CAS: 29823-21-0; Ethyl 8-Bromooctanoate

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17696-11-6 50816-19-8 29823-18-5

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CAS号64-17-5 乙醇 | CAS号17696-11-6 8-溴辛酸 | CAS号67-56-1 甲醇 | CAS号1593-55-1 壬二酸单乙基酯 | CAS号140-88-5 丙烯酸乙酯 | CAS号123-99-9 壬二酸 | CAS号624-17-9 壬二酸二乙酯 | CAS号4117-09-3 7-溴-1-庚烯 | CAS号629-03-8 1,6-二溴己烷 | CAS号17696-11-6 8-溴辛酸 | CAS号313486-62-3 8-(4-cyanopheno... | CAS号338995-26-9 ethyl 8-(4-phen... | CAS号73674-09-6 8-溴辛酰氯 | CAS号85318-87-2 ethyl 11-oxound... | CAS号56703-12-9 ethyl 8-iodo°Ct... | CAS号38232-01-8 三十一烷酸 | CAS号38232-03-0 tritriacontanoi... | CAS号519186-18-6 8-(4-phenylmeth...

壬二酸置于对甲苯磺酸,Silver Nitrate,Potassium Hydroxide,Sodium Hydroxide体系中,用 乙醇,水,甲苯 用作溶剂,化学反应 10.83H,反应生成8-溴辛酸乙酯
参考文献:Synthesis,Antiproliferation,And Docking Studies Of N-Phenyl-Lipoamide And 8-Mercapto-N-Phenyloctanamide Derivatives: Effects Of C6 Position Thiol Moiety
标题:Synthesis,Antiproliferation,And Docking Studies Of N-Phenyl-Lipoamide And 8-Mercapto-N-Phenyloctanamide Derivatives: Effects Of C6 Position Thiol Moiety
摘要:Some N-Phenyl Lipoamide And 8-Mercapto-N-Phenyloctanamide Derivatives Were Synthesized And Their In Vitro Antiproliferative Activity Was Evaluated. The Experimental Results Indicated That 8-Mercapto-N-Phenyloctanamides Might Be Good Histone Deacetylase Inhibitors Rather Than N-Phenyl Lipoamides,Who Had Thiol Moiety At C6 Position. To Verify The Antiproliferation Data On Structural Basis,In Silico Docking Studies Of The Representative Compounds Into The Crystal Structure Of Histone Deacetylase-Like Protein Using Autodock 4.0 Program Were Performed. Furthermore,Sulfur Acetylated 8-Mercapto-N-Phenyloctanamide Improved Its In Vitro Antiproliferative Activity,Probably Due To The Increasing Of Its Cell Membrane Permeability. While The Identification Of Enzymatic Target Of N-Phenyl Lipoamides With Dithiolane Is Still Ongoing.
Doi:10.1007/s00044-011-9879-7

专利信息

专利号:US-2025162968-A1
优先权日:2022-02-02
标 题 :Method for Producing Ionizable Lipids or Intermediates for the Synthesis of Such Lipids
发明人：ATMURI N D PRASAD; ARNOLD DEAGLAN; SAADATI FARIBA; KUREK DANIEL; KULKARNI JAYESH; WITZIGMANN DOMINIK; CIUFOLINI MARCO A
权利人:NANOVATION THERAPEUTICS INC
摘要:The present disclosure provides a method for producing one or more intermediates for the synthesis of one or more ionizable lipids, the method comprising: (i) producing a beta-ketoacid by reacting a cyclic ester, a terminal hydroxyester or a derivative thereof, a dicarboxylic acid half ester, or an acid chloride derivative of the dicarboxylic acid half ester, in a condensation reaction, thereby producing the beta-ketoacid or a beta-ketoester that is hydrolyzed to produce the beta-ketoacid; and (ii) decarboxylating the beta-ketoacid, thereby producing the one or more intermediates, wherein the one or more intermediates have a structure that may be defined by Formula A. Further provided is a method for producing ionizable lipid from the intermediate comprising adding an ionizable head group moiety to (a) a ketone group of one or more intermediates having the structure that may be defined by Formula A; or (b) a corresponding alcohol of the intermediate.

专利号:US-7038072-B2
优先权日:2002-07-24
标 题 :Process for monoalkylation of C-H acidic methylene groups
发明人：BODMANN KERSTIN; MEYER OLIVER; KAUFHOLD MANFRED; FIEKER JUERGEN; PAULCZYNSKI RENATE
权利人:DEGUSSA
摘要:The present invention is directed to a process for the synthesis of monoalkylated C—H acidic methylene group-containing compounds, such as malonic esters, and malonic ester nitriles.

专利号:US-4539410-A
优先权日:1982-09-30
标题:N-Substituted-2-(1-imidazolyl)indoles
发明人：RENFROE HARRIS B
权利人:CIBA GEIGY CORP
摘要:Various 1-carboxylic acid substituted-2-(1-imidazolyl)indoles and functional derivatives thereof are highly specific thromboxane synthetase inhibitors. Synthesis of, pharmaceutical compositions thereof, methods of treatment utilizing such compounds and intermediates for their synthesis are included.

专利号:WO-2023147657-A1
优先权日:2022-02-02
标题 :Method for producing ionizable lipids or intermediates for the synthesis of such lipids

专利号:EP-4472941-A1
优先权日:2022-02-02
标 题 :Method for producing ionizable lipids or intermediates for the synthesis of such lipids

专利号:RU-2404158-C2
优先权日:2004-12-16
标题 :Method for synthesis of n-substituted salicylamides