CAS: 6415-07-2; Tri(Pyrrolidin-1-yl)Phosphine Oxide

相似化合物

5666-12-6 133894-48-1 132705-51-2

上下游产品

(S)-N-(benzyloxycarbonyl)valine benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 5-bromo-2-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-nicotinic acid dimethyl aminebromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 3(tris(pyrrolidinyl)phosphine oxide)3}{Ph4B}{UCl3(tris(pyrrolidinyl)phosphine oxide)3}{Ph4B}

Bromo-Tris-Pyrrolidino-Phosphonium Hexafluorophosphate置于potassium Hydroxide体系中,化学反应 4.0H,反应生成 三(N,N-四亚甲基)磷酰胺
参考文献:碱性介质中四(二烷基氨基)phosph稳定性的快速分析
标题:碱性介质中四(二烷基氨基)phosph稳定性的快速分析
摘要:氢氧化物稳定的有机阳离子是电化学能量系统中离子迁移过程的关键组成部分,四(二烷基氨基)阳离子是该应用的有希望的候选者.已知这些phospho对碱性介质具有高度的抵抗力.但是,很少有研究系统地评估这些阳离子在氢氧根或醇盐阴离子存在下的分解方式.几种四氨基phosph在2 M Koh / Ch 3中的优异稳定性在80oc的oh下,我们设计了用于快速评估homogeneous在均相溶液中和相转移条件下降解的实验.分析表明,阳离子核心周围的取代基如何影响降解途径和降解速率.在醇溶剂中观测到最常见的降解途径是β-H的消除和对磷原子的直接侵蚀,而在相转移条件下(phcl和50 Wt%naoh / H2O)则观测到α-H的提取和直接侵蚀..收集的数据提供了该阳离子家族的相对稳定性比较,以实现将来的设计改进,并说明了使用多种测试进行降解研究的实用性.
DOI:10.1021/acs.Organomet.7B00663

专利信息

专利号:WO-2025136842-A1
优先权日:2023-12-19
标题 :Process for preparing n-aminoalkylated tryptophan compounds
发明人：CO SARAH S; DALBY STEPHEN M; JOHNSON KEYWAN ALEXANDER; KLAPARS ARTIS; KUETHE JEFFREY T; PETERS BYRON KENNEDY; SIROTA ERIC; WRIGHT TIMOTHY JAMES; XIAO KAIJIONG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to processes useful in the synthesis of aminohexyl compounds, such as a compound of Formula I or a salt, hydrate and/or solvate thereof, as well as methods for the preparing a compound of Formula I and intermediates used to make a compound of Formula I. The present invention presents a novel method for the selective alkylation of tryptophan analogues, eliminating the need for protecting groups and advancing the field of tryptophan analogue synthesis.

专利号:EP-4188934-A1
优先权日:2020-07-25
标 题 :Process for synthesis of organosilicon compounds from halosilanes

专利号:US-7304163-B2
优先权日:2005-08-16
标题:Benzotriazole-1-yl-N-oxy phosphonium coupling agent
发明人：LUXEMBOURG YOAV; SHVO YOUVAL; EWENSON ARIEL
权利人:LUXEMBOURG IND LTD
摘要:Novel phosphonium salts of benzotraizoles, which are highly reactive coupling agents, and are particularly useful in peptide synthesis, are disclosed. Further disclosed is a process of preparing the novel phosphonium salts and methods utilizing same for preparing peptides.