CAS: 573-11-5; 2,3,4-Trimethoxybenzoic Acid

该化合物是一种芳香的碳酸,其特点是附于苯酸结构的三种甲氧基组(-OCH3),甲氧基组位于苯环上的2,3和4个位置,有助于化合物的独特化学特性.该化合物一般是白色的脱白晶状固体,在有机溶剂中可溶解,而其溶解于水中的溶解性由于甲氧基组的疏水性质而受到限制.它表现出中等酸性,典型的碳氧酸,可以参与各种化学反应,包括酯化和细胞化.多种甲氧基组的存在可增强它的再活动,影响其生物活动,使其对医药化学和有机合成具有兴趣.此外,2,3,4-三氧化乙基苯乙酸可能表现出抗氧化特性,并有可能应用于医药和农用化学化学物质.安全数据应当用于处理和使用,如同所有化学物质一样.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号2103-57-3 2,3,4-三甲氧基苯甲醛 | CAS号634-36-6 1,2,3-三甲氧基苯 | CAS号141-82-2 丙二酸 | CAS号43020-38-8 2,3,4-三甲氧基苯甲腈 | CAS号5653-46-3 2-羟基-3,4-二甲氧基苯甲酸 | CAS号77-78-1 硫酸二甲酯 | CAS号13909-73-4 2',3',4'-三甲氧基苯乙酮 | CAS号6395-18-2 methyl 2,3,4-tr... | CAS号4082-16-0 2',3',4'-trimet... | CAS号110144-76-8 (4,5,6-triacety... | CAS号5653-46-3 2-羟基-3,4-二甲氧基苯甲酸 | CAS号1968-72-5 methyl 6-amino-... | CAS号71989-96-3 2,3,4-三甲氧基苯甲醇 | CAS号13082-16-1 9(10H)-Acridino... | CAS号649551-96-2 [5-decyl-2-(2-m... | CAS号7143-46-6 2-(2,3,4-trimet... | CAS号7169-07-5 2,3,4-TRIMETHOX... | CAS号77256-02-1 2-异丙基-3,4-二甲氧基苯甲醛 | CAS号88440-82-8 N,N-diethyl-2,3...

合成工艺路线路线简述

    1,2,3-三甲氧基苯置于n-Dodecyllithium,Petroleum Ether体系中,化学反应生成 2,3,4-三甲氧基苯甲酸
    参考文献:Meals,Journal Of Organic Chemistry,1944,Vol. 9,P. 212
    标题:Meals,Journal Of Organic Chemistry,1944,Vol. 9,P. 212

    海关参考信息

    专利信息


    专利号:US-4400550-A
    优先权日:1982-02-12
    标题 :Synthesis of the navel orange worm pheromone (Z,Z)-11,13-hexadecadienal
    发明人:BISHOP CLYDE E; MORROW GARY W
    权利人:ALBANY INT CORP
    摘要:A process for the synthesis of (Z,Z)-11-13-hexadecadienal is disclosed, starting with undecylenic alcohol.

    专利号:US-7468438-B2
    优先权日:2004-03-25
    标题:Process for the semisynthesis of deserpidine
    发明人:FONTANA GABRIELE; BOMBARDELLI EZIO; SAMORI CRISTIAN; BALDELLI ELEONORA; GUERRINI ANDREA; BATTAGLIA ARTURO; DANIELI BRUNO
    权利人:INDENA SPA
    摘要:The present invention relates to an efficient procedure for the synthesis of deserpidine (Ia), starting from reserpic acid lactone (II) via the intermediate 11-O-demethyl reserpic acid lactone (III).

    专利号:WO-9834113-A1
    优先权日:1997-02-04
    标题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
    发明人:OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; HOUGHTEN RICHARD A; BLONDELLE SYLVIE E; SCHONER CHRISTA C
    权利人:TREGA BIOSCIENCES INC
    摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-8273403-B2
    优先权日:2002-05-10
    标题 :Generation of surface coating diversity
    发明人:BARDEN MICHAEL C; KAMBOURIS PETER A
    权利人:BARDEN MICHAEL C; KAMBOURIS PETER A; BIO LAYER PTY LTD
    摘要:This invention relates to a surface discovery system and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. The system is built upon a synthon which comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a copolymer (B) of at least one passive constituent (P) and at least one active constituent (A); a spacer unit (S) separating the backbone from a functional group; and a functional group (F). The methods comprise the following steps: 1) selecting a plurality of synthons so that each synthon has at least two points of diversity selected from P, A, S and F; 2) applying copolymer B onto a substrate; and 3) attaching a combination of S and F to constituent A of copolymer B. Steps 2) and 3) are performed such that different synthons are generated on localized regions of the substrate.

    专利号:US-RE29558-E
    优先权日:1973-03-06
    标 题:Lincomycin analogs
    摘要:Compounds of the formula: ##STR1## are disclosed, wherein R 1 taken independently is hydrogen; R 2 taken independently is the moiety ##STR2## wherein Ac is carboxacyl or an acyl group of formula: ##STR3## wherein Z is hydrogen, lower alkyl or a protective group removable by hydrogenolysis; R 5 is lower alkyl; R 1 and R 2 when together are the divalent group; ##STR4## wherein Z and R 5 are as defined above; R 3 is hydrogen when R 1 and R 2 are taken together and is a monovalent thio group of formula: ##STR5## located in the 7(S)-position when R 1 and R 2 are taken independently, A represents hydrogen or hydroxyl, B represents hydrogen or hydroxyalkyl, n is the integer 0 when B is hydroxyalkyl and n is an integer of 0 to 1, inclusive, when B is hydrogen, X is oxygen .[.or sulfur.]., D is the acyl radical of a lower hydrocarbon carboxylic acid; R 4 is lower alkyl and Y is carboxacyl or hydrogen. n Disclosed also are methods of making and using the novel compounds of the invention, which are useful intermediates in the chemical synthesis of useful antibacterial lincomycin analogs. Certain of the compounds of the invention are also active as antibacterial agents.
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    主要参考文献

    参考标题:Pd(II)/cu(II)-Catalyzed Regio- And Stereoselective Synthesis Of (E)-3-Arylmethyleneisoindolin-1-Ones Using Air As The Terminal Oxidant
    作者:So Won Youn,Tae Yun Ko,Young Ho Kim,Yun Ah Kim |发布日期:2018.12.21
    摘要:Regio- And Stereoselective Synthesis Of (E)-3-Arylmethyleneisoindolin-1-Ones Via Pd(II)/cu(II)-Catalyzed One-Pot C-C/c-N Bond Forming Sequence Between Amides And Styrenes Is Reported. This Method Provides Facile And Rapid Access To A Diverse Range Of Such Compounds Using Readily Available Starting Materials Under Mild Aerobic Conditions With Good Functional Group Tolerance And High Selectivity And Efficiency

    合成参考文献


    摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 96.
    摘要:Zhang, M.; Su, W., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 113.
    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    摘要:Arun, V.; Saha, S. K.; De Sarkar, S., Science of Synthesis: Cross-Dehydrogenative Coupling, (2023) nan, 365.
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