CAS: 6964-21-2; 3-Thiopheneacetic Acid

该化合物是一种有机化合物,其特点是其硫苯环结构,即五人组成的含有硫磺的芳香环;该化合物具有三处硫苯环的碳盒酸功能组(-COOH),它影响其化学反应和特性;它通常是室内温度一种白色到浅黄色的固体,由于存在碳盒酸组,在水和酒精等极溶溶剂中溶解;复合物的酸性行为,能够将质子捐献溶液,并能够参与各种化学反应,包括酯化和恐吓;此外,3-硫酸可能展示生物活动,使其在制药研究中引起兴趣;它的独特结构允许有机合成和材料科学的潜在应用,特别是在发展功能化聚合物和化学协调性离子方面.与许多有机化合物一样,处理应谨慎进行,考虑到安全数据和与使用有关的潜在危险.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号71637-34-8 3-噻吩甲醇 | CAS号201230-82-2 carbon monoxide | CAS号34846-44-1 3-溴甲基噻吩 | CAS号13781-66-3 2-(thiophen-3-y... | CAS号143-33-9 氰化钠 | CAS号41507-35-1 3-噻吩甲酰氯 | CAS号88-13-1 3-噻吩甲酸 | CAS号37784-63-7 3-噻吩乙酸乙酯 | CAS号53064-74-7 propan-2-yl 2-t... | CAS号37784-63-7 3-噻吩乙酸乙酯 | CAS号51460-47-0 3-噻吩甲酰胺 | CAS号188718-23-2 2-(2-chlorothio... | CAS号58414-52-1 噻吩-3-乙酸甲酯 | CAS号616-44-4 3-甲基噻吩 | CAS号13781-67-4 2-(3-噻吩基)乙醇 | CAS号13781-65-2 噻吩-3-基-乙酰氯 | CAS号70158-52-0 DIMETHYL 3-THIE... | CAS号77014-14-3 1-[(2,5-dibromo... | CAS号77626-88-1 Ethanone,1-[1-[...

合成工艺路线路线简述

    3-噻吩甲酰氯置于sodium Hydroxide,乙醚体系中,化学反应生成 3-噻吩乙酸
    参考文献:Otsuji Et Al.,Nippon Kagaku Zasshi,1959,Vol. 80,P. 1293,1295
    标题:Otsuji Et Al.,Nippon Kagaku Zasshi,1959,Vol. 80,P. 1293,1295

    海关参考信息

    专利信息


    专利号:US-7109377-B2
    优先权日:1996-10-16
    标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
    发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
    权利人:HARVARD COLLEGE
    摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

    专利号:US-6245937-B1
    优先权日:1996-11-29
    标题 :Liquid phase parallel synthesis of chemical libraries
    发明人:CHENG SOAN; SAUNDERS JOHN
    权利人:DUPONT PHARMACEUTICALS RES LAB
    摘要:This invention features methods of biphasic synthesis for synthesizing combinatorial libraries and combinatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this invention.

    专利号:US-6413957-B1
    优先权日:1998-04-21
    标题:Methods of inhibiting cell proliferation using indeno [1,2-c]pyrazol-4-ones
    发明人:NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W
    权利人:BRISTOL MYERS SUIBB PHARMA COM
    摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

    专利号:US-2024239805-A1
    优先权日:2022-12-16
    标 题:Aza-yang cyclization-buchner aromatic ring expansion: collective synthesis of cycloheptatriene-containing azetidine lactones
    发明人:SINGH MANVENDRA PAL; BOSKOVIC ZARKO; GASKINS BRYCE
    权利人:UNIV KANSAS
    摘要:The present disclosure is directed to a compound of Formula I, Formula II, Formula III, Formula IV, or Formula Vor a pharmaceutically acceptable salt and/or solvate thereof.

    专利号:US-4388310-A
    优先权日:1982-03-01
    标 题:6-Amido-2-S-oxides of substituted 2-organothio-pen-2-em-3-carboxylic acids
    发明人:CHRISTENSEN BURTON G; DININNO FRANK P; MUTHARD DAVID A; RATCLIFFE RONALD W
    权利人:MERCK & CO INC
    摘要:Disclosed are 6-amido-2-S-oxides of substituted 2-organothio-pen-2-em-3-carboxylic acids (I) which are useful as antibiotics and as intermediates in the synthesis of substituted pen-2-em-3-carboxylic acids: I wherein: R1 is H or acyl; R2 is hydrogen or methoxyl; R3 is alkyl having from 1-6 carbon atoms; phenylalkyl having 7-12 carbon atoms; and cycloalkyl having 3-6 carbon atoms; and R4 is hydrogen, a removable protecting group or a pharmaceutically acceptable salt or ester moiety.

    专利号:WO-2007007735-A1
    优先权日:2005-07-12
    标 题 :Synthesis of organic conductive polymerizable material onto metal oxide surface through light irradiation
    发明人:TACHIBANA YASUHIRO
    权利人:UNIV OSAKA; KANSAI TECH LICENSING ORG CO; TACHIBANA YASUHIRO
    摘要:Disclosed is a composite material having a nanostructure containing metal oxide fine particles and an organic conductive polymerizable material. In this composite material, the metal oxide fine particles are joined with one another and the organic conductive polymerizable material is contained in the spaces between the fine particles. In this connection, the organic conductive polymerizable material is a copolymer which is composed of a polythiophene derivative, a thiophene or a derivative thereof and pyrrole, aniline, fluorene, furan or a derivative thereof. Also disclosed is a method for producing such a composite material. This composite material is useful for display elements such as electronic paper.
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    主要参考文献

    [参考文献]: Ambareesh Kumar Singh, Et Al. Qcm Sensing Of Melphalan Via Electropolymerized Molecularly Imprinted Polythiophene Films. Biosens Bioelectron. 2015 Dec 15:74:711-7.
    [参考文献]: Maria M Pérez-Madrigal, Et Al. Thermoplastic Polyurethane:Polythiophene Nanomembranes For Biomedical And Biotechnological Applications. Acs Appl Mater Interfaces. 2014 Jun 25;6(12):9719-32.
    [参考文献]: Seyda Korkut, Et Al. Design Of A Mediated Enzymatic Fuel Cell To Generate Power From Renewable Fuel Sources. Environ Technol. 2016;37(2):163-71.

    合成参考文献


    摘要:Zhou, Q.-Q.; Wei, Y.; Lu, L.-Q.; Xiao, W.-J., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 195.
    摘要:Sawamura, M.; Shimizu, Y., Science of Synthesis: Knowledge Updates, (2024) 2, 230.
    摘要:Tang, R.-Y., Science of Synthesis: Knowledge Updates, (2024) 1, 388.
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