3-氯-6-甲基哒嗪置于ammonium Hydroxide,Copper(Ll) Sulfate Pentahydrate体系中,化学反应 40.0H,以37%的收率获得6-甲基-3-氨基哒嗪 参考文献:Compounds For Treating Spinal Muscular Atrophy 标题:Compounds For Treating Spinal Muscular Atrophy 摘要:本文提供了用于治疗脊髓性肌萎缩症的化合物,其组合物和使用方法.在一个具体实施例中,本文提供了一种形式的化合物,可用于调节从smn2基因转录的mrna中smn2的外显子7的包含.在另一个具体实施例中,本文提供了一种形式的化合物,可用于调节从smn1基因转录的mrna中smn1的外显子7的包含.在另一个实施例中,本文提供了一种形式的化合物,可用于调节从smn1和smn2基因分别转录的mrna中smn1和smn2的外显子7的包含.
专利信息
专利号:US-RE42890-E 优先权日:2003-05-23 标题 :Furazanobenzimidazoles 发明人:EBERLE MARTIN; BACHMANN FELIX; STREBEL ALESSANDRO; ROY SUBHO; SRIVASTAVA SUDHIR; SAHA GOUTAM 权利人:BASILEA PHARMACEUTICA AG 摘要:The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is oxygen, a carbonyl group, an oxime derivative of a carbonyl group or an α,β-unsaturated carbonyl group, and the substituents R 1 to R 6 have the meanings given in the specification, for use as medicaments, to novel compounds of formula (I), to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same
专利号:US-8372971-B2 优先权日:2004-08-25 标 题:Heterocyclic compounds and methods of use 发明人:WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA 权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA 摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.
专利号:US-11731956-B2 优先权日:2018-10-22 标 题:Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors