CAS: 5192-03-0; 1H-Indol-5-Amine

上下游产品

CAS号6146-52-7 5-硝基吲哚 | CAS号6405-28-3 N-苄基-3,3'-亚氨基二丙酸 | CAS号10075-50-0 5-溴吲哚 | CAS号166104-20-7 1-B°C-5-氨基吲哚 | CAS号87240-07-1 7-溴-5-硝基-1H-吲哚 | CAS号32692-19-6 5-硝基吲哚啉 | CAS号33632-27-8 1-乙酰基-5-硝基二氢吲哚 | CAS号87240-06-0 7-溴-5-硝基吲哚啉 | CAS号166104-19-4 5-硝基-1H-吲哚-1-甲酸叔丁酯 | CAS号496-15-1 二氢吲哚 | CAS号151273-51-7 5-(2,5-DIMETHYL... | CAS号6146-52-7 5-硝基吲哚 | CAS号135531-93-0 4-hydroxy-5-nit... | CAS号360045-07-4 5-amino-1-(3,5-... | CAS号100846-24-0 5-(三氟甲基)吲哚 | CAS号151273-37-9 5-(DIBENZYLAMIN... | CAS号184031-16-1 N-B°C-5-氨基吲哚 | CAS号184899-15-8 5-(哌嗪-1-基)-1H-吲哚 | CAS号65795-37-1 7H-吡咯并[3,2-f]喹唑... | CAS号81524-74-5 5-azidoindole

1-乙酰基-5-硝基二氢吲哚置于sodium Hydroxide,Aluminium-Nickel Alloy体系中,用 水 作为反应溶剂,化学反应 1.5H,以56%的收率获得产物5-氨基吲哚
参考文献:Indole Derivatives. 131. The Basicity Of 5-And 6-Aminoindoles
标题:Indole Derivatives. 131. The Basicity Of 5-And 6-Aminoindoles
摘要:
DOI:10.1007/bf00475595

专利信息

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-2024262834-A1
优先权日:2021-05-28
标 题:Synthesis of btk inhibitor and intermediates thereof
发明人：CHEN YONGGANG; CORRY JAMES; DESMOND RICHARD; DI MASO MICHAEL J; FORSTATER JACOB H; KUETHE JEFFREY T; KUHL NADINE; LARSON REED; LEVESQUE FRANCOIS; NARSIMHAN KARTHIK; OTTE DOUGLAS; PRIER CHRISTOPHER K; SHEVLIN MICHAEL; SIROTA ERIC; TAN LUSHI; THAISRIVONGS DAVID A; TURNBULL BEN W H; WANG ZHIXUN; XIAO KAIJIONG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient synthetic processes useful in the preparation of Compound A, a BTK inhibitor of Formula (I): or a pharmaceutically acceptable salt thereof, including the preparation of intermediates used to make Compound A or a pharmaceutically acceptable salt thereof.

专利号:US-12018251-B2
优先权日:2017-10-13
标 题:Method for synthesis of polynucleotides using a diverse library of oligonucleotides
发明人：VLADAR HAROLD PAUL; FERNANDES REDONDO RODRIGO APARECIDO
权利人:RIBBON BIOLABS GMBH
摘要:A method for synthesizing a target double stranded (ds) polynucleotide byproviding an oligonucleotide library within an array device that has a diversity of oligonucleotide library members, each of which has a different nucleotide sequence and is contained in a separate library containment in an aqueous solution. The library includes single stranded oligonucleotides and double stranded oligonucleotides with at least one overhang and covers at least 10,000 pairs of matching oligonucleotides. In a first step, at least a first pair of matching oligonucleotides are transferred transferred from the library into a first reaction containment using a liquid handler and the matching oligonucleotides are assembled, thereby obtaining a first reaction product comprising at least one overhang. Further reaction products are then likewise obtained and are assembled in a predetermined workflow using an algorithm, thereby producing said target ds polynucleotide with an overhang, optionally followed by a finalization step to prepare blunt ends.

专利号:US-9533959-B2
优先权日:2013-10-07
标 题:Methods of regioselective synthesis of 2,4-disubstituted pyrimidines
发明人：CHARRIER JEAN-DAMIEN; O'DONNELL MICHAEL EDWARD
权利人:VERTEX PHARMA
摘要:The present invention relates to the novel regioselective syntheses of 2,4-disubstituted pyrimidines through sequential nucleophilic aromatic substitutions.

专利号:US-11053243-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9090661-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.