Ethylenedioxy-2-(Methacryloyloxy)Ethoxyphosphine置于十二/十四烷基二甲基氧化胺体系中,用 乙腈 作为反应溶剂,化学反应 48.67H,反应生成 2-甲基丙烯酰氧乙基磷酸胆碱 参考文献:Preparation Of Phospholipid Analogues Using The Phosphoramidite Route 标题:Preparation Of Phospholipid Analogues Using The Phosphoramidite Route 摘要:磷酸胺酯路线已被用于制备具有生物相容性特性的磷脂类类似物,以及用于制备生物相容性聚合物的单体2-(甲基丙烯酰氧基)乙基磷酰胆碱.对已有方法的改进包括,作为热不稳定的四唑的替代品,使用4,5-二氯咪唑作为酸催化剂,以从相应的磷酸胺酯制备磷酸酯,并使用氧化三甲胺作为氧化剂,将磷酸酯转化为相应的磷酸盐. DOI:10.1039/a910270L
专利号:WO-2024151591-A1 优先权日:2023-01-10 标 题 :Microwave-assisted synthesis of polyacrylic beads and the use thereof 发明人:TEHRANI ROUZBEH AFSARMANESH; ALIMOHAMMADI FARBOD 权利人:UNIV TEMPLE 摘要:A novel method of synthesizing polyacrylic beads, comprising the steps of suspending a monomer and a cross-linking agent in a solution, heating the solution in a microwave reactor, cooling the solution, and collecting the polyacrylic beads. The polyacrylic beads can be used in to remove solutes from various solutions, including blood, porcine blood, dialysate, serum, contaminated water, wastewater, and combinations thereof.
专利号:US-12037430-B2 优先权日:2018-10-17 标 题:Target substance polymer replica substrate, method for producing same, and method for producing substrate sensor 发明人:TAKEUCHI TOSHIFUMI; SUNAYAMA HIROBUMI; TAKANO ERI 权利人:UNIV KOBE NAT UNIV CORP; MURATA MANUFACTURING CO 摘要:The present invention provides a polymer replica of a target molecule, the polymer replica being capable of accurately inheriting surface information possessed by the target molecule in a molecular imprinting technique. A polymer replica of a target substance, the target substance having multiple types of binding groups including at least a binding group BG 1 and a binding group BG 2 on the surface, wherein: the polymer replica is configured from a second molecularly imprinted polymer having, as a template, a first molecularly imprinted polymer having the target substance as a template; the polymer replica has on the surface thereof at least a binding group bg 1 at a position corresponding to the position of binding group BG 1 and a binding group bg 2 at a position corresponding to the position of the binding group BG 2 on the surface of the target substance; and the polymer replica of the target substance can be used as a template during synthesis of a molecularly imprinted polymer having a specific recognition site for the target substance because the polymer replica accurately inherits the surface information possessed by the target molecule.
专利号:US-10968173-B2 优先权日:2016-07-07 标题:Thiocarbonylthio compounds as chain transfer agents suitable for raft polymerization 发明人:COCHRAN ERIC W; HERNANDEZ NACU; FORRESTER MICHAEL; HOHMANN AUSTIN 权利人:UNIV IOWA STATE RES FOUND INC 摘要:The present invention relates to a compound having the structure of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as described herein. The present invention also relates to a process for the preparation of a compound of formula (I) and to a process for the synthesis of a polymer using the compound of formula (I) through controlled free radical polymerization.
专利号:WO-2013017825-A1 优先权日:2011-07-29 标题 :Block copolymer synthesis 发明人:ARMES STEVEN P; SEMSARILAR MONA 权利人:UNIV SHEFFIELD; ARMES STEVEN P; SEMSARILAR MONA 摘要:The present invention relates to a method of preparing, in an alcohol-based medium, colloidally stable polymeric particles comprising an alcohol-insoluble block copolymer of Formula B : Formula B wherein P 1 represents an alcohol-soluble polymeric component derived from a suitable monomer M 1 and P 2 represents a substantially alcohol-insoluble polymeric component derived from an alcohol-soluble monomer M 2 . The block copolymer of Formula B is formed by a radical addition fragmentation chain transfer (RAFT) polymerisation of the alcohol-soluble M 2 monomers in the presence of an alcohol-soluble macromolecular chain transfer agent (macro- CTA) of the formula P 1 -X, where X is a suitable RAFT chain transfer agent. The resulting diblock copolymer particles are formed in situ during the course of the RAFT polymerisation reaction. As such, particles of varying size, morphology and surface charge can be duly prepared with very high monomer conversions for M 2 by varying the reaction conditions.
专利号:US-6270788-B1 优先权日:1998-04-03 标 题:Implantable medical device 发明人:KOULIK EDOUARD; VINCENT LARIK; CAHALAN PATRICK; FOGT ERIC; ISHIHARA KAZUHIKO; NAKABAYASHI NOBUO 权利人:MEDTRONIC INC 摘要:A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using methacrylate or acrylate monomers with a functional group (primary amino group) for subsequent attachment of heparin. Synthesis of the copolymer coating is carried out using the proper proportion of hydrophobic monomer/hydrophilic monomer/functional monomer in order to optimize the solubility of the copolymer in alcohol, its insolubility in water (before and after heparin coupling), the heparin coupling efficacy and heparin bioactivity. Once the copolymer coating is fashioned, a medical article is coated with it. The coating is thereafter dried and heparin attached. In such a manner the present invention provides for a method for making a biocompatible medical article, and preferably, a blood compatible medical article.
专利号:US-9611335-B2 优先权日:2010-03-10 标题 :Polymer synthesis 发明人:ARMES STEVEN P; LI YUTING 权利人:ARMES STEVEN P; LI YUTING; UNIV SHEFFIELD 摘要:A method of preparing a block copolymer of Formula (B) wherein P 1 represents a substantially aqueously soluble polymeric component and P 2 represents a substantially aqueously insoluble polymeric component, comprises admixing an aqueously soluble polymer macro-chain transfer agent comprising P 1 with a monomer (M 2 ) and initiating an aqueous dispersion-type radical addition fragmentation chain transfer (RAFT) polymerization. (P 1 ) is derived from a monomer (M 1 ) selected from monomers of the Formulae (M 1A ), (M 1B ) and/or (M 1C ) where R 1 , R 10 and R 11 represent a substituent of (M 1A ) or (M 1C ) which allows P 1 to be at least partially aqueously soluble, R 2 represents H, CH 3 or CN, R S represents one or more substituents of the aromatic ring effective to allow P 1 to be at least partially aqueously soluble, and monomer M 2 is selected from: where R 3 is a substituent of (M 2 ) which allows P 2 to be substantially aqueously insoluble, and R 4 and R 6 independently represent H or methyl.
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