CAS: 10431-98-8; 2-Ethyl-4,5-Dihydrooxazole

相似化合物

4694-80-8 10431-99-9 27031-10-3

上下游产品

N-(2-hydroxyethyl)propionamide thiopropionyl-carbamic acid ethyl ester ethanolamine propionic acid °Ctan5-Aethyl-3-phenyl-1-aza-4,6-dioxa-bicyclo3.3.0°Ctan 2-ethylidene-oxazolidine-3-carbonyl chloride 2-(4,5-dihydro-oxazol-2-yl)-propan-1-ol N-(4-methylphenyl)-N'-propionylethylenediamine

N-(2-羟乙基)酰丙胺 反应生成2-乙基-2-唑啉
参考文献:Process For Preparing 2-Oxazolines
标题:Process For Preparing 2-Oxazolines
摘要:描述了一种用于制备2-噁唑啉的环脱水反应,包括在液相中反应(a)n-(2-羟基烷基)羧酰胺和(b)少量但具有催化作用的含铁化合物.该反应通常在升温条件下进行(例如180-200摄氏度),并在减压下进行.通过这种方法制备了2-H-和2-取代的2-噁唑啉.例如,通过在约180-200摄氏度/50毫米汞柱下将适当的n-(2-羟基乙基)羧酰胺与四水合氯化亚铁接触,分别制备了83.1%和90.2%产率的2-H-2-噁唑啉和2-乙基-2-噁唑啉.在这些条件下,噁唑啉产物和水基本上与它们形成的速度一样快地从反应混合物中共蒸馏出来.

专利信息

专利号:WO-2025008139-A1
优先权日:2023-07-06
标题 :Process for the continuous synthesis of polyoxazolines using a spiral tube reactor
发明人：WEGENER ERIK; JORDAN RAINER; KIRCHHOF LISA; THOMAS ANITA
权利人:UNIV DRESDEN TECH
摘要:The invention relates to the continuous synthesis of polyoxazolines. The invention also relates to a process for the continuous synthesis of polyoxazolines comprising the step of: conducting at least one oxazoline monomer through a spiral tube reactor under the influence of heat, the spiral tube reactor comprising a helically-wound tube having a tube inner diameter and a diameter of the helical winding, characterised in that: • the tube inner diameter is 4.5 mm to 34 mm and the lambda ratio, as the ratio of the tube inner diameter to the diameter of the helical winding, is in the range of 0.11-0.17, and • the helically-wound tube is a stainless steel tube. The invention also relates to the use of a spiral tube reactor for the continuous synthesis of polyoxazolines, the spiral tube reactor comprising: a helically-wound tube having a tube inner diameter and a diameter of the helical winding, characterised in that: • the tube inner diameter is 4.5 mm to 34 mm and the lambda ratio, as the ratio of the tube inner diameter to the diameter of the helical winding, is in the range of 0.11-0.17, and • the helically-wound tube is a stainless steel tube.

专利号:US-7344863-B2
优先权日:1998-03-13
标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
发明人：LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
权利人:INVITROGEN CORP
摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.

专利号:US-11407993-B2
优先权日:2017-02-14
标 题 :Method for the synthesis of DNA conjugates by micellar catalysis
发明人：BHAT AVINASH SHASHIDHAR; KLIKA SKOPIC MATEJA; BRUNSCHWEIGER ANDREAS; WEBERSKIRCH RALF
权利人:UNIV DORTMUND TECH
摘要:A method for the synthesis of a chimeric conjugate molecule by micellar catalysis that may form part of DNA-encoded compound libraries. A DNA-coupled organic starter molecule may be reacted with another organic compound, using a catalyst located within a micelle, to form a conjugate of an organic candidate compound coupled to a DNA identifier tag.

专利号:US-2019016909-A1
优先权日:2016-01-11
标题:Template synthesis of polymeric nanomaterials by ink-jet printing
发明人：PHILLIP WILLIAM A; QU SIYI; BENAVIDES SHERWOOD; GAO PENG; GAO FENG
权利人:UNIV NOTRE DAME DU LAC
摘要:A method for fabricating nanostructured polymeric materials based on a combination of inkjet printing and template synthesis. Layer-by-layer assembled nanotubes can be synthesized in a polycarbonate track-etched (PCTE) membrane by printing poly(allylamine hydrochloride) (PAH) and poly(styrenesulfonate) (PSS) sequentially. By changing the printing conditions, polymeric nanotubes or nanowires can be prepared by printing poly(vinyl alcohol) (PVA) in a PCTE template. Inkjet printing paired with template synthesis can be used to generate patterns comprised of chemically distinct nanomaterials. Thin polymeric films of layer-by-layer assembled PAH and PSS can be printed on a PCTE membrane. Inkjet printing paired with template synthesis can also be used to prepare functional mosaic membranes, such as charge mosaic membranes comprising polyelectrolytes of different charges to pattern positively charged or negatively-charged domains, respectively, on the surface of the template.

专利号:US-2012301720-A1
优先权日:2009-11-16
标题 :Metal island coatings and method for synthesis
发明人：KOBAN WIELAND; PEUKERT WOLFGANG; KLUPP TAYLOR ROBIN; DISTASO MONICA; BAO HUIXIN; VASYLYEV SERHIY
权利人:KOBAN WIELAND; PEUKERT WOLFGANG; KLUPP TAYLOR ROBIN; DISTASO MONICA; BAO HUIXIN; VASYLYEV SERHIY; BASF SE
摘要:The present invention relates to methods for synthesis of metallic island coatings with tunable island coverage and morphology on a variety of substrates. Particularly, the present invention relates to substrates coated with one or more metal islands and the use of said island-coated substrates.

专利号:US-11766432-B2
优先权日:2018-07-27
标题 :Cleavable conjugates of catechol compounds and water-soluble polymers and methods of treatment using the same
发明人：BENTLEY MICHAEL; FANG ZHIHAO; WEIMER REBECCA; VIEGAS TACEY; MOREADITH RANDALL
权利人:SERINA THERAPEUTICS INC
摘要:Described are conjugates comprising a water-soluble polymer linked to a compound comprising a catechol moiety via a cleavable linkage, wherein the cleavable linkage is formed between the water-soluble polymer and a first phenolic hydroxyl group of the catechol moiety and a second phenolic hydroxyl group of the catechol moiety is linked to a blocking group wherein the rate of hydrolytic release of the compound comprising the catechol moiety is controlled, at least in part, through structure or design of the blocking group on the second phenolic hydroxyl group of the catechol moiety. Therefore, the rate of hydrolytic release of the compound comprising the catechol moiety can be tuned through structural design of the group on the second phenolic hydroxyl group of the catechol moiety. Compounds used in the synthesis of the described conjugates and methods of using the described conjugate and other compounds in the treatment of dopamine-responsive disorders are also described.