CAS: 25024-53-7; Boc-His(Dnp)-Oh

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1260247-63-9 63013-46-7 83999-94-4

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CAS号52434-75-0 LHRH (1-5) (FRE... | CAS号77124-58-4 LHRH (1-4) (FRE...

专利信息

专利号:US-2007179279-A1
优先权日:2005-12-30
标题:Methods for the synthesis of arginine-containing peptides
发明人：CHEN LIN; ROBERTS CHRISTOPHER R
权利人:CHEN LIN; ROBERTS CHRISTOPHER R
摘要:Methods for the synthesis of arginine-containing peptides are provided. The methods include a step that minimizes contact of side chain protected arginine with base prior to the coupling step.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5175254-A
优先权日:1988-09-24
标题:Solid phase peptide synthesis using a polyacrylic support in aqueous solution
发明人：CALAS BERNARD; MERY JEAN; NAHARISOA HANITRA; FOLLET MICHEL
权利人:EXPANSIA SA
摘要:This invention relates to solid phase peptide synthesis. n Solid phase peptide synthesis is accomplished on polyacrylic resins (such as those described in EP 0 079 812 and EP 0 081 408 which correspond to U.S. Pat. Nos. 4,436,874 and 4,439,545 respectively) by a method which includes in the coupling protocol steps of washing the resin in water and/or aqueous solution(s).

专利号:EP-1968995-A1
优先权日:2005-12-30
标 题:Methods for the synthesis of arginine-containing peptides

专利号:US-4609643-A
优先权日:1980-08-06
标 题:Renin inhibitors, treatments and dipeptide synthesis
发明人：SZELKE MICHAEL; JONES DAVID M; HALLETT ALLAN
权利人:HAESSLE AB
摘要:Preparation of renin inhibitors based on the structure of natural renin substrate at residues 6 to 13 from the amino terminal thereof, the inhibitors being polypeptide analogues having in particular an isosteric non-peptide link corresponding to the 10, 11 peptide link of the substrate, and preparation of dipeptide analogues.

专利号:WO-2023196765-A1
优先权日:2022-04-04
标题 :Process for preparing a glp-1/glucagon dual agonist
发明人：KOPACH MICHAEL EUGENE; MURZINSKI EMILY SUZANNE
权利人:LILLY CO ELI
摘要:Disclosed herein are intermediate preparations for the manufacture of glucagon and GLP-1 dual agonist compounds or pharmaceutically acceptable salts thereof. Also disclosed herein are processes for the manufacture of glucagon and GLP-1 dual agonist compounds by coupling two to four intermediate preparations via hybrid solid liquid phase synthesis.