CAS: 3512-75-2; 4-Chloro-2,6-Dimethylpyridine

相似化合物

3678-63-5 104711-65-1 98420-91-8

上下游产品

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2,6-二甲基-4-硝基吡啶 1-氧化物置于盐酸,三氯化磷体系中,用 氯仿 作为反应溶剂,化学反应生成 4-氯-2,6-二甲基吡啶
参考文献:Novel Nevirapine-Like Inhibitors With Improved Activity Against Nnrti-Resistant Hiv: 8-Heteroarylthiomethyldipyridodiazepinone Derivatives
标题:Novel Nevirapine-Like Inhibitors With Improved Activity Against Nnrti-Resistant Hiv: 8-Heteroarylthiomethyldipyridodiazepinone Derivatives
摘要:A Series Of 8-Heteroarylthiomethyidipyridodiazepinone Derivatives Were Prepared And Evaluated For Their Antiviral Profile Against Wild Type Virus And The Important K103N/y181C Mutant As An Indicator For Broad Activity. 2,6-Dimethylpyridine Derivative 16 Was Found To Have A Good Pharmacokinetic Profile In Spite Of Poor Metabolic Stability In Rat Liver Microsomes. (C) 2003 Published By Elsevier Ltd.
DOI:10.1016/j.Bmcl.2003.11.049

专利信息

专利号:US-6437139-B1
优先权日:1997-05-06
标题 :Synthesis of pharmaceutically useful pyridine derivatives
发明人：ZOGHBI MICHEL; CHEN LIQUIN
权利人:PDI RES LAB INC
摘要:A process is provided for the preparation of compounds of formula I,useful in the preparation of compounds such as Omeprazole, Lansoprazole and Pantoprazole, wherein R1=H or CH3, R2=H or CH3, R3=Alkoxy (1-4C), OCH2CF3, Cyano, Hydrogen, Halogen, Acetoxy or Aryloxy, any electron withdrawing group or salts (organic or inorganic) of electron donating groups, R=Alkoxy, Hydroxy, Halogen, Activated ester, Tosylate, Mesylate, Thiol or Xanthyl, wherein the process for the preparation of compound of formula I employs a free radical reaction to functionalize the 2-position.

专利号:CN-102259015-A
优先权日:2010-05-27
标 题 :Catalyst for catalytic synthesis of 2,6-lutidine and synthesis method thereof

专利号:WO-9933807-A2
优先权日:1997-12-24
标 题 :Synthesis of pharmaceutically useful pyridine derivatives (intermediates) employing free radical substitution reactions to functionalize the 2-position of the pyridine

专利号:CA-2225863-A1
优先权日:1997-05-06
标 题 :Synthesis of pharmaceutical useful pyridine derivatives

专利号:RU-2194701-C2
优先权日:1995-12-18
标 题 :Derivatives of quinazoline, methods of their synthesis, pharmaceutical composition comprising thereof and method of achievement of anti-angiogenic effect and/or effect of decrease of vascular penetration with their using