专利号:US-7078524-B2 优先权日:2002-11-22 标题:Process for the synthesis of ganciclovir 发明人:BABU JAYACHANDRA SURESH; RAY PURNA CHANDRA; KUMAR YATENDRA; KHANDURI CHANDRA HAS 权利人:RANBAXY LAB LTD 摘要:The present invention relates to an industrial useful process for the synthesis of antiviral compound, ganciclovir which comprises dissolving a mixture containing N-7 and N-9 isomers of structural formulae, II and III, respectively: n n nin a solvent or a mixture of solvents; separating the N-7 and N-9 isomers; and hydrolizing the N-9 isomer to obtain ganciclovir.
专利号:US-6043364-A 优先权日:1996-02-22 标 题:Regiospecific process for synthesis of acyclic nucleosides 发明人:KUMAR ASHOKE; SINGH DHARMENDRA; WANI MUKESH JAGANNATH; JOSHI NARENDRA SRIRAM; THOMBRE PRAVIN SAHADEV; RAWAT AJAY SINGH 权利人:LUPIN LAB LTD 摘要:N-7 isomer of the formula is converted into a N-9 isomer of the formula by heating a suspension of the N-7 isomer in an alkylating agent of the formula
专利号:EP-0590361-A1 优先权日:1992-09-17 标 题 :Process for the preparation of 2-amino-6-halopurines 发明人:HAGEN HELMUT DR; RAATZ PETER DR 权利人:BASF AG 摘要:Preparation of 2-amino-6-halopurines I (X = halogen) by hydrolysis of 2-acylamino-6-halopurines II (R¹, R² = acyl; R² = H) in the presence of an acid or base and preparation of II by acylation of guanine III to acylguanine Va or Vb and halogenation of V with a halogenating agent VI to II.n n n V and II are new intermediates for the synthesis of I when R1 and R2 are haloacetyl.
专利号:US-2004102628-A1 优先权日:2002-11-22 标 题:Process for the synthesis of ganciclovir
专利号:EP-0976751-A1 优先权日:1996-04-09 标题 :A process for the isomerisation of an N-7 isomer into an N-9 isomer useful in the synthesis of acyclic nucleosides
专利号:IT-MI941149-A1 优先权日:1994-06-02 标题 :PROCESS FOR THE SYNTHESIS OF 2-AMINO-6-CHLOROPURINE