CAS: 61276-17-3; (2R,3R,4R,5R,6R)-6-(3,4-Dihydroxyphenethoxy)-5-Hydroxy-2-(Hydroxymethyl)-4-(((2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-3-Yl (E)-3-(3,4-Dihydroxyphenyl)Acrylate

该化合物是各种植物,特别是Verbascum 物种中自然产生的甘油化合物. 其主要优势在于抗氧化剂和抗炎特性,展示了强大的自由彻底清扫活动,以及皮肤和伤口愈合的潜在治疗用途,以及抗微生物和抗肿瘤活动.

结构式图片

上下游产品

CAS号253790-76-0 3,4-di(benzylox... | CAS号96826-11-8 Benzeneethanol,... | CAS号54429-62-8 3-[3,4-bis(phen... | CAS号39698-00-5 1,2,4,6-四-O-乙酰基... | CAS号253790-67-9 2,4,6-tri-O-ace... | CAS号253790-69-1 3,4-di(benzylox... | CAS号253790-72-6 3,4-di(benzylox... | CAS号253790-68-0 3,4-di(benzylox... | CAS号253790-71-5 3,4-di(benzylox... | CAS号10597-60-1 3,4-二羟基苯乙醇 | CAS号3843-74-1 咖啡酸甲酯 | CAS号61303-13-7 异麦角甾苷

合成工艺路线路线简述

    (E)-3-(3,4-Bis(Benzyloxy)Phenyl)Acrylic Acid置于palladium On Activated Charcoal 4-二甲氨基吡啶,Selenium(Iv) Oxide,1,4-环己二烯,三氟化硼乙醚,4-(Dimethylamino)Pyridine Hydrochloride,溶剂黄146,N,N'-二环己基碳二亚胺,甲胺体系中,用 1,4-二氧六环,甲醇,乙醇,二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 27.0H,反应生成 毛蕊花糖苷
    参考文献:Total Synthesis Of The Phenylpropanoid Glycoside,Acteoside
    标题:Total Synthesis Of The Phenylpropanoid Glycoside,Acteoside
    摘要:
    DOI:10.1021/jo9906983

    专利信息


    专利号:US-9943544-B2
    优先权日:2015-03-18
    标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancer
    发明人:BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH
    权利人:BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH
    摘要:The present invention is a process for bio synthesis of nano arsenic trioxide defined by its low toxicity, higher bio availability and nano particle size with the aid of buttermilk, goat urine, dolichos biflorous and other plant materials such as ginger, momordica charantia and musa paradisiaca . The invention is carried out in different steps involving purification of crude form of arsenic trioxide by boiling it with buttermilk, goat urine and extract of dolichos biflorous in subsequent steps, followed by the trituration of the bio purified arsenic trioxide with extracts of ginger and momordica charantia in subsequent steps and heating of the dry product obtained after trituration with musa paradisiaca resulting in the production of novel nano arsenic trioxide. The product is effective in the treatment of various diseases including different types of cancer in animals and humans. The product obtained through the process is less toxic with higher bio availability.

    专利号:WO-2025105947-A1
    优先权日:2023-11-15
    标 题 :Synthesis of polyols and polyesters by chemical degradation of industrial rubbers and natural rubbers for application in new polymer materials
    发明人:TREVIÑO QUINTANILLA CECILIA DANIELA; BURELO TORRES JOSÉ MANUEL
    权利人:INST TECNOLOGICO ESTUDIOS SUPERIORES MONTERREY
    摘要:The present invention relates to a process for synthesising and obtaining biobased hydroxyl-terminated telechelic oligomers, such as biobased hydroxyl-terminated polybutadiene, by means of a degradation reaction via metathesis of industrial rubbers and using fatty alcohols as chain transfer agents (CTA). In particular, the present invention relates to the synthesis and production of diols, polyols and polyesters based on a degradation reaction via metathesis between industrial rubbers or natural rubbers and essential oils, fatty acids, fatty alcohols and terpenes with R-OH and R-COO-R terminal groups, the chemical structure, molecular weight and properties of which can be controlled.

    专利号:US-2002165207-A1
    优先权日:2001-05-02
    标题 :Compositions and methods for the treatment of diabetic neuropathy
    发明人:ROSENBLOOM RICHARD
    摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

    专利号:EP-3741361-A1
    优先权日:2019-05-09
    标题 :Gastro-resistant food/pharmaceutical capsule for treatment of inflammatory bowel diseases
    发明人:BORNORONI CORRADO; DI RENZO LAURA; GALLESE WALTER; GIOVINAZZO CORRADO; ROVERSI FRANCESCO; SMERIGLIO ANTONELLA; TROMBETTA DOMENICO; SENECI ANTONIO
    权利人:P&P FARMA S R L
    摘要:A gastro-resistant food/pharmaceutical capsule for treatment of inflammatory bowel diseases, provided with a gastro-resistant film coating, said coating Including: n- a gastro-resistant polymer film, n- a plasticizing means, n- a lubricating means, and n- an opacifying means, nwherein said capsule comprises: n- hydroxytyrosol, obtained from olive extract and/or olive leaves and/or chemical synthesis: between 2.5 and 20 mg/capsule; n- DL-alpha-tocopheryl acetate: between 3.75 and 30 mg/capsule; n- L-Menthol: between 25 and 300 mg/capsule, nsaid components being carried in olive and/or extra virgin olive oil.

    专利号:US-2025231101-A1
    优先权日:2024-01-11
    标 题 :Validation of natural matrices for therapeutic use on humans, animals and plants on bio-physical bases as an alternative to validation through chemically definable substances derived from said matrices by isolation and/or synthesis processes and also as an alternative to products comprising natural matrices validated on the basis of their traditional use
    发明人:MERCATI VALENTINO; LUCCI JACOPO
    权利人:BIOS THERAPY PHYSIOLOGICAL SYSTEMS FOR HEALTH S P A
    摘要:The present invention relates to a new method for assessing acceptability ranges or cut-offs for the compliance validation of batches of products comprising or consisting of one or more natural matrix, wherein said products have an ascertained therapeutic or beneficial effect. The invention also relates to a new process for the compliance validation of one or more batches of said products.

    专利号:US-2016271177-A1
    优先权日:2015-03-18
    标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancer
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    主要参考文献


    1: D'Antuono I, Bruno A, Linsalata V, Minervini F, Garbetta A, Tufariello M, Mita G, Logrieco AF, Bleve G, Cardinali A. Fermented Apulian table olives: Effect of selected microbial starters on polyphenols composition, antioxidant activities and bioaccessibility. Food Chem. 2018 May 15;248:137-145. doi: 10.1016/j.foodchem.2017.12.032. Epub 2017 Dec 11. doi: 10.3389/fnut.2017.00063. eCollection 2017.
    3: Medjkouh L, Tamendjari A, Alves RC, Laribi R, Oliveira MBPP. Phenolic profiles of eight olive cultivars from Algeria: effect of Bactrocera oleae attack. Food Funct. 2018 Jan 4. doi: 10.1039/c7fo01654a. [Epub ahead of print] doi: 10.2527/jas2017.1603. doi: 10.19540/j.cnki.cjcmm.20170905.004. Chinese. doi: 10.1016/j.phytochem.2017.11.012. Epub 2017 Dec 22. doi: 10.1016/j.fct.2017.11.060. Epub 2017 Dec 5. doi: 10.1186/s12906-017-2005-8.
    9: Zou P, Song Y, Lei W, Li J, Tu P, Jiang Y. Application of (1)H NMR-based metabolomics for discrimination of different parts and development of a new processing workflow for Cistanche deserticola. Acta Pharm Sin B. 2017 Nov;7(6):647-656. doi: 10.1016/j.apsb.2017.07.003. Epub 2017 Aug 26.

    合成参考文献


    参考文献:10.1055/s-2001-16473
    摘要:He ZD, Huang Y, Yao X, Lau CW, Law WI, Chen ZY. Purification of phenylethanoids from Brandisia hancei and the antiproliferative effects on aortic smooth muscle. Planta Med. 2001 Aug;67(6):520–2. doi: 10.1055/s-2001-16473.
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