CAS: 50715-50-9; Boc-Asp(Otbu)-Osu

相似化合物

32886-55-8 3392-09-4 3392-12-9

上下游产品

CAS号6066-82-6 N-羟基琥珀酰亚胺 | CAS号1676-90-0 叔丁氧羰基-L-天冬氨酸-4-叔丁酯 | CAS号153287-86-6 B°C-L-天冬氨醇-4-叔丁酯

N-羟基丁二酰亚胺,叔丁氧羰基-L-天冬氨酸-4-叔丁酯置于盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 22.0H,反应生成 Boc-L-天门冬氨酸4-叔丁基-1-羟基-琥珀酰亚胺酯
参考文献:Functional Profiling Of Adenylation Domains In Nonribosomal Peptide Synthetases By Competitive Activity-Based Protein Profiling
标题:Functional Profiling Of Adenylation Domains In Nonribosomal Peptide Synthetases By Competitive Activity-Based Protein Profiling
摘要:利用磺胺氧基连接的氨酰-Amp类似物库,我们描述了竞争性活性蛋白质分析技术,以直接促进在蛋白质组学环境中对非核糖体肽合成酶中腺苷化结构域的功能预测和评估.
DOI:10.1039/c5Cc04953A

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-9957291-B2
优先权日:2013-08-05
标题 :Protected fluorescent reagent compounds
发明人：SEBO LUBOMIR; HANES JEREMIAH; SHEN GENE; BROGLEY LOUIS; YUE STEPHEN; ZHENG FRANK; LAPIN YURI; LYLE JOHN; OSUNA HONEY; FEDOROV ANDREI
权利人:PACIFIC BIOSCIENCES CALIFORNIA INC
摘要:Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.

专利号:US-10787573-B2
优先权日:2015-02-04
标 题:Multimeric protected fluorescent reagents
发明人：ZHENG FRANK; HANES JEREMIAH; SHEN GENE; BROGLEY LOUIS; YUE STEPHEN; LAPIN YURI; LYLE JOHN; OSUNA HONEY; FEDOROV ANDREI; SEBO LUBOMIR
权利人:PACIFIC BIOSCIENCES CALIFORNIA INC
摘要:Multimeric protected fluorescent reagents and their methods of synthesis are provided. The reagents are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The reagents contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. The reagents also contain coupling elements connect monomeric compounds into multimeric forms, thereby increasing brightness.