CAS: 20306-75-6; N-Methyl-3-Oxobutanamide

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CAS号76234-89-4 N-methyl-2-amin... | CAS号67-56-1 甲醇 | CAS号10128-60-6 3,6-dimethyl-1,... | CAS号96-31-1 1,3-二甲基脲 | CAS号541-50-4 3-氧丁酸 | CAS号674-82-8 双乙烯酮 | CAS号74-89-5 氨基甲烷 | CAS号107292-92-2 N-acetoacetyl-N... | CAS号7732-18-5 水

氯代乙酰乙酰甲胺置于potassium Carbonate,4-甲苯硫酚体系中,用 乙腈 用作溶剂,化学反应 0.75H,以100%的收率获得n-甲基乙酰基乙酰胺
参考文献:在 K+/ch3Cn 体系中使用苯硫醇对 α-卤代羰基化合物进行还原脱卤的简便方法
标题:在 K+/ch3Cn 体系中使用苯硫醇对 α-卤代羰基化合物进行还原脱卤的简便方法
摘要:图形摘要 摘要 苯硫醇作为各种 α-卤代羰基化合物脱卤的还原剂,在 K+/ch3Cn 系统中进行了研究.该反应在温和的反应条件下以高产率提供还原的化合物,尤其是 α-氯代羰基化合物.此外,在超声波照射下进行的反应大大缩短了反应时间.
Doi:10.1080/10426507.2016.1138309

专利信息

专利号:CN-108863834-A
优先权日:2018-08-13
标题:A new method for the synthesis of 2-fluoro-1,3-dicarbonyl compounds

专利号:US-10570157-B2
优先权日:2015-07-30
标 题 :Cyclic diarylboron derivatives as NLRP3 inflammasome inhibitors
发明人：BROUGH DAVID; ALLAN STUART MCRAE; FREEMAN SALLY; BALDWIN ALEX GEORGE
权利人:UNIV MANCHESTER
摘要:Inhibitor compounds are disclosed. The compounds are effective in the treatment of diseases or conditions in which interleukin 1 β activity is implicated. Methods of synthesis of the compounds, as well as pharmaceutical compositions comprising the compounds are also disclosed.

专利号:US-2002002286-A1
优先权日:2000-02-09
标 题:Solid-phase process for making indole compounds
发明人：KETCHA DANIEL MICHAEL; WILSON LAWRENCE JOSEPH
摘要:The subject invention involves a solid-phase process for the synthesis of indole compounds comprising the steps: n (a) treating an amino resin with diketene to provide a resin-bound acetoacetamide; n (b) treating the product from Step (a) with a primary amine in the presence of a dehydrating agent to provide a resin-bound enaminone; n (c) treating the product from Step (b) with a 1,4-benzoquinone, and releasing the resulting indole product from the resin.

专利号:US-6388093-B1
优先权日:2001-01-05
标 题:Syntheses for preparing 1,4-diketopyrrolo [3,4-c]pyrroles
发明人：CHAMBERLAIN TERRENCE R; THORNLEY CRAIG
权利人:SUN CHEMICAL CORP
摘要:A synthesis for preparing asymmetrical 1,4-diketopyrrolo[3,4-c]pyrroles involving: (a) reacting a β-ketoamide with a strong base; (b) halogenating the same or a different β-ketoamide; (c) reacting the reaction products of step (a) and (b) to form a succinamide; and (d) heating the succinamide in the presence of a Lewis Acid. Symmetrical 1,4-diketopyrrolo [3,4-c]pyrroles are synthesized by oxidatively dimerizing the reaction product of step (b) to form a succinamide; and heating the succinamide in the presence of a Lewis Acid.

专利号:US-2004215010-A1
优先权日:2000-06-13
标 题 :Universal solid supports for solid phase oligosynthesis and methods for their preparation and use
发明人：KUMAREV VIKTOR
权利人:KUMAREV VIKTOR
摘要:This invention pertains to solid-phase oligosynthesis, and more particularly to universal solid supports for solid-phase oligonucleotide synthesis, methods for their preparation, and methods for their use. One aspect of the invention pertains to a method for the preparation of a universal solid support suitable for use in solid-phase oligosynthesis, which method comprises the steps of: (a) reacting a pendant functional group (e.g., —NH2) of a solid support (e.g., CPG) with a linker reagent (e g., oxalyl chloride), thereby forming a pendant linker group (e.g., —C(â•?O)Cl); (b) removing at least a portion of excess unreacted linker reagent by evaporation (e.g., using a rotavapor apparatus); and, (c) reacting said pendant linker group with a cyclic reagent (e.g., protected inosine), thereby forming a pendant cyclic group.

专利号:CN-108863834-B
优先权日:2018-08-13
标题:Novel synthesis method of 2-fluoro-1, 3-dicarbonyl compound