CAS: 436799-33-6; 3-Bromo-5-(Trifluoromethyl)Pyridine

该化合物是一种环环状有机化合物,其特点是三点方位有一个环状环以溴原子替代,五点有三氟甲基组别.这种化合物一般无色可粉黄,视其在室温时的物理状态而定,对黄色液体或固体无色性具有不同特性.三氟甲基组别有助于其独特的电子特性,加强其再活性,使其成为有机合成中有价值的中间体,特别是在制药和农用化学产品方面.溴替代成分可参与各种化学反应,包括核细胞替代和交叉反应.此外,由于电阴性氟原子,该化合物的极性可以影响其在不同溶液中的溶解性.安全考虑因素应予以考虑,因为卤化化合物可对环境和健康造成危害.

英文名称3-Bromo-5-(Trifluoromethyl)Pyridine
中文名称3-溴-5-(三氟甲基)吡啶
IUPAC名称3-bromo-5-(trifluoromethyl)pyridine
其它别名3-溴-5-三氟甲基吡啶; 5三氟甲基3溴吡啶
CAS编号436799-33-6
MFCD编号:MFCD04972700
EINECS号:626-819-9
分子式:C6H3BrF3N
分子量:225.99
产品CID: 1446740
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: HEDHNDVPKRVQPN-UHFFFAOYSA-N
InChI=1S/C6H3BrF3N/c7-5-1-4(2-11-3-5)6(8,9)10/h1-3H…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数0.0

相似化合物

114468-04-1 1108724-32-8 1031929-01-7

MSDS等安全信息

GHS象形图
GHS符号GHS06;
注释: Skull and crossbones
危险类别急性毒性类别2(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别3(经口)
急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
严重眼刺激类别2A
警示词Danger(危险)
危险描述H300 |吞咽致命.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H301 |吞咽会中毒.
H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
危险等级6.1
UN编号2811.0
危险品标志T,Xi
包装等级Ⅲ
安全声明26-36/37/39-45
危险类别码25-36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

3,5-二溴吡啶置于potassium Fluoride,Copper(L) Iodide,异丙基氯化镁体系中,用四氢呋喃,N-甲基吡咯烷酮,N,N-二甲基甲酰胺作为反应溶剂,化学反应 8.0H,反应生成 3-溴-5-(三氟甲基)吡啶
参考文献:Trifluoromethyl-Substituted Pyridines Through Displacement Of Iodine By In Situ Generated (Trifluoromethyl)Copper
标题:Trifluoromethyl-Substituted Pyridines Through Displacement Of Iodine By In Situ Generated (Trifluoromethyl)Copper
摘要:
DOI:10.1002/1099-0690(20021)2002:2<327::Aid-Ejoc327>3.0.Co;2-V

海关参考信息

2933310010-吡啶
2903399090-其他无环烃卤化衍生物
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-7884125-B2
优先权日:2008-04-30
标题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-2009275616-A1
优先权日:2008-04-30
标题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

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