CAS: 113886-71-8; N-(1-((2R,3R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-Methoxytetrahydrofuran-2-yl)-2-Oxo-1,2-Dihydropyrimidin-4-yl)Acetamide

上下游产品

1-[6-methoxy-2,2-dimethyl-(3aR,5R,6R,6aR)-perhydrofuro-[2,3-d][1,3]dioxol-5-yl]-(1R)-ethane-1,2-diol N-(2-Oxo-1-trimethylsilanyl-1,2-dihydro-pyrimidin-4-yl)-acetamide N-[2-Oxo-1-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclo°Cten-2-yl)-1,2-dihydro-pyrimidin-4-yl]-acetamide acetic anhydrideDiisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

N-乙酰基-3',5'-O-[1,1,3,3-四(异丙基)-1,3-二硅氧烷二基]胞苷置于四丁基氟化铵,Silver(L) Oxide体系中,用 四氢呋喃,苯 用作溶剂,化学反应生成N-乙酰基-2'-O-甲基胞苷
参考文献:Ultrafast Cleavage And Deprotection Of Oligonucleotides Synthesis And Use Of Cacderivatives
标题:Ultrafast Cleavage And Deprotection Of Oligonucleotides Synthesis And Use Of Cacderivatives
摘要:We Have Investigated The Use Of Alkylamines As Fast Cleavage And Deprotection Reagents For The Solid Phase Synthesis Of Oligonucleotides And Found Methylamine/ammonium Hydroxide (Or Methylamine) As An Efficient Reagent. The Transamination Side Product Formed With The Commonly Used Dc(Bz) Has Been Eliminated By The Use Of Dc(Ac) Phosphoramidite. This System Has Successfully Been Used In The Synthesis Of Oligonucleotides And Oligonucleoside Phosphorothioates. Dmt Dc(Ac) Hydrogen Phosphonate And Dmt Ribo C-Ac-2'-Ome Phosphoramidite Also Have Been Prepared And Used In The Synthesis Of Oligonucleotides.
Doi:10.1080/07328319708006236

专利信息

专利号:EP-1108724-B1
优先权日:1996-01-16
标题 :Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
发明人：WINCOTT FRANCINE; BEIGELMANN LEONID; MATULIC-ADAMIC JASENKA; USMAN NASSIM; HAEBERLI PETER; KARPEISKY ALEXANDER; SWEEDLER DAVID; JARVIS THALE; DIRENZO ANTHONY
权利人:SIRNA THERAPEUTICS INC
摘要:This invention relates to chemical synthesis of 2'-O-methyl, 3'-O-methyl and 5'-O-methyl nucleosides, incorporation of novel chemical modifications in enzymatic nucleic acid molecules and improved methods for the synthesis of enzymatic nucleic acid molecules.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-2014378538-A1
优先权日:2011-12-14
标 题:Methods of responding to a biothreat
发明人：BANCEL STEPHANE
权利人:MODERMA THERAPEUTICS INC
摘要:The present disclosure provides for devices, in particular mobile devices, which may be used in the synthesis of modified nucleic acid molecules, in particular modified mRNA molecules. The device for making the modified nucleosides, modified nucleotides and modified nucleic acids (e.g., mRNA) disclosed herein may be mobile devices comprising at least one sample block for insertion of one or more sample vessels, a device base with electronic control units for the sample block, a voltage supply, and one or more reagent(s) for the synthesis of at least one nucleic acid.

专利号:US-9790531-B2
优先权日:2012-08-14
标 题 :Enzymes and polymerases for the synthesis of RNA
发明人：WANG YUXUN; RAMAKRISHNAN DIVAKAR; DE FOUGEROLLES ANTONIN; WHORISKEY SUSAN
权利人:MODERNATX INC
摘要:The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.

专利号:US-2025207163-A1
优先权日:2022-03-25
标 题:Methods and apparatus for synthesizing nucleic acids
发明人：HOPKINS PATRYCJA A; SHAHSAVARI SHAHIEN; BEGOYAN VAGARSHAK; NJUMA OLIVE J; DEBENHAM HOLLY S; EFCAVITCH J WILLIAM; ALBIZATI KIM F
权利人:MOLECULAR ASSEMBLIES INC
摘要:Methods for the synthesis of polynucleotides using polymerases nucleotide analogs with labile terminator groups that allow stepwise addition of nucleotides are described. These nucleotide analogs may have a modification on 3′, 2′, or 3′-2′-bridged hydroxyl groups or on nucleobase moieties and can be used in the synthesis of natural or modified polynucleotides suitable for use in biological systems. The labile terminator groups are removed under mild conditions or by enzymes. They are accepted as substrates by polymerases. The synthesis may be carried out on a surface.

专利号:WO-2025101943-A1
优先权日:2023-11-10
标 题:Nucleic acid-guided dna synthesis
发明人：STERNBERG SAMUEL HENRY; TANG STEPHEN; ZHANG DENNIS JAMES; WIEGAND TANNER; THOMAS GEORGE JERRIN; LAMPE GEORGE DAVIS; KANG SHANNON
权利人:UNIV COLUMBIA
摘要:The present disclosure provides systems, compositions, methods, and kits, for guided DNA synthesis and genome engineering. Particularly, the present disclosure provides systems, compositions, methods, and kits comprising a defense-associated reverse transcriptase (DRT), or a nucleic acid encoding thereof, and an engineered target nucleic acid comprising one or more sequence of interest, or a nucleic acid encoding thereof.