CAS: 27060-75-9; 1-Bromo-4-Methoxy-2-Methylbenzene

上下游产品

4-溴-3-甲基苯酚 4-Bromo-3-Methylphenol 14472-14-1
2,4-二溴-5-甲氧基甲苯 2,4-Dibromo-5-Methylanisole 5456-94-0
间甲基苯甲醚 1-Methoxy-3-Methyl-Benzene 100-84-5

2-甲基-4-甲氧基苯胺置于硫酸,氢溴酸,Copper(I) Bromide,Sodium Nitrite体系中,化学反应生成2-溴-5-甲氧基甲苯
参考文献:在a环羟基化维生素d型化合物的研究中,碰撞诱导解离.
标题:在a环羟基化维生素d型化合物的研究中,碰撞诱导解离.
摘要:碰撞诱导解离(cid)通常用于与已知离子的cid光谱进行比较,从而确定离子的结构.后者是根据离子化学的基本原理,由明智选择的化合物产生的.我们在这里报告了使用这种方法确定维生素d的a环羟基的位置.虽然本质上不是芳香族化合物,但维生素d的质谱在m / Z 118处增加为芳香族甲基苯乙烯基阳离子.因此,维生素d的环上羟基化代谢物将在m / Z 118处将额外的oh基团并入离子,从而将其转移至m / Z 134.然后,可以通过将其m / Z 134片段的cid谱图与从合成的真实化合物生成的四种可能的(羟甲基)苯乙烯基阳离子的cid谱图进行比较,来确定代谢产物上额外oh基团的取代位置.由于它们的聚合倾向,这些阳离子是通过相应的(羟苯基)乙醇的麦克拉菲重排反应原位生成的.为了最佳区分异构体离子,必须制备维生素d的全甲基化衍生物.使用1,25-二羟基维生素d3作为测试化合物验证了该假设的有效性.该方法
Doi:10.1021/ac00032A004

专利信息

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-7056348-B2
优先权日:2001-04-19
标题:5-aryl-1,3,3-trimethyl-2-methylene-indoline derivatives and salts thereof, methods for the production and use of said compounds for the temporary coloration of fibers
发明人：SAUTER GUIDO; BRAUN HANS-JUERGEN; REICHLIN NADIA
权利人:WELLA AG
摘要:A method for the synthesis of 5-aryl-1,3,3,-trimethyl-2-methylene-indoline derivatives of Formula (I) or its salts of Formula (Ia) wherein 1 mole of a 5-aryl-2,3,3-trimethyl-3H-indole derivative of Formula (VII) is reacted for 1 to 44 hours at a temperature of 20° to 180° C. in an apolar, aprotic or polar, protic or polar aprotic solvent with 1 to 50 moles of a compound of Formula R1-A; new compounds of Formulas (I)/(Ia) and (V), obtainable by this method as well as an agent containing at least one compound of Formula (I)/(Ia) and a carbonyl/imine compound for dyeing keratinic fibers and a method for temporarily dyeing keratin fibers, for which the keratin fiber is dyed with the aforementioned agent and the dyeing, so obtained, is removed again at any later time by a sulfite preparation.

专利号:US-6107508-A
优先权日:1998-04-03
标 题 :Convergent synthesis of α-aryl-β-ketonitriles
发明人：ZHOU JIACHENG; OH LYNETTE MAY; MA PHILIP
权利人:DU PONT PHARM CO
摘要:The present invention relates to processes for the production of alpha -aryl- beta -ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.

专利号:US-7112679-B2
优先权日:1998-04-03
标题:Convergent synthesis of α-aryl-β-ketonitriles
发明人：ZHOU JIACHENG; OH LYNETTE MAY; MA PHILIP
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to processes for the production of α-aryl-β-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.

专利号:US-2004171829-A1
优先权日:1998-04-03
标 题:Convergent synthesis of alpha-aryl-beta-ketonitriles

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues