专利号:WO-2021014395-A1 优先权日:2019-07-24 标题:Process for the synthesis of deuterated capsaicin, capsaicinoids and synthetic capsaicin analogs 发明人:ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT 权利人:DR REDDY’S INST OF LIFE SCIENCES 摘要:The present application provides novel processes for the synthesis of deuterated intermediates of capsaicinoids, particularly II, III, IV and V of capsaicinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V.
专利号:US-4351767-A 优先权日:1981-06-29 标题 :Synthesis of 24,25-dihydroxycholesterol 发明人:KAISER EMIL T 权利人:KAISER EMIL T 摘要:This invention relates to the synthesis of steroids which are useful for their biological activity or which may be converted to steroids which have such activity. More particularly, the invention pertains to the synthesis of 24,25-dihydroxycholesterol. It includes intermediate sterols of this synthesis and processes for their preparation.
专利号:US-4250330-A 优先权日:1977-04-13 标题:Process for the recovery of the solvent and of the by-produced methylacetate in the synthesis of terephthalic acid 发明人:COSTANTINI GIUSEPPE; PAOLI PIETRO; SERAFINI MAURO 权利人:MONTEDISON SPA 摘要:The invention refers to an improved process for the recovery of the solvent and of the by-produced methylacetate in the synthesis of terephthalic acid, said synthesis being usually consisting of an oxidation of paraxylene with air, in the presence of a catalyst system composed by cobalt, manganese and bromine, in a solvent consisting of acetic acid, according to the equation (1): n n C.sub.6 H.sub.4 (CH.sub.3).sub.2 +3 O.sub.2 →C.sub.6 H.sub.4 n n (COOH) 2 =2 H 2 O (1) n More particularly, the improved process of this invention comprises the oxidation of para-xylene in acetic acid solution and in the presence of a catalytic system based on manganese, bromine and cobalt, whereby water is formed and methylacetate is by-produced during the oxidation, whereby solid terephthalic acid is separated from the mother liquor and whereby one withdraws from the oxidation zone a liquid which is obtained by condensing the vapors released during the oxidation and which are mainly consisting of acetic acid and water, the improvement consisting of the fact that: n (a) the liquid obtained by condensing the released vapors and said mother liquor are fed both to an azeotropic distillation system in which the azeotropic agent is isobutyl-acetate; n (b) the light ends of the azeotropic distillation, richer in water, are condensed and demixed into two phases, wherein the aqueous phase, which is lower and contains isobutyl-acetate and methyl-acetate, is conveyed to a stripping, whereby isobutyl-acetate and methyl-acetate are recovered, and wherein the organic phase is recycled to the azeotropic distillation.
专利号:WO-2023166160-A1 优先权日:2022-03-04 标 题:Process for synthesis of 1,4-dihydronicotinamide riboside (nrh) from nicotinamide-beta-riboside triacetate chloride (nra-cl) 发明人:MALKANNAGARI RAMANI; GUNDAPUNENI RAGHAVA RAO; BOHAN FRODE 权利人:BOHAN & CO AS 摘要:The present invention disclose novel process for synthesis of 1,4- dihydronicotinamide riboside (NRH). More particularly, the invention discloses a cost-effective synthesis of 1, 4-dihydronicotinamide riboside (NRH) from Nicotinamide-beta-riboside triacetate chloride (NRA-CI) in good yields and purity comprising the steps of a) reducing Nicotinamide-beta-riboside triacetate chloride (NRA-CI) in presence of non-chlorinated aprotic organic solvent and a reducing agent to obtain 1,4-dihydronicotinamide riboside triacetate (NRH-A); and b) deacetylating the 1,4-dihydronicotinamide riboside triacetate (NRHA) in presence of a base to obtain 1,4-dihydronicotinamide riboside(NRH)
专利号:US-4720573-A 优先权日:1986-07-31 标 题:Process for synthesis of glutamic acid from acrylate, amide and synthesis gas 发明人:LIN JIANG-JEN 权利人:TEXACO INC 摘要:A process for the synthesis of glutamic acid intermediate from an acrylate, amide and syngas by reacting them in the presence of a catalyst comprising a cobalt-containing compound, a bis-phosphine ligand and a solvent at a pressure of at least 500 psi and a temperature of at least 50° C. and thereafter extracting the glutamic acid.
专利号:WO-2024084491-A1 优先权日:2022-10-21 标题:Process for synthesis of res metirom and its intermediates thereof 发明人:MEHTA NILESH VIPINCHANDRA 权利人:MEHTA NILESH VIPINCHANDRA 摘要:The present invention discloses a process for synthesis of Res metirom and its intermediates thereof. More particularly, the invention discloses process for synthesis of a key intermediate, 6-(4-amino, 2,6-dichlorophenoxy)4- isopropylpyridazin-3(2H)-one, of Res metirom via novel intermediate compounds of formula A. Wherein, R is selected from methyl, ethyl and propyl.
[参考文献]: Shan G, Et Al. Purification Of Total Dna Extracted From Activated Sludge. J Environ Sci (China). 2008;20(1):80-87. [参考文献]: Sokolov Bp, Et Al. Vydelenie Vysokomolekuliarnoĭ éukarioticheskoĭ Dnk S Ispol'Zovaniem Atsetata Kaliia [参考文献]: Mol Gen Mikrobiol Virusol. 1989;(6):45-46. [参考文献]: Alexander G Myasnikov, Et Al. The Molecular Structure Of The Left-Handed Supra-Molecular Helix Of Eukaryotic Polyribosomes. Nat Commun. 2014 Nov 7:5:5294. [参考文献]: Chantell Wilson, Et Al. The Paracrine Hormone For The Gucy2C Tumor Suppressor, Guanylin, Is Universally Lost In Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2014 Nov;23(11):2328-37. [参考文献]: Coilín Boland#, Et Al. Cell-Free Expression And In Meso Crystallisation Of An Integral Membrane Kinase For Structure Determination. Cell Mol Life Sci. 2014 Dec;71(24):4895-4910.
合成参考文献
参考文献:10.1007/978-1-61779-188-8_15 摘要:Bhardwaj R, Krautz-Peterson G, Skelly PJ. Using RNA interference in Schistosoma mansoni. Methods Mol Biol. 2011;764():223–39. doi: 10.1007/978-1-61779-188-8_15. 参考文献:10.1038/ncomms1383 摘要:Nery FC, Armata IA, Farley JE, Cho JA, Yaqub U, Chen P, da Hora CC, Wang Q, Tagaya M, Klein C, Tannous B, Caldwell KA, Caldwell GA, Lencer WI, Ye Y, Breakefield XO. TorsinA participates in endoplasmic reticulum-associated degradation. Nature Communications. 2011 Jul 12;2(1):393. doi: 10.1038/ncomms1383. 参考文献:10.1007/978-1-61779-252-6_10 摘要:Telley IA, Bieling P, Surrey T. Reconstitution and quantification of dynamic microtubule end tracking in vitro using TIRF microscopy. Methods Mol Biol. 2011;777():127–45. doi: 10.1007/978-1-61779-252-6_10. 参考文献:10.1007/s00425-011-1483-z 摘要:Liao YW, Shi K, Fu LJ, Zhang S, Li X, Dong DK, Jiang YP, Zhou YH, Xia XJ, Liang WS, Yu JQ. The reduction of reactive oxygen species formation by mitochondrial alternative respiration in tomato basal defense against TMV infection. Planta. 2012 Feb;235(2):225–38. doi: 10.1007/s00425-011-1483-z.