专利号:US-5861532-A 优先权日:1997-03-04 标 题:Solid-phase synthesis of N-alkyl amides 发明人:BROWN EDWARD G; NUSS JOHN M 权利人:CHIRON CORP 摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.
专利号:US-10647655-B2 优先权日:2016-09-02 标题:Method for the synthesis of permethrin 发明人:PULLAGURLA MANIK REDDY; NANDA KUMAR MECHERIL VALSAN; VELIGETLA MADHUSUDHANA RAO; RANGISETTY JAGADEESH BABU 权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD 摘要:An improved method for the synthesis of substantially pure Permethrin having purity greater than 99.5% by Gas Chromatography provided. The embodiments also relates to a purification process of Permethrin by recrystallization from methanol-water mixture.
专利号:WO-9216499-A1 优先权日:1991-03-13 标 题 :General synthesis method by photochemical process of cyclopropanic components present in natural pyrethrines and in synthetic pyrethroids and their 1-aza-1,4,6 trianic precursors 发明人:ARMESTO VILAS DIEGO; GOMEZ GALLEGO MAR; HORSPOOL WILLIAM M; BERMEJO TORRES FERNANDO 权利人:UNIV MADRID COMPLUTENSE 摘要:The present invention relates to the synthesis of 2,2-dimethyl-3-(vinyl-2,2-bi-substituted) cyclopropanocarboxylic acids. Said acids are present in the majority of natural pyrethrines and in synthetic pyrethroids. These acids are obtained by the transposition reaction aza-di-Ï€-methane of a 1-aza-1,4,6-trianic system for which there are disclosed three different synthetic processes. Thereby, precursors are available to obtain pyrethrines and pyrethroids, obtained by a direct and simple process with a high yield.
专利号:US-5443978-A 优先权日:1993-03-11 标 题 :Chrysanthemyl diphosphate synthase, corresponding genes and use in pyrethrin synthesis 发明人:ELLENBERGER SUZANNE R; PEISER GALEN D; BELL RUSSELL N; HUSSEY JR CHARLES E; SHATTUCK-EIDENS DONNA M; SWEDLUND BRADLEY D 权利人:AGRIDYNE TECH INC 摘要:This invention provides a purified chrysanthemyl diphosphate synthase (CDS), a method for the purification of CDS from Chrysanthemum cinerariaefolium, and an amino acid sequence of the isolated CDS. Also provided is a cDNA encoding the CDS, a nucleotide sequence of the CDS gene, and a derived amino acid sequence of the encoded CDS protein. The CDS gene is useful in the enzymatic production of the natural stereospecific configuration of chrysanthemyl derivatives which are useful for the synthesis of pyrethrins, pyrethroids, derivatives thereof, as well as other classes of metabolites.
专利号:WO-0026190-A1 优先权日:1998-10-30 标 题:Chiral amino alcohol derivatives of pyridine, a method for the manufacture thereof and their use as catalysts 发明人:NEVALAINEN VESA; SYLVESTRE DEGNI 权利人:NESTE CHEMICALS OY; NEVALAINEN VESA; SYLVESTRE DEGNI 摘要:The invention relates to chiral amino alcohol derivatives of pyridine, which compounds are useful as catalysts in combination with organic zinc compounds for asymmetric induction reactions and more particularly for enantioselective synthesis of optically active alcohols from aldehydes. The invention also relates to a process for the preparation of the said amino alcohol derivatives of pyridine and to a method for the manufacture of optically active alcohols from aldehydes in the presence of organic zinc compounds and amino alcohol derivatives of pyridine.
专利号:US-4288386-A 优先权日:1979-05-18 标 题:Ullmann reaction for the synthesis of diaryl ethers 发明人:SOULA GERARD; LINGUENHELD LOUIS 权利人:RHONE POULENC IND 摘要:The Ullman reaction for the preparation of diaryl ethers by coupling aryl halides with metal phenolates is conducted in the presence of at least one tertiary amine sequestering agent having the formula: n n N--CHR.sub.1 --CHR.sub.2 --O--CHR.sub.3 --CHR.sub.4 --O--.sub.n R.sub.5 n n ] 3
[参考文献]: Master He, Et Al. Synthesis Of Low Molecular Weight Compounds With Complement Inhibition Activity. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1249-51. [参考文献]: Alexia Chandor-Proust, Et Al. The Central Role Of Mosquito Cytochrome P450 Cyp6Zs In Insecticide Detoxification Revealed By Functional Expression And Structural Modelling. Biochem J. 2013 Oct 1;455(1):75-85. [参考文献]: Anders Lennartson, Et Al. Spontaneous Generation Of Chirality In Simple Diaryl Ethers. Chirality. 2015 Jul;27(7):425-9. [参考文献]: Choonshik Shin, Et Al. Identification And Structure Elucidation Of A P-Phenoxybenzaldehyde In Bamboo Shoots By Hplc-Esi/ms/ms And Nmr. J Agric Food Chem. 2011 Nov 9;59(21):11579-84. [参考文献]: Dhivya Vadhana, Et Al. Perturbation Of Rat Heart Plasma Membrane Fluidity Due To Metabolites Of Permethrin Insecticide. Cardiovasc Toxicol. 2011 Sep;11(3):226-34.
合成参考文献
摘要:Li, W.; Liu, X. H.; Feng, X. M., Science of Synthesis Knowledge Updates, (2021) 1, 5. 摘要:Braverman, S.; Cherkinsky, M., Science of Synthesis Knowledge Updates, (2014) 3, 201. 摘要:Wang, W. T.; Lin, L. L.; Liu, X. H.; Feng, X. M., Science of Synthesis Knowledge Updates, (2011) 4, 378. 摘要:Łaźny, R.; Nodzewska, A., Science of Synthesis Knowledge Updates, (2012) 3, 476. 摘要:Yliniemelä-Sipari, S. M.; Piisola, A.; Pihko, P. M., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 44.