CAS: 138113-08-3; 7-Methoxy-1-Naphthylacetonitrile

相似化合物

6836-22-2 138113-08-3 138113-07-2

上下游产品

CAS号138113-07-2 7-甲氧基萘-1-乙酰胺 | CAS号861960-34-1 7-甲氧基-3,4-二氢-1-萘基乙腈 | CAS号1079774-32-5 (7-hydroxy-1-na... | CAS号77-78-1 硫酸二甲酯 | CAS号360766-78-5 1-hydroxy-7-met... | CAS号6836-19-7 7-甲氧基-1-萘满酮 | CAS号6836-22-2 7-甲氧基-1-萘乙酸 | CAS号773837-37-9 sodium cyanide | CAS号6836-22-2 7-甲氧基-1-萘乙酸 | CAS号138112-76-2 阿戈美拉汀 | CAS号138113-09-4 7-甲氧基-1-萘乙胺 | CAS号139525-77-2 2-(7-甲氧基萘-1-基)乙胺盐酸盐 | CAS号138112-82-0 N-(2-(7-Methoxy... | CAS号138112-91-1 3,5-dichloro-N-... | CAS号138113-03-8 N-cyclopropylca... | CAS号138112-78-4 N-[2-(7-methoxy... | CAS号138113-02-7 N-[2-(7-methoxy...

7-甲氧基-1-萘满酮置于正丁基锂,对甲苯磺酸,2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 四氢呋喃,正己烷,二氯甲烷,苯 用作溶剂,化学反应 2.0H,反应生成2-(7-甲氧基萘-1-基)乙腈
参考文献:萘系褪黑素受体配体的合成
标题:萘系褪黑素受体配体的合成
摘要:描述了一种高效且通用的合成方法,用于合成褪黑激素,化合物 7 及其 2-烷基取代类似物 8 的萘类似物.该方法的特点是通过将 Lich2Cn 亲核加成到取代的 1-四氢萘酮,然后通过 2 步反应序列进行芳构化,用 Ddq 脱氢和 Tsoh 催化脱水来合成取代的 1-萘基乙腈 12 和 19.
Doi:10.1081/scc-100000591

专利信息

专利号:US-7479569-B2
优先权日:2004-02-13
标题:Process for the synthesis of (7-methoxy-3,4-dihydro-1-naphthalenyl) acetonitrile and its application in the synthesis of agomelatine
发明人：SOUVIE JEAN-CLAUDE; GONZALEZ BLANCO ISAAC
权利人:SERVIER LAB
摘要:A process for the industrial synthesis of the compound of formula (I) n nApplication in the synthesis of agomelatine.

专利号:US-8436206-B2
优先权日:2007-08-03
标 题:Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and application in the synthesis of agomelatine
发明人：DUBUFFET THIERRY; LECOUVE JEAN-PIERRE; HERMET JEAN-PAUL
权利人:DUBUFFET THIERRY; LECOUVE JEAN-PIERRE; HERMET JEAN-PAUL; SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I) n nApplication of such process in the synthesis of agomelatine.

专利号:US-7994359-B2
优先权日:2004-02-13
标题:Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine
发明人：SOUVIE JEAN-CLAUDE; BLANCO ISAAC GONZALEZ
权利人:SERVIER LAB
摘要:A process for the industrial synthesis of the compound of formula (I) n nApplication in the synthesis of agomelatine.

专利号:US-7999129-B2
优先权日:2004-02-13
标 题:Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine
发明人：SOUVIE JEAN-CLAUDE; BLANCO ISAAC GONZALEZ
权利人:SERVIER LAB
摘要:A process for the industrial synthesis of the compound of formula (I) n nApplication in the synthesis of agomelatine.

专利号:US-9604911-B2
优先权日:2013-12-05
标题 :Process for the synthesis of agomelatine
发明人：BRIERE JEAN-FRANÇOIS; LEBEUF RAPHAËL; LEVACHER VINCENT; HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I):

专利号:US-RE46218-E
优先权日:2011-01-05
标 题 :Process for the synthesis of agomelatine
发明人：ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI
权利人:SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I)