CAS: 156-81-0; Pyrimidine-2,4-Diamine

相似化合物

1004-38-2 2434-56-2 2725790-86-1

上下游产品

CAS号1004-01-9 5-溴嘧啶-2,4-二胺 | CAS号73183-34-3 双戊酰二硼 | CAS号58243-08-6 反式-3-乙氧基丙烯腈 | CAS号50-01-1 盐酸胍 | CAS号3993-78-0 2-氨基-4-氯嘧啶 | CAS号2032-34-0 氰基乙醛缩二乙醇 | CAS号3934-20-1 2,4-二氯嘧啶 | CAS号156-83-2 2,4-二氨基-6-氯嘧啶 | CAS号14001-63-9 4-甲基-2-甲硫基嘧啶 | CAS号15640-40-1 Phenol,4,4'-met... | CAS号74638-76-9 2,4-二氨基嘧啶-3-氧化物 | CAS号462651-80-5 7-氨基咪唑并[1,2-A]嘧啶 | CAS号591227-12-2 2-phenylimidazo...

2,4-二氨基-6-氯嘧啶置于溶剂黄146,锌体系中,化学反应生成2,4-二氨基嘧啶
参考文献:Buettner,Chemische Berichte,1903,Vol. 36,P. 2234
标题:Buettner,Chemische Berichte,1903,Vol. 36,P. 2234

专利信息

专利号:WO-2025101716-A1
优先权日:2023-11-07
标题:Processes for synthesis of trifunctionalized sulfur(vi) compounds
发明人：LOPCHUK JUSTIN; SHULTZ ZACHARY; ATHAWALE PARESH
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure describes processes for the asymmetric synthesis of trifunctionalized sulfur(VI) containing organic compounds of Formula I and Formula VI, as well as compounds of Formula I and Formula VI prepared by the processes described.

专利号:US-2023220434-A1
优先权日:2020-01-09
标 题 :Composistions and methods for crispr enabled dna synthesis
发明人：LYNCH MICHAEL DAVID; MOREB EIRIK ADIM; YANG TIAN
权利人:UNIV DUKE
摘要:Methods for CRISPR Enabled DNA Synthesis and compositions arising from the methods are provided. The methods may include ligation of partially single stranded DNA donor and acceptor oligonucleotides that are covalently linked to a subsequence of the target DNA to be sequenced followed by cleavage of the ligated product. In this manner the donor and acceptor oligonucleotides shuttle a growing subsequence of the target DNA with each cycle. A mutant Cpfl nuclease is missing non-specific ssDNA nuclease activity may be used for cleavage of the ligation product. Fourteen ligation/cleavage cycles can result in synthesis of ssDNA of greater than 10,000 bp in length.

专利号:US-8825411-B2
优先权日:2004-05-04
标 题:Design, synthesis and assembly of synthetic nucleic acids
发明人：GOVINDARAJAN SRIDHAR; MINSHULL JEREMY S; NESS JON E
权利人:GOVINDARAJAN SRIDHAR; MINSHULL JEREMY S; NESS JON E; DNA TWOPOINTO INC
摘要:Methods of synthesizing oligonucleotides with high coupling efficiency (>99.5%) are provided. Methods for purification of synthetic oligonucleotides are also provided. Instrumentation configurations for oligonucleotide synthesis are also provided. Methods of designing and synthesizing polynucleotides are also provided. Polynucleotide design is optimized for subsequent assembly from shorter oligonucleotides. Modifications of phosphoramidite chemistry to improve the subsequent assembly of polynucleotides are provided. The design process also incorporates codon biases into polynucleotides that favor expression in defined hosts. Design and assembly methods are also provided for the efficient synthesis of sets of polynucleotide variants. Software to automate the design and assembly process is also provided.

专利号:US-7105666-B2
优先权日:2002-06-27
标 题:Synthesis of purine derivatives
发明人：HAMMARSTROEM LARS G J; KRAUSS NANCY ELISABTH; LABADIE SHARADA SHENVI; SMITH DAVID BERNARD; TALAMAS FRANCISCO XAVIER
权利人:ROCHE PALO ALTO LLC
摘要:The present invention provides a method for producing 2-, 6-, 8- and 9-substituted purine compounds from 4,6-dihalo-5-nitro-2-alkyl-pyrimidine compounds in solution or by solid phase techniques. The present process provides for the sequential introduction of amine substituents at the 4- and 6-positions, displacement of an alkylsulfony group at the 2-position of the pyrimidine, reduction of the nitro group and formation of the imidazole portion of the purine compound. Furthermore, the methods of the present invention are ideally suited to the preparation of a library of purine compounds.

专利号:US-7256197-B2
优先权日:2001-10-12
标 题 :Methods for synthesis of diarylmethanes
发明人：ROSOWSKY ANDRE; CHEN HAN
权利人:DANA FARBER CANCER INST INC
摘要:The present invention relates to dihydrofolate reductase inhibitors having an aromatic group and a heteroaromatic group linked by a methylene group; methods of preparation of dihydrofolate reductase inhibitors that include metal mediated cross coupling of an aromatic halide or heteroaromatic halide with an organozinc reagent; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such dihydrofolate reductase inhibitors.

专利号:US-6232462-B1
优先权日:1994-08-30
标题:Reduction of nonspecific hybridization by using novel base-pairing schemes
发明人：COLLINS MARK L; HORN THOMAS; SHERIDAN PATRICK J; WARNER BRIAN D; URDEA MICHAEL S
权利人:BAYER AG
摘要:Methods are provided for substantially reducing background signals encountered in nucleic acid hybridization assays. The method is premised on the elimination or significant reduction of the phenomenon of nonspecific hybridization, so as to provide a detectable signal which is produced only in the presence the target polynucleotide of interest. In addition, a novel method for the chemical synthesis of isoguanosine or 2′-deoxy-isoguanosine is provided. The invention also has applications in antisense and aptamer therapeutics and drug discovery.