Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于硫酸体系中,化学反应生成甲酚红 参考文献:Javery Et Al.,Journal Of Scientific And Industrial Research,1952,Vol. 11 B,P. 5,7 标题:Javery Et Al.,Journal Of Scientific And Industrial Research,1952,Vol. 11 B,P. 5,7
专利号:US-2002055171-A1 优先权日:1998-05-27 标题 :Preparation of biologically active 3-methyleneoxindole and definition of its application in stimulation of plant growth and tissue repair 发明人:TULI VIRENDA KUMAR 摘要:Identification of the true nature and metabolic action of 3 -methyleneoxindole (MO), a naturally occurring catabolite of the plant auxin, indole- 3 -acetic acid (IAA). Description of the two novel methods of synthesis of MO which produce the pure, biologically active auxin compound of MO. Discovery and description of the causes for the erroneous classification of MO as an inert compound with no auxin activity. These findings and methods of synthesis correct the ubiquitous theoretical errors which have driven scientific investigation and plant science research of plant auxins for nearly forty years. n Researchers have failed to observe the auxin activity of MO because of the use of standard but incorrect synthetic techniques which have consistently produced impure forms of 3 -bromooxindole- 3 -acetic acid ( 3 -Brox), the synthetic precursor of MO. In addition, the use of dimethylsulfooxide as a solvent for MO has been identified as a major source of contamination of MO during synthesis. n This invention describes two novel methods for synthesizing (MO). By using purified MO and avoiding the use of dimethylsulfoxide, it was found that the resulting MO product to be 100 to 1,00 fold more effective than IAA in promoting rooting in plant cuttings; supporting tissue differentiation and growth in stage I, stage II and stage III media used for the micropropagation of explants; promoting the formation of callus tissue over wounded plant parts; and, stimulating the production of interstitial tissue between scion and rootstock to increase the success rate for grafting. Therefore, this invention identifies MO as the dominant auxin in shoot acceleration, root development, wound sealing and scion acceptance. n Finally, the correct pathway from IAA to MO is presented.
专利号:US-6800477-B2 优先权日:2001-03-22 标 题:Stereoselective reduction of substituted acetophenone 发明人:PATEL RAMESH; GOSWAMI ANIMESH; CHU LINDA N; NANDURI VENKATA B; GOLDBERG STEVEN L; JOHNSTON ROBERT M; DONOVAN MARY JO; MIRFAKHRAE K DAVID 权利人:BRISTOL MYERS SQUIBB CO 摘要:The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of gamma-secretase useful in the treatment of Alzheimer's disease.
专利号:US-9976179-B2 优先权日:2011-03-30 标 题 :Nucleic acid sequencing technique using a pH-sensing agent 发明人:HAUSHALTER ROBERT C 权利人:PARALLEL SYNTHESIS TECH; PARALLEL SYNTHESIS TECH INC 摘要:The invention relates to a composition, method and apparatus for determining the sequence of a nucleic acid strand utilizing a pH-sensing agent.
专利号:US-9868767-B2 优先权日:2013-05-23 标 题:Chemical synthesis and screening of bicyclic peptide libraries 发明人:PEI DEHUA; UPADHYAYA PUNIT; LIAN WENLONG; TRINH THI 权利人:OHIO STATE INNOVATION FOUNDATION 摘要:Disclosed herein are bicyclic peptide compounds, compositions comprising same, methods for making same, and libraries comprising same. The disclosed compounds, in various aspects, are useful for treating a variety of disorders, including inflammatory disorders, autoimmune disorders, and disorders of uncontrolled cellular proliferation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
专利号:WO-2004024918-A1 优先权日:2002-09-12 标 题 :In vitro evolution of enzyme specificity 发明人:DALBY PAUL 权利人:UCL BIOMEDICA PLC; DALBY PAUL 摘要:This invention relates to the field of chemical synthesis and is particularly, though not exclusively, concerned with a method of producing active molecules, such as enzymes with desirable characteristics. In particular, the invention provides a method of producing new active molecules comprising at least 2 rounds of mutating a nucleic acid encoding an active molecule and selecting encoded active molecules which have activity against a substrate, wherein from round to round the substrate used differs from the previously used substrate by one or more minor differences.
专利号:WO-2024097977-A1 优先权日:2022-11-04 标题:Silk nanoparticle synthesis: tuning size, dispersity, and surface chemistry for drug delivery 发明人:SHAIDANI SAWNAZ; FALCUCCI THOMAS; FOSTER OLIVIA; SAHOO JUGAL KISHORE; HASTURK ONUR; KAPLAN DAVID L; JACOBUS CHARLOTTE S 权利人:TUFTS COLLEGE 摘要:Methods disclosed herein relate to generating silk nanoparticles with a low polydispersity index (PDI). Methods include adding a silk solution dropwise into a volatile solvent that is miscible with water, thereby forming a precipitate-bearing solution and applying shear forces to the precipitate-bearing solution for a length of time sufficient to achieve evaporation of at least 95% of the volatile solvent, thereby producing a population of silk fibroin nanoparticles in water having a polydispersity index (PDI) of 0.35 or less, including but not limited to, a PDI of 0.330 or less, 0.325 or less, 0.315 or less, 0.310 or less, 0.30 or less, 0.275 or less, 0.250 or less, 0.225 or less, or 0.200 or less. Parameters related to silk fibroin molecular weight, silk fibroin concentration, shear force application, and temperature may all be modified to achieve silk nanoparticles of a particular size exhibiting particular PDIs.
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合成参考文献
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