专利号:US-7109377-B2 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products 发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R 权利人:HARVARD COLLEGE 摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
专利号:US-6245937-B1 优先权日:1996-11-29 标题 :Liquid phase parallel synthesis of chemical libraries 发明人:CHENG SOAN; SAUNDERS JOHN 权利人:DUPONT PHARMACEUTICALS RES LAB 摘要:This invention features methods of biphasic synthesis for synthesizing combinatorial libraries and combinatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this invention.
专利号:US-6413957-B1 优先权日:1998-04-21 标题:Methods of inhibiting cell proliferation using indeno [1,2-c]pyrazol-4-ones 发明人:NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W 权利人:BRISTOL MYERS SUIBB PHARMA COM 摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
专利号:US-2024239805-A1 优先权日:2022-12-16 标 题:Aza-yang cyclization-buchner aromatic ring expansion: collective synthesis of cycloheptatriene-containing azetidine lactones 发明人:SINGH MANVENDRA PAL; BOSKOVIC ZARKO; GASKINS BRYCE 权利人:UNIV KANSAS 摘要:The present disclosure is directed to a compound of Formula I, Formula II, Formula III, Formula IV, or Formula Vor a pharmaceutically acceptable salt and/or solvate thereof.
专利号:US-4388310-A 优先权日:1982-03-01 标 题:6-Amido-2-S-oxides of substituted 2-organothio-pen-2-em-3-carboxylic acids 发明人:CHRISTENSEN BURTON G; DININNO FRANK P; MUTHARD DAVID A; RATCLIFFE RONALD W 权利人:MERCK & CO INC 摘要:Disclosed are 6-amido-2-S-oxides of substituted 2-organothio-pen-2-em-3-carboxylic acids (I) which are useful as antibiotics and as intermediates in the synthesis of substituted pen-2-em-3-carboxylic acids: I wherein: R1 is H or acyl; R2 is hydrogen or methoxyl; R3 is alkyl having from 1-6 carbon atoms; phenylalkyl having 7-12 carbon atoms; and cycloalkyl having 3-6 carbon atoms; and R4 is hydrogen, a removable protecting group or a pharmaceutically acceptable salt or ester moiety.
专利号:WO-2007007735-A1 优先权日:2005-07-12 标 题 :Synthesis of organic conductive polymerizable material onto metal oxide surface through light irradiation 发明人:TACHIBANA YASUHIRO 权利人:UNIV OSAKA; KANSAI TECH LICENSING ORG CO; TACHIBANA YASUHIRO 摘要:Disclosed is a composite material having a nanostructure containing metal oxide fine particles and an organic conductive polymerizable material. In this composite material, the metal oxide fine particles are joined with one another and the organic conductive polymerizable material is contained in the spaces between the fine particles. In this connection, the organic conductive polymerizable material is a copolymer which is composed of a polythiophene derivative, a thiophene or a derivative thereof and pyrrole, aniline, fluorene, furan or a derivative thereof. Also disclosed is a method for producing such a composite material. This composite material is useful for display elements such as electronic paper.
[参考文献]: Ambareesh Kumar Singh, Et Al. Qcm Sensing Of Melphalan Via Electropolymerized Molecularly Imprinted Polythiophene Films. Biosens Bioelectron. 2015 Dec 15:74:711-7. [参考文献]: Maria M Pérez-Madrigal, Et Al. Thermoplastic Polyurethane:Polythiophene Nanomembranes For Biomedical And Biotechnological Applications. Acs Appl Mater Interfaces. 2014 Jun 25;6(12):9719-32. [参考文献]: Seyda Korkut, Et Al. Design Of A Mediated Enzymatic Fuel Cell To Generate Power From Renewable Fuel Sources. Environ Technol. 2016;37(2):163-71.
合成参考文献
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