CAS: 17630-76-1; 5-Chloroindoline-2,3-Dione

上下游产品

CAS号302-17-0 水合氯醛 | CAS号106-47-8 对氯苯胺 | CAS号65798-06-3 N-(4-chlorophen... | CAS号91-56-5 靛红 | CAS号17422-32-1 5-氯吲哚 | CAS号79-37-8 草酰氯 | CAS号85124-16-9 5-chloro-1H-ind... | CAS号113423-48-6 3,3-二溴-5-氯-1,3-... | CAS号873-38-1 2-溴-4-氯苯胺 | CAS号17630-75-0 5-氯氧化吲哚 | CAS号35166-78-0 (环己基甲基)溴化镁 | CAS号4743-17-3 5-氯靛红酸酐 | CAS号33289-51-9 6-氯-2-噻吩-2-基喹啉-4-羧酸 | CAS号199179-57-2 6-氯-2-氧代-1,2-二氢... | CAS号202288-38-8 2-(5-chloro-2-o... | CAS号118-75-2 四氯对醌 | CAS号874-17-9 2,6-二溴-4-氯苯胺 | CAS号932-31-0 邻甲苯基溴化镁 | CAS号6633-62-1 6-氯-2-苯基喹啉-4-甲酸 | CAS号635-21-2 2-氨基-5-氯苯甲酸

5-氯吲哚-3-甲醛置于sodium Chloride体系中,用 水,乙腈 用作溶剂,化学反应 2.0H,以81%的收率获得5-氯靛红
参考文献:氯化钠/ Oxone高效合成通用的合成子3-氯代吲哚
标题:氯化钠/ Oxone高效合成通用的合成子3-氯代吲哚
摘要:本工作描述了使用简单的可持续合成方法将吲哚-3-甲醛直接转化为3-氯氧吲哚的简便方法.从环境的角度出发,开发了一种在ch 3 Cn:H 2 O(1:1)系统中的nacl /恶烷组合物,用于多种吲哚衍生物的直接氧化氯化.这种氯化策略更可行,更便宜,并且易于获得潜在的3-氯代吲哚.另外,这种环境友好的方法也可适用于以高收率构建伊斯汀衍生物.
Doi:10.1039/c8Nj04855J

专利信息

专利号:WO-2016147205-A1
优先权日:2015-03-13
标题 :Novel substituted 3-spirophosphoryl pyrazole-2-oxindoles as anti-infectives and process for the synthesis thereof
发明人：SURYAVANSHI GURUNATH MALLAPPA; SHELKE ANIL MARUTI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to novel substituted 3-spirophosphoryl, pyrazole-2-oxindoles of Formula (I) and its pharmaceutically acceptable salts, esters, ethers, isomers, stereoisomers, positional isomers and pplymorphs. The present invention further relates to one pot, one step process for the synthesis of spirophosphoiyl pyrazole oxindoles of Formula (I) with yield in the range of 70-85%.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:US-8497296-B2
优先权日:2011-03-31
标 题:N,N′-hydrazino-bis-isatin derivatives with selective activity against multidrug-resistant cancer cells
发明人：HASSAN TAREK ABOUL-FADL MOHAMED; KADI ADNAN AHMED; ABDEL-AZIZ HATEM ABDEL-KHADER
权利人:HASSAN TAREK ABOUL-FADL MOHAMED; KADI ADNAN AHMED; ABDEL-AZIZ HATEM ABDEL-KHADER; UNIV KING SAUD
摘要:The invention is directed to a compound of Formula (I), n nwherein R is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; R 1 is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; X is selected from the group consisting of hydrogen atom or halogen atom; and Y is selected from the group consisting of hydrogen atom, halogen atom, C 1 -C 4 alkyl group, nitro group, and —OCF 3 group, as well as for its use in therapy, preferably for the treatment of cancer, and to a related pharmaceutical composition, the use of the compound for the manufacture of a medicament for the respective medical indication, and a method of synthesis of the compounds of the invention.

专利号:US-8933248-B2
优先权日:2012-06-21
标 题:3-substituted-3-hydroxy oxindole derivatives and process for preparation thereof
发明人：RAO MANDAPATI MOHAN; PRATHIMA PARVATHANENI SAI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to expedient method for synthesis of 3-substituted-3-hydroxy-oxindole derivatives, which are useful as synthetic precursors to valuable pharmaceutical compounds. These are synthesized by reacting nitromethane with the corresponding isatins of formula (I). The reaction process of isatins was carried using water as a solvent at room temperature to form the corresponding 3-hydroxy-3-nitromethylindolin-2-ones of formula (II).

专利号:US-7149280-B2
优先权日:2002-12-23
标 题 :Synthesis and screening of ligands using X-ray crystallography
发明人：JHOTI HARREN; CONGREVE MILES STUART; O'REILLY MARC; WYATT PAUL GRAHAM
权利人:ASTEX THERAPEUTICS LTD
摘要:A method for identifying a ligand of a target macromolecule is disclosed, comprising the steps of: soaking one or more crystals of the target macromolecule in a solution containing a collection of compounds generated in situ or separate from the crystal, where the solution has been prepared without the purification of the synthesized collection of compounds; obtaining an X-ray crystal diffraction pattern of the soaked macromolecule crystal; and using said X-ray crystal diffraction pattern to identify any compound bound to the macromolecule crystal, said compound being a ligand of the target macromolecule.

专利号:US-8987195-B2
优先权日:2012-08-08
标 题:HCV NS3 protease inhibitors
发明人：BARA THOMAS; BHAT SATHESH; BISWAS DIPSHIKHA; BROCKUNIER LINDA; BURNETT DUANE A; CHACKALAMANNIL SAMUEL; CHELLIAH MARIAPPAN V; CHEN AUSTIN; CLASBY MARTIN; COLANDREA VINCE J; GUO ZHUYAN; HAN YONGXIN; JAYNE CHARLES; JOSIEN HUBERT; MARCANTONIO KAREN; MIAO SHOUWU; NEELAMKAVIL SANTHOSH; PINTO PATRICK; RAJAGOPALAN MURALI; SHAH UNMESH; VELAZQUEZ FRANCISCO; VENKATRAMAN SRIKANTH; XIA YAN
权利人:MERCK SHARP & DOHME; MERCK CANADA INC
摘要:The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds.