CAS: 20808-12-2; ((Fluoromethyl)Sulfonyl)Benzene

上下游产品

CAS号60839-94-3 Fluoromethylphe... | CAS号100-68-5 茴香硫醚 | CAS号331463-16-2 ((dichlorofluor... | CAS号1042681-81-1 (3E)-1-fluoro-2... | CAS号104-87-0 对甲基苯甲醛 | CAS号100-52-7 苯甲醛 | CAS号882-33-7 二苯二硫醚 | CAS号130755-47-4 dichlorofluorom... | CAS号116109-54-7 [chloro(fluoro)... | CAS号114969-27-6 [cyclohexyliden... | CAS号34063-53-1 para-nitrobenzy... | CAS号69709-34-8 1-(benzenesulfo... | CAS号910650-82-7 氟双(苯磺酰基)甲烷

茴香硫醚置于selectfluor,三乙胺,间氯过氧苯甲酸体系中,用 乙腈,二氯甲烷 用作溶剂,化学反应 0.84H,以21%的收率获得氟甲基苯基砜
参考文献:通过氢键实现活化的烷基氟化物的亲核取代反应
标题:通过氢键实现活化的烷基氟化物的亲核取代反应
摘要:已经发现水作为助溶剂的存在使得活化的烷基氟化物能够进行双分子亲核取代反应.Dft计算表明,活化是通过更强的f...h 2 O相互作用稳定过渡结构并减少c-F键伸长而进行的,而不是简单的过渡态静电稳定.总体而言,研究结果提出了通过h键激活cf键的独特策略.
Doi:10.1021/ol400765A

专利信息

专利号:US-7119232-B2
优先权日:2004-03-26
标题 :Nucleophilic substitution reactions of difluorormethyl phenyl sulfone with alkyl halides leading to the facile synthesis of terminal 1,1-difluoro-1-alkenes and difluoromethylalkanes
发明人：PRAKASH G K SURYA; HU JINBO; OLAH GEORGE A; WANG YING
权利人:UNIV SOUTHERN CALIFORNIA
摘要:(Benzenesulfonyl)difluoromethyl anion, in situ generated from difluoromethyl phenyl sulfone and a base, was found to easily undergo nucleophilic substitution reactions (S N 2) with primary alkyl halides, elemental halogens, and perfluoroalkyl halides with good selectivity. The formed (benzenesufonyl)difluoromethylalkanes are useful intermediates for the facile preparation of 1,1-difluoro-1-alkenes and difluoromethylalkanes. Thus, difluoromethyl phenyl sulfone acts as both “CF 2 â•?â€? and “CF 2 H − â€? synthons

专利号:US-12129274-B2
优先权日:2018-04-03
标题:Modular synthesis of aminoglycosides
发明人：CALABRESE ANDREW ANTONY; KANE TIMOTHY ROBERT; HILDEBRANDT DARIN; LOPEZ MICHAEL; EVDOKIMOV NIKOLAI; COHEN FREDERICK; BAYRAKDARIAN MALKEN; XU SANIJIA; DESJARDINS SAMUEL; SOUEIDAN OLIVIER
权利人:REVAGENIX INC
摘要:The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds and the compounds used in such preparations.

专利号:US-2022411456-A1
优先权日:2018-04-03
标题 :Modular synthesis of aminoglycosides

专利号:US-11673907-B2
优先权日:2018-04-03
标 题:Modular synthesis of aminoglycosides

专利号:US-2006052643-A1
优先权日:2004-03-26
标题:Nucleophilic substitution reactions of difluorormethyl phenyl sulfone with alkyl halides leading to the facile synthesis of terminal 1,1-difluoro-1-alkenes and difluoromethylalkanes

专利号:US-9029563-B2
优先权日:2012-01-06
标题:Substituted 1-benzylindolin-2-one analogs as positive allosteric modulators of muscarinic acetylcholine M1 receptors
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; MELANCON BRUCE J; POSLUSNEY MICHAEL S
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 1-benzylindolin-2-one analog compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.