CAS: 50850-93-6; Ethyl 2-Aminobenzo[d]Thiazole-6-Carboxylate

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苯佐卡因置于溴体系中,用 溶剂黄146 作为反应溶剂,以31%的收率获得产物2-氨基苯并噻唑-6-羧酸乙酯
参考文献:Fibrosis Inhibitor
标题:Fibrosis Inhibitor
摘要:药物作为器官或组织的纤维化抑制剂而有用,包括具有以下式(i)的化合物: 其中环z是可选择取代的吡咯环等;w2是-Co-,-So2-,可选择取代的c1-C4烷基等;ar2是可选择取代的芳基等;w1和ar1表示如下(1)和(2): (1)w1是可选择取代的c1-C4烷基等;ar1是可选择取代的具有1至4个氮原子作为环形成原子的双环杂芳基: (2)w1是可选择取代的c2-C5烷基,可选择取代的c2-C5烯基等;以及 Ar1是芳基或单环杂芳基,其在相对于w1的结合位置的邻位或间位处被羧基,烷氧羰基等取代,或其药学上可接受的盐.

专利信息

专利号:US-4118384-A
优先权日:1976-02-21
标题 :Process for preparation of azo dyestuffs by coupling in presence of aromatic sulphonic acid-formaldehyde reaction product
发明人：MOLLS HANS-HEINZ; SCHIWY WILLY; HORNLE REINHOLD; NEBELING REINHARD
权利人:BAYER AG
摘要:Dyestuff dispersions and dyestuff solutions free from salt or at least having a low salt content are obtained in that the diazotization is carried out with addition of free dispersing agent acid to which, after the synthesis, either no basic agents are added or basic agents are added only up to a pH value of 3. The disclosed process gives dyestuff compositions of low salt content and results in readily dispersible dyestuffs when water insoluble dyestuffs are prepared and stable solutions when water soluble dyestuffs are prepared. The process is widely applicable and chemical constitution of the dyestuffs is conventional.