CAS: 696-54-8; Isonicotinaldehyde Oxime

相似化合物

872-85-5 1193-92-6 1637-52-1

上下游产品

CAS号872-85-5 4-吡啶甲醛 | CAS号108-89-4 4-甲基吡啶 | CAS号144605-36-7 3-Pyridinecarbo... | CAS号54751-01-8 4-溴甲基吡啶 | CAS号56-97-3 双解磷 | CAS号104786-54-1 [1-(3-hydroxypr... | CAS号3731-53-1 4-甲氨基吡啶 | CAS号23974-15-4 4-乙酰氨基甲基吡啶 | CAS号100-48-1 4-氰基吡啶 | CAS号1453-82-3 异烟碱 | CAS号244016-79-3 diethyl ((pyrid... | CAS号872-85-5 4-吡啶甲醛 | CAS号2196-13-6 硫代异烟酰胺 | CAS号74160-03-5 (1-hexadecylpyr... | CAS号78157-26-3 6-(吡啶-4-基)吡嗪-3(2H)-酮

4-甲基吡啶置于亚硝酸特丁酯,N-羟基邻苯二甲酰亚胺,Copper Diacetate体系中,用 乙腈 作为反应溶剂,化学反应 24.0H,以76%的收率获得产物4-吡啶甲醛肟
参考文献:Copper(II)-Promoted Direct Conversion Of Methylarenes Into Aromatic Oximes
标题:Copper(II)-Promoted Direct Conversion Of Methylarenes Into Aromatic Oximes
摘要:一个简单高效的催化体系已经开发出来,可以直接将甲基芳烃转化为芳香肟,使用cu(Oac)2作为催化剂,Nhpi(n-羟基邻苯二甲酰亚胺)作为添加剂,叔丁基硝rite(tbn)既作为氮源也作为氧化剂.该过程在温和条件下进行,能够容忍广泛的底物范围,以63-86%的收率获得产物相应的芳香肟.
DOI:10.1039/c5Ob00923E

专利信息

专利号:WO-2024186075-A1
优先权日:2023-03-03
标题 :Synthesis method of antibody-drug conjugates using proximity effect-based site-selective antibody labeling
发明人：LEE HYUN SOO; KIM SOOIN; KWEON YONGSEOK
权利人:UNIV SOGANG RES & BUSINESS DEVELOPMENT FOUND; RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIV
摘要:The present invention relates to a method for the synthesis of an antibody-drug conjugate using proximity effect-based site-selective antibody labeling. Provided according to the present invention may be a method for the synthesis of an antibody-drug conjugate by site-selectively introducing a drug into an antibody using a pyridinium oxime derivative (labeling mediator protein) introduced into a binding protein containing a non-standard amino acid.

专利号:US-5233044-A
优先权日:1989-06-08
标题:Active esters for solid phase peptide synthesis
发明人：HUDSON DEREK
权利人:MILLIPORE CORP
摘要:Derivatives of 1-phenyl pyrazolin-5-one have many applications for biomolecule synthesis. Enol esters of protected amino acids made by the present process provide efficient coupling in solid-phase peptide synthesis. The 1-phenyl-pyrazolin-5-one derivatives are highly crystalline, stable, non-toxic and easy to prepare. Many possess self-indicating properties, facilitating spectrophotometric monitoring and automation of peptide synthesis.

专利号:CN-107652242-B
优先权日:2017-10-09
标 题 :Synthesis of pyrimidine salicylic acid oxime ester and application of pyrimidine salicylic acid oxime ester as herbicide

专利号:CN-107652242-A
优先权日:2017-10-09
标题:A kind of synthesis of pyrimidine salicylic acid oxime ester and the application as herbicide

专利号:US-5130438-A
优先权日:1985-11-20
标 题 :Bis-methylene ether pyridinium compound preparation
发明人：HSIAO LUKE Y Y; MUSALLAM HIKMAT A
权利人:US ARMY
摘要:An illustrative embodiment of the invention substitutes solid, non-carcinogenic bis(methanesulfonoxymethyl) ether for bis-chloromethyl ether in a low temperature reaction of about 0°-5° C. for the production of bis-methylene ether pyridinium quaternary compounds. In this way, the production of important nerve agent antidotes (toxogonin, HI-6 and HGG-12) by a method of synthesis using the reactant bis-mesylmethyl ether, is carried out in appreciably greater safety.