专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:US-2016073631-A1 优先权日:2013-03-04 标 题 :Process for the preparation of dihydropyrrole derivatives 发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS 权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD 摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).
专利号:US-9233920-B2 优先权日:2010-06-11 标题 :Process for the preparation of dihydropyrrole derivatives 发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS 权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD 摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).
专利号:WO-2011067757-A1 优先权日:2009-12-06 标题 :INSECTICIDAL COMPOSITIONS OF CHITIN SYNTHESIS INHIBITORS (CSIs) AND THE ENTOMOPATHOGENIC FUNGUS NOMURAEA RILEYI 发明人:APPLEBAUM SHALOM W; ICHELCZIK DANA; BARAZANI AVNER 权利人:MAKHTESHIM CHEM WORKS LTD; YISSUM RES DEV CO; APPLEBAUM SHALOM W; ICHELCZIK DANA; BARAZANI AVNER 摘要:The present invention discloses a pesticidal composition comprising a combination of a chitin synthesis inhibitor (CSI) and the fungus Nomuraea rileyi, wherein this composition is insecticidally effective and contains an insecticidally effective amount of a chitin synthesis inhibitor and an insecticidally effective amount of the fungus Nomuraea rileyi. Also are disclosed a method of treating or preventing pest infestation in a plant or in an environment in which this plant is grown, by contacting the plant or environment with the pesticidal composition of the invention, and a method for reducing the amount of CSI required to control insects, and the use of the pesticidal composition of the invention in controlling insects in a plant or an environment of the plant.
专利号:US-7628979-B1 优先权日:2005-04-20 标题 :Use of calco oil blue V in bait formulations for marking and controlling subterranean termites 发明人:MORALES-RAMOS JUAN A; ROJAS MARIA G 权利人:US AGRICULTURE 摘要:Termite bait matrix containing cellulose, calco oil blue V (solvent blue 58 or 9,10-anthracenedione, 1,4-bis[(2-ethylhexyl)amino]), and optionally a termite toxicant (e.g., chitin synthesis inhibitor). Methods of monitoring termite activity in a region involving placing a termite bait matrix in the region and assessing the presence of termites at the site of the termite matrix, the termite bait matrix contains cellulose and 9,10-anthracenedione, 1,4-bis[(2-ethylhexyl)amino]. Methods of killing termites, involving placing a termite bait matrix in a termite habitat and allowing termites to feed on the bait matrix, the termite bait matrix contains cellulose, 9,10-anthracenedione, 1,4-bis[(2-ethylhexyl)amino], and a termite toxicant (e.g., chitin synthesis inhibitor).
专利号:US-6555120-B1 优先权日:1998-10-21 标题:Isolation, structural determination, synthesis, biological activity and application as control agent of the host marking pheromone (and derivatives thereof) of the fruit flies of the type anastrepha (diptera: tephritidae) 发明人:ALUJA-SCHUNEMAN MARTIN RAMON; DIAZ-FLEISCHER FRANCISCO; EDMUNDS ANDREW J F; HAGMANN LEONHARD 权利人:INST DE ECOLOGIA A C 摘要:The 2-(2,14-Dimethyl-pentadecanoylamin)-pentanedioic acid (I) and compounds of the formula (II), n wherein the substituents have the meaning disclosed in the specification, are used as oviposition deterring pheromones against the following fruit flies (Diptera: Tephritidae) of economical importance: Anastrepha fraterculus (south America fruit fly), A. grandis, A. ludens (Mexican fruit fly), A. obliqua (mango fly), A. serpentina (sapodilla fly), A. striata (guayabi fly) and A. suspensa (Caribbean fruit fly). The above-mentioned substances, if conveniently formulated, can be used to reduce the damage caused by these insects to fruits which are cultivated in commercial and semi-commercial orchards, in garden orchards and in isolated trees in residential gardens.
参考文献:10.1021/jf9034282 摘要:Xia K, Atkins J, Foster C, Armbrust K. Analysis of cyromazine in poultry feed using the QuEChERS method coupled with LC-MS/MS. J Agric Food Chem. 2010 May 26;58(10):5945–9. doi: 10.1021/jf9034282. 参考文献:10.1007/s00216-011-5237-3 摘要:Krska R, Becalski A, Braekevelt E, Koerner T, Cao X, Dabeka R, Godefroy S, Lau B, Moisey J, Rawn DFK, Scott PM, Wang Z, Forsyth D. Challenges and trends in the determination of selected chemical contaminants and allergens in food. Analytical and Bioanalytical Chemistry. 2011 Jul 20;402(1):139–62. doi: 10.1007/s00216-011-5237-3.