CAS: 132388-68-2; Boc-Asn(Trt)-Oh

相似化合物

210529-01-4 2044709-67-1 2044711-09-1

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CAS号76-84-6 三苯基甲醇 | CAS号132388-57-9 N-苄氧羰基-N'-三苯甲基-... | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号132388-58-0 N'-(三苯甲基)-L-天冬酰胺

三苯基甲醇置于palladium On Activated Charcoal 硫酸,氢气,乙酸酐体系中,用 溶剂黄146 用作溶剂,化学反应 1.0H,反应生成叔丁氧羰基-N-Beta-三苯甲基-L-天门冬酰胺
参考文献:三苯甲基残基保护羧酰胺功能.在肽合成中的应用
标题:三苯甲基残基保护羧酰胺功能.在肽合成中的应用
摘要:羧酰胺官能团可以通过在冰醋酸中与三苯甲醇和乙酸酐进行酸催化反应来三苯甲基化.天冬酰胺和谷氨酰胺的ω-三苯甲基可被tfa裂解,但对水溶液中的强无机酸以及亲核试剂和碱稳定.在肽合成中,它非常适合与叔丁基类型的侧链保护结合使用.
Doi:10.1016/s0040-4039(00)74872-6

专利信息

专利号:US-2023242581-A1
优先权日:2020-06-17
标题:Synthesis of a guanylate cyclase agonist by fragments based approach
发明人：SAMBASIVAM GANESH; KASTURCHAND GODHA ATUL; VENKATA BHAGYARAJ ARETI; ANNADURAI SATHYA; VEERANJANEYULU AVULA; VASANTRAO GADAKH AMOL; S JADHAV DIPAK
权利人:ANTHEM BIOSCIENCES PRIVATE LTD
摘要:The present invention provides a process for the synthesis of Plecanatide, a guanylate cyclase agonist. The process involves convergent synthesis with compounds, i.e., fragment of peptides followed by cyclization. The method provides high yield of Plecanatide with less impurities.

专利号:US-2018265547-A1
优先权日:2014-07-18
标 题 :Z-selective olefin metathesis of peptides
发明人：MANGOLD SHANE L; GRUBBS ROBERT H
权利人:CALIFORNIA INST OF TECHN
摘要:The invention relates generally to the synthesis of modified amino acids and modified peptides in the presence of cyclometalated catalysts. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

专利号:US-12162957-B2
优先权日:2018-12-08
标 题:Process for the preparation of plecanatide
发明人：ADAK SANDIP; BONTE MANOJ; KULKARNI CHANDRAKANT; SWAMY VEERANARAYANA; JOGDAND NIVRUTTI; GADGIL HIMANSHU
权利人:ENZENE BIOSCIENCES LTD
摘要:A process for the preparation of plecanatide. Specifically, an improved process for preparation of plecanatide using a non-linear solid phase peptide synthesis. In particular, the process for preparation of plecanatide involves solid phase synthesis of peptide fragments of five amino acid units using 2-chlorotrityl chloride (2-ClTrt) resin and eleven amino acid unit using Wang resin.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:CN-111825742-B
优先权日:2019-04-18
标题:CTPA is used as a special coupling agent for solid-phase synthesis of peptides with amino acid ionic liquids

专利号:WO-2025015659-A1
优先权日:2023-07-18
标题 :Method for synthesizing amide and/or polypeptide by taking transiently protected amino acid as ammonia component
发明人：ZHAO JUNFENG; WANG PENGHUI; LIU TAO
权利人:UNIV GUANGZHOU MEDICAL
摘要:Provided is a method for synthesizing amide and/or polypeptide by taking a transiently protected amino acid as an ammonia component. In the method, an allenone compound is taken as a condensation reagent, a silylating reagent is used for temporarily protecting a carboxyl group of an amino acid or peptide fragment of which amino and carboxyl groups are not protected, then an α-carbonyl alkenyl ester derivative of another molecular carboxylic acid, or amino acid, or a C-terminal carboxyl group of a polypeptide is used together with same to form an amide bond, and then the temporarily protected carboxyl group can be subjected to on-site deprotection under an acidic condition to obtain a target carboxylic acid product, so as to cyclically construct a new amide bond. The allenone condensation agent can effectively avoid racemization, and the 'temporary protection' strategy enables the three-step reaction of 'protection-condensation-deprotection' to be carried out in one pot, so that greatly excessive chemical reagents, time, manpower and energy consumption required when protecting groups are introduced and protecting groups are removed are avoided, thereby improving the step economy and atom economy of polypeptide synthesis.