CAS: 354-38-1; 2,2,2-Trifluoroacetamide

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CAS号383-63-1 三氟乙酸乙酯 | CAS号79-37-8 草酰氯 | CAS号76-05-1 三氟乙酸(TFA) | CAS号89567-94-2 Acetamide, N-[(... | CAS号14618-49-6 N,N-二烯丙基-2,2,2-三氟乙酰胺 | CAS号84353-59-3 1-(2,2,2-triflu... | CAS号84353-55-9 1-(2,2,2-triflu... | CAS号111-40-0 二乙烯三胺 | CAS号359-45-5 N-bromo-2,2,2-t... | CAS号233257-02-8 [(trifluoroacet... | CAS号332-34-3 2,2,2-三氟-4’-甲氧基乙酰苯胺 | CAS号538-43-2 3-苯氧基-1,2-丙二醇 | CAS号50667-69-1 N-(羟甲基)三氟乙酰胺 | CAS号340-07-8 1-三氟乙酰基哌啶 | CAS号2317-69-3 Di-trifluoracet... | CAS号147972-26-7 2-三氟甲基噻吩并[3,2-D... | CAS号407-24-9 双三氟乙酰胺 | CAS号67497-87-4 3-amino-1,1,1-t... | CAS号404-24-0 三氟乙酰苯胺

三氟乙酸乙酯置于氨体系中,用 乙醚 用作溶剂,化学反应生成2,2,2-三氟乙酰胺
参考文献:Microwave Spectra,Hyperfine Splittings And Average Structures Of 3,3,3-Trifluoropropyne,Cf3Cch And Trifluoroacetonitrile,Cf3Cn
标题:Microwave Spectra,Hyperfine Splittings And Average Structures Of 3,3,3-Trifluoropropyne,Cf3Cch And Trifluoroacetonitrile,Cf3Cn
摘要:利用脉冲喷嘴傅立叶变换光谱仪对八种 Cf3Cch 同位素和六种 Cf3Cn 同位素的 J= 1 ↠0 和 J= 2 ↠1 微波跃迁进行了高分辨率研究.通过高精度同位素测量,包括以前未观测到的 13Cf3Cch 物种,可以完整计算出 Cf3Cch 的零点平均结构:R(Cc)= 1.201 (1)å; R(C-C)= 1.474 (5)å; R(C-H)= 1.051 (2)å; ∠ Fcf = 108.3 (2)°; R(C-F)= 1.337 (2)å.对 Cf3Ccd 的氘四极超频结构进行了解析,并在 J= 1 ↠0 转变处进行了测量,得出 Eqq(D)= 201.9 (5.2) Khz.经过必要的振动修正后,我们还根据高分辨率同位素数据计算出了 Cf3Cn 的零点平均结构:R(Cn)= 1.154 (1)埃;R(C-C)= 1.492 (5)埃;∠fcf = 109.2 (2)°;R(C-F)= 1.328 (2)埃.在 J= 1 ↠0 转变处的测量结果给出了 Cf3Cn 中氮四极耦合常数 Eqq(14N)=-4.666 (4) Mhz 的改进值.
Doi:10.1039/ft9938902937

专利信息

专利号:US-6683189-B1
优先权日:1996-02-26
标 题 :Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
发明人：DERVAN PETER B; BAIRD ELDON
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.

专利号:US-5827794-A
优先权日:1994-02-22
标 题 :Supported highly-polar liquid phase chiral sulfonated binap catalyst for asymmetric synthesis of optically active compounds
发明人：DAVIS MARK E; WAN KAM TO
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention relates to water soluble chiral sulfonated 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl and its use as organometallic catalysts for asymmetric synthesis of optically active compounds. Asymmetric reactions of the present invention include those reactions in which organometallic catalysts are commonly used. Such reactions include, but are not limited to, reduction and isomerization reactions on unsaturated substrates and carbon--carbon bond forming reactions. Examples of such reactions include, but are not limited to, hydrogenation, hydroboration, hydrosilylation, hydride reduction, hydroformylation, alkylation, allylic alkylation, arylation, alkenylation, epoxidation, hydrocyanation, disilylation, cyclization and isomerization reactions. n The catalysts of the present invention provide the advantage of functioning in the presence of water without loss in enantioselectivity relative to the nonsulfonated BINAP catalyst in an organic solvent. As a result, the catalysts of the present invention may be employed in water, water miscible solvents, in aqueous--organic two phase solvent systems and in supported aqueous phase catalysts in organic solvents without loss in enantioselectivity. Further, the catalysts of the present invention may also be effectively employed in highly polar solvents such as primary alcohols and ethylene glycol. n The present invention also relates to a method for conducting asymmetric reactions on prochiral unsaturated bonds contained within a compound using the water soluble chiral sulfonated 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl organometallic catalysts of the present invention.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-2006264608-A1
优先权日:2001-08-03
标题 :Bi-directional synthesis of oligoguanidine transport agents
发明人：WENDER PAUL A; VANDEUSEN CHRISTOPHER L; PATTABIRAMAN KANAKA; PELKEY ERIN T; JESSOP THEODORE C
权利人:WENDER PAUL A; VANDEUSEN CHRISTOPHER L; PATTABIRAMAN KANAKA; PELKEY ERIN T; JESSOP THEODORE C
摘要:Synthesis routes that can be adapted to large scale synthesis of oligoguanidine compounds such as oligoarginine compounds are described which use a perguanidinylation step to convert a group of ω-amino groups to the corresponding guanidinyl groups. These compounds find utility as transport agents. Modified oligoguanidine compounds are also described.

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-7910623-B2
优先权日:2005-07-22
标 题 :Synthesis of scabronines and analogues thereof
发明人：DANISHEFSKY SAMUEL J; WATERS STEPHEN P
权利人:SLOAN KETTERING INST CANCER
摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.