CAS: 67881-98-5; 2-(Methacryloyloxy)Ethyl (2-(Trimethylammonio)Ethyl) Phosphate

该化合物是一种合成化合物,其特征是具有闪光性,结合了盐水和疏水特性,具有磷酰胆碱酯酯酶特性,具有生物兼容性和水益性,适合各种生物医学应用,包括药物交付和组织工程;甲氧基乙基磷酰碱集团允许聚合,能够形成氢凝胶和其他聚合材料;众所周知,聚氯乙烯具有抗蛋白吸附和细胞粘合的能力,有利于减少医疗设备的生物污损;其化学结构有助于其在水环境的稳定性和功能;此外,可与其他单体聚合聚氯乙烯,以调整所产材料的特性,提高它们在具体应用中的性能;

结构式图片

相似化合物

32435-46-4 4235-95-4 26853-31-6

欧盟法规

REACH注册ECHA物质REACH预注册

上下游产品

CAS号82793-19-9 Ethylene 2-(met... | CAS号75-50-3 三甲胺 | CAS号868-77-9 甲基丙烯酸羟乙酯 | CAS号24619-52-1 Ethylenedioxy-2... | CAS号190070-80-5 2-Cyanoethoxy(d...

合成工艺路线路线简述

  • 合成目标产物 2-Methacryloyloxyethyl Phosphorylcholine 主要起始原料 2-Propenoic Acid, 2-Methyl-, 2-[(2-Oxido-1,3,2-Dioxaphospholan-2-yl)Oxy]Ethyl Ester And Trimethylamine
  • (文献来源)合成步骤主要原料 2-Propenoic Acid, 2-Methyl-, 2-[(2-Oxido-1,3,2-Dioxaphospholan-2-yl)Oxy]Ethyl Ester 和 Trimethylamine
Ethylenedioxy-2-(Methacryloyloxy)Ethoxyphosphine置于十二/十四烷基二甲基氧化胺体系中,用 乙腈 作为反应溶剂,化学反应 48.67H,反应生成 2-甲基丙烯酰氧乙基磷酸胆碱
参考文献:Preparation Of Phospholipid Analogues Using The Phosphoramidite Route
标题:Preparation Of Phospholipid Analogues Using The Phosphoramidite Route
摘要:磷酸胺酯路线已被用于制备具有生物相容性特性的磷脂类类似物,以及用于制备生物相容性聚合物的单体2-(甲基丙烯酰氧基)乙基磷酰胆碱.对已有方法的改进包括,作为热不稳定的四唑的替代品,使用4,5-二氯咪唑作为酸催化剂,以从相应的磷酸胺酯制备磷酸酯,并使用氧化三甲胺作为氧化剂,将磷酸酯转化为相应的磷酸盐.
DOI:10.1039/a910270L

海关参考信息

专利信息


专利号:WO-2024151591-A1
优先权日:2023-01-10
标 题 :Microwave-assisted synthesis of polyacrylic beads and the use thereof
发明人:TEHRANI ROUZBEH AFSARMANESH; ALIMOHAMMADI FARBOD
权利人:UNIV TEMPLE
摘要:A novel method of synthesizing polyacrylic beads, comprising the steps of suspending a monomer and a cross-linking agent in a solution, heating the solution in a microwave reactor, cooling the solution, and collecting the polyacrylic beads. The polyacrylic beads can be used in to remove solutes from various solutions, including blood, porcine blood, dialysate, serum, contaminated water, wastewater, and combinations thereof.

专利号:US-12037430-B2
优先权日:2018-10-17
标 题:Target substance polymer replica substrate, method for producing same, and method for producing substrate sensor
发明人:TAKEUCHI TOSHIFUMI; SUNAYAMA HIROBUMI; TAKANO ERI
权利人:UNIV KOBE NAT UNIV CORP; MURATA MANUFACTURING CO
摘要:The present invention provides a polymer replica of a target molecule, the polymer replica being capable of accurately inheriting surface information possessed by the target molecule in a molecular imprinting technique. A polymer replica of a target substance, the target substance having multiple types of binding groups including at least a binding group BG 1 and a binding group BG 2 on the surface, wherein: the polymer replica is configured from a second molecularly imprinted polymer having, as a template, a first molecularly imprinted polymer having the target substance as a template; the polymer replica has on the surface thereof at least a binding group bg 1 at a position corresponding to the position of binding group BG 1 and a binding group bg 2 at a position corresponding to the position of the binding group BG 2 on the surface of the target substance; and the polymer replica of the target substance can be used as a template during synthesis of a molecularly imprinted polymer having a specific recognition site for the target substance because the polymer replica accurately inherits the surface information possessed by the target molecule.

专利号:US-10968173-B2
优先权日:2016-07-07
标题:Thiocarbonylthio compounds as chain transfer agents suitable for raft polymerization
发明人:COCHRAN ERIC W; HERNANDEZ NACU; FORRESTER MICHAEL; HOHMANN AUSTIN
权利人:UNIV IOWA STATE RES FOUND INC
摘要:The present invention relates to a compound having the structure of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as described herein. The present invention also relates to a process for the preparation of a compound of formula (I) and to a process for the synthesis of a polymer using the compound of formula (I) through controlled free radical polymerization.

专利号:WO-2013017825-A1
优先权日:2011-07-29
标题 :Block copolymer synthesis
发明人:ARMES STEVEN P; SEMSARILAR MONA
权利人:UNIV SHEFFIELD; ARMES STEVEN P; SEMSARILAR MONA
摘要:The present invention relates to a method of preparing, in an alcohol-based medium, colloidally stable polymeric particles comprising an alcohol-insoluble block copolymer of Formula B : Formula B wherein P 1 represents an alcohol-soluble polymeric component derived from a suitable monomer M 1 and P 2 represents a substantially alcohol-insoluble polymeric component derived from an alcohol-soluble monomer M 2 . The block copolymer of Formula B is formed by a radical addition fragmentation chain transfer (RAFT) polymerisation of the alcohol-soluble M 2 monomers in the presence of an alcohol-soluble macromolecular chain transfer agent (macro- CTA) of the formula P 1 -X, where X is a suitable RAFT chain transfer agent. The resulting diblock copolymer particles are formed in situ during the course of the RAFT polymerisation reaction. As such, particles of varying size, morphology and surface charge can be duly prepared with very high monomer conversions for M 2 by varying the reaction conditions.

专利号:US-6270788-B1
优先权日:1998-04-03
标 题:Implantable medical device
发明人:KOULIK EDOUARD; VINCENT LARIK; CAHALAN PATRICK; FOGT ERIC; ISHIHARA KAZUHIKO; NAKABAYASHI NOBUO
权利人:MEDTRONIC INC
摘要:A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using methacrylate or acrylate monomers with a functional group (primary amino group) for subsequent attachment of heparin. Synthesis of the copolymer coating is carried out using the proper proportion of hydrophobic monomer/hydrophilic monomer/functional monomer in order to optimize the solubility of the copolymer in alcohol, its insolubility in water (before and after heparin coupling), the heparin coupling efficacy and heparin bioactivity. Once the copolymer coating is fashioned, a medical article is coated with it. The coating is thereafter dried and heparin attached. In such a manner the present invention provides for a method for making a biocompatible medical article, and preferably, a blood compatible medical article.

专利号:US-9611335-B2
优先权日:2010-03-10
标题 :Polymer synthesis
发明人:ARMES STEVEN P; LI YUTING
权利人:ARMES STEVEN P; LI YUTING; UNIV SHEFFIELD
摘要:A method of preparing a block copolymer of Formula (B) wherein P 1 represents a substantially aqueously soluble polymeric component and P 2 represents a substantially aqueously insoluble polymeric component, comprises admixing an aqueously soluble polymer macro-chain transfer agent comprising P 1 with a monomer (M 2 ) and initiating an aqueous dispersion-type radical addition fragmentation chain transfer (RAFT) polymerization. (P 1 ) is derived from a monomer (M 1 ) selected from monomers of the Formulae (M 1A ), (M 1B ) and/or (M 1C ) where R 1 , R 10 and R 11 represent a substituent of (M 1A ) or (M 1C ) which allows P 1 to be at least partially aqueously soluble, R 2 represents H, CH 3 or CN, R S represents one or more substituents of the aromatic ring effective to allow P 1 to be at least partially aqueously soluble, and monomer M 2 is selected from: where R 3 is a substituent of (M 2 ) which allows P 2 to be substantially aqueously insoluble, and R 4 and R 6 independently represent H or methyl.
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主要参考文献

[参考文献]: Haiyin Li, Et Al. Zwitterionic Red Fluorescent Polymeric Nanoparticles For Cell Imaging. Macromol Biosci. 2014 Oct;14(10):1361-7.
[参考文献]: Megan A Jamiolkowski, Et Al. Real Time Visualization And Characterization Of Platelet Deposition Under Flow Onto Clinically Relevant Opaque Surfaces. J Biomed Mater Res A. 2015 Apr;103(4):1303-11.
[参考文献]: N Nakabayashi, Et Al. Preparation Of Non-Thrombogenic Materials Using 2-Methacryloyloxyethyl Phosphorylcholine. Biomaterials. 2003 Jun;24(13):2431-5.
[参考文献]: Takamasa Uekita, Et Al. Oncogenic Ras/erk Signaling Activates Cdcp1 To Promote Tumor Invasion And Metastasis. Mol Cancer Res. 2014 Oct;12(10):1449-59.
[参考文献]: Thuy V Nguyen, Et Al. Sorafenib Resistance And Jnk Signaling In Carcinoma During Extracellular Matrix Stiffening. Biomaterials. 2014 Jul;35(22):5749-59.

合成参考文献


摘要:Compound: Poly(MPC)
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