CAS: 50-41-9; Clomiphene Citrate

上下游产品

2-{4-(1,2-diphenylethenyl)phenoxy}-N,N-diethylethanamine hydr°Chloride citric acid clomipheneclomiphene citrate cis-clomiphene citrate

氯米芬,柠檬酸 以 乙醇 作为反应溶剂,化学反应 0.08H,以30.8 G的收率获得产物克罗米芬
参考文献:一种恩氯米芬的制备方法
标题:一种恩氯米芬的制备方法
摘要:本发明涉及一种恩氯米芬的制备方法,包括:(1)克罗米芬或其盐,消旋联萘酚磷酸酯于含有醚类溶剂的醇类溶剂中反应,得到固体形式的恩氯米芬与联萘酚磷酸酯复合物;(2)将固体形式的恩氯米芬与联萘酚磷酸酯复合物经游离反应制得恩氯米芬.通过使用含有醚类溶剂的醇类溶剂作为拆分溶剂,恩氯米芬与拆分剂可形成固体复合物直接从拆分溶剂中析出,改善了反应体系的流动性,提供了一种拆分收率高,拆分产品纯度高,成本低,环境污染小,具有较好的工业应用前景的恩氯米芬的制备方法.

专利信息

专利号:US-9180171-B2
优先权日:2011-01-25
标题 :Method of regulating fertilizing ability using cyclic ADP-ribose and CD38
发明人：KIM UH-HYUN; PARK KWANG-HYUN; KIM BYUNG-JU
权利人:NAT UNIV CHONBUK IND COOP FOUND
摘要:The present invention relates to a pharmaceutical composition for promoting fertilization comprising cyclic ADP-ribose or its derivative, CD38 and to a method of promoting fertilization by promoting the synthesis of cyclic ADP-ribose to increase sperm motility. Also, the present invention relates to a pharmaceutical composition for contraception and a method for inhibiting fertilization, which can inhibit the expression or function of cyclic ADP-ribose to reduce sperm motility, thereby inhibiting fertilization.

专利号:US-2005053642-A1
优先权日:2000-08-23
标题:Biocompatible materials
发明人：ULBRICHT MATHIAS; THOM VOLKMAR; JANKOVA KATJA; ALTANKOV GEORGE; JONSSON GUNNAR
摘要:The present invention teaches a novel approach of creating biocmpatible surfaces, said surfaces being capable of functionally interact with biological material. SAid biocompatible surfaces comrise at least two comonents, such as a hydrophobic substratum and a macromolecule of hydrophilic nature, which, in a cooperativity, form together the novel biocoompatible surfaces. The novel approach is ased on contacting said hydrophobic substratum with a laterally patterned monomolecular layer of said hydrophilic and flexible macromolecules, exhibiting a pronounced excluded volume. The htus formed two component surface is, in respect to polarity and morphology, a molecularly heterogeneous surface. Structural features of said macromolecular monolayer (as e.g. the layer thickness or its lateral density) are determined by: i) the structural features of the layer forming macromolecules (as e.g. their MW or their molecular architecture) and ii) the method of creating said monomolecular layer (as e.g. by physi- or chemisorbing, or by chemically binding said macromolecules). The structural features of the layer forming macromolecules(s) is in turn determined by synthesis. AMount and conformation and thus also biological activity of biological material (as e.g. polypeptides) which contact the novel biocompatible surface, is determined and maintained by the cooperative action of the underlying hydrophobic substratum and the macromolecular layer. In this way it becomes possible to maintain and control biological interactions between said contacted polypeptides and other biological compounds as e.g. cells, antibodies and the like. Consequently, the present invention aims to reduce and/or eliminate the deactivation and/or denaturation associated with the contacting of polypeptides and/or other biological material to a hydrophobic substratum surface.

专利号:US-6403576-B1
优先权日:1998-08-24
标题 :Antifungal and antiparasitic compounds
发明人：JACKSON JOAN E; IWU MAURICE M; OKUNJI CHRISTOPHER O; BACCHI CYRUS; TALLY JR JOHN D; AYAFOR JOHNSON F
权利人:US ARMY
摘要:Novel antiparasitic and antifungal compositions are disclosed. The antiparasitic and antifungal compositions are useful for human and veterinary therapy for the treatment and/or prevention of parasitic infection. Also disclosed are novel mechanisms of identifying antifungal and antiparasitic compositions by their biochemical action on lipid synthesis and/or metabolism and/or excretion.

专利号:PT-1883451-E
优先权日:2005-04-13
标 题 :SUBSTITUTED INDOOR COMPOUNDS WITH INHIBITORY ACTIVITY OF NITRIC OXIDE SYNTHESIS (NOS)