenem antibiotics.
专利号:US-8975358-B2 优先权日:2010-07-23 标题 :Compositions and methods for synthesis of organic-silica hybrid materials 发明人:SHEA KENNETH J; HU LI-CHIH 权利人:SHEA KENNETH J; HU LI-CHIH; UNIV CALIFORNIA 摘要:The present invention relates to compositions and methods for synthesis of organic-silica hybrid microparticles and nanoparticles. In particular, the present invention provides compositions and methods for particle size control during synthesis of organic-silica hybrid microparticles and nanoparticles.
专利号:US-9688644-B2 优先权日:2009-04-30 标 题 :Synthesis of Tetracyclines and intermediates thereto 发明人:MYERS ANDREW G; KUMMER DAVID A; LI DERUN; HECKER EVAN; DION AMELIE; WRIGHT PETER M 权利人:HARVARD COLLEGE 摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.
专利号:EP-0269236-B1 优先权日:1986-10-24 标题:Process for synthesis of a chiral azetidinone 摘要:A process is described for the stereo-controlled synthesis of 3-(R)-3-[1'-(R)-hydroxyethyl]-4-(R)-benzoyl-2-oxo-1-aze tidines and their derivatives which are useful intermediates in the synthesis of carbapenem antibiotics.
专利号:EP-0333268-A1 优先权日:1988-03-18 标题:Process for synthesis of a chiral 3-beta hydrogen (3R) 4-aroyloxy azetidinone 发明人:TSCHAEN DAVID M; LYNCH JOSEPH E; LASWELL WILLIAM L; VOLANTE RALPH P; SHINKAI ICHIRO 权利人:MERCK & CO INC 摘要:A process is described for the stereo-Âcontrolled synthesis of (3R,4R)-3-[(1R)-1-hydroxyÂethyl]-4-benzoyloxyazetidin-2-ones and their derivatives which are useful intermediates in the synthesis of carbapenem antibiotics.
专利号:US-6951932-B2 优先权日:2001-10-25 标 题:Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines 发明人:MOORMAN ALLAN R 权利人:KING PHARMACEUTICALS RES & DEV 摘要:The invention provides new methods for synthesis of 2-aralkyloxyadenosines and 2-alkoxyadenosines. The invention is particularly useful for synthesis of 2-[2-(4-chlorophenyl)ethoxy]adenosine. Preferred methods of the invention include activating a guanosine compound followed by hydrolysis; alkylating the hydrolyzed compound with subsequent animation to provide a 2-aralkyloxyadenosine or a 2-alkoxyadenosine compound.
参考标题:Catalytic Hydrogenation Of Amides To Amines Under Mild Conditions 作者:Mario Stein,Bernhard Breit |发布日期:2013.2.18 摘要:Under (Not So Much) Pressure: A General Method For The Hydrogenation Of Tertiary And Secondary Amides To Amines With Excellent Selectivity Using A Bimetallic Pd-Re Catalyst Has Been Developed. The Reaction Proceeds Under Low Pressure And Comparatively Low Temperature. This Method Provides Organic Chemists With A Simple And Reliable Tool For The Synthesis Of Amines.
合成参考文献
摘要:André-Joyaux, E.; Gnägi, L.; Meléndez, C.; Soulard, V.; Renaud, P., Science of Synthesis, (2021) , 459. 参考文献:10.1007/s11030-005-9009-x 摘要:Roy DR, Sarkar U, Chattaraj PK, Mitra A, Padmanabhan J, Parthasarathi R, Subramanian V, Van Damme S, Bultinck P. Analyzing toxicity through electrophilicity. Mol Divers. 2006 May;10(2):119–31. doi: 10.1007/s11030-005-9009-x. 参考文献:10.1385/abab:79:1-3:609 摘要:Holtzapple MT, Davison RR, Ross MK, Aldrett-Lee S, Nagwani M, Lee C, Lee C, Adelson S, Kaar W, Gaskin D, Shirage H, Chang N, Chang VS, Loescher ME. Biomass conversion to mixed alcohol fuels using the MixAlco process. Applied Biochemistry and Biotechnology. 1999 Mar;79(1-3):609–31. doi: 10.1385/abab:79:1-3:609.