CAS: 129101-54-8; (S)-3-(1-(Dimethylamino)Ethyl)Phenyl Ethyl(Methyl)Carbamate (2R,3R)-2,3-Dihydroxysuccinate

L-酒石酸置于sodium Hydroxide体系中,用 水,丙酮 用作溶剂,化学反应 1.5H,以84%的收率获得酒石酸卡巴拉汀
参考文献:Wo2006/68386
标题:Wo2006/68386

专利信息

专利号:US-2011104055-A1
优先权日:2002-05-31
标题:Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies
发明人：SNOW ALAN; WEIGELE MANFRED; LARSEN LESLEY; NGUYEN BETH; LAKE THOMAS; CASTILLO GERARDO; SANDERS VIRGINIA; WEAVERS REX T; LORIMER STEPHEN; LARSEN DAVID; COFFEN DAVID L; COFFEN CHARLOTTE
权利人:SNOW ALAN; WEIGELE MANFRED; LARSEN LESLEY; NGUYEN BETH; LAKE THOMAS; CASTILLO GERARDO; SANDERS VIRGINIA; WEAVERS REX T; LORIMER STEPHEN; LARSEN DAVID; COFFEN DAVID L; COFFEN CHARLOTTE
摘要:Compounds and their pharmaceutically acceptable salts, their synthesis and labeling, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided. Also provided is the use of the disclosed compounds as imaging agents and methods for in vivo imaging and detection of amyloid and synuclein.

专利号:US-2020095195-A1
优先权日:2018-09-26
标 题:Synthesis of novel intermediate(s) for preparing rivastigmine

专利号:US-10458995-B2
优先权日:2016-03-25
标 题 :Combinatorial synthesis and biomarker development
发明人：MOOLA MURALIDHAR REDDY
权利人:MOOLA MURALIDHAR REDDY
摘要:Provided herein are methods, kits, and compositions for use in the diagnosis and treatment of diseases. Peptoids recognized by Alzheimers disease specific antibodies are identified.

专利号:US-8916598-B2
优先权日:2003-05-30
标题 :Compounds, compositions, and methods for the treatment of β-amyloid diseases and synucleinopathies
发明人：ESPOSITO LUKE A; HUDSON F MICHAEL; LAKE THOMAS; CUMMINGS JOEL; WEIGELE MANFRED; SNOW ALAN D
权利人:ESPOSITO LUKE A; HUDSON F MICHAEL; LAKE THOMAS; CUMMINGS JOEL; WEIGELE MANFRED; SNOW ALAN D; PROTEOTECH INC
摘要:Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

专利号:GR-20120100008-A
优先权日:2010-12-09
标 题:A NEW ASymmetric Method for the Synthesis of Acid Trivial Rivastigmine, Crystalline Form Type II

专利号:GR-20120100007-A
优先权日:2010-12-09
标 题:A NEW ASymmetric Method for the Synthesis of Acid Trivial Rivastigmine, Crystalline Form Type II