CAS: 615-13-4; 1H-Inden-2(3H)-One

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CAS号95-13-6 茚 | CAS号4254-29-9 2-茚醇 | CAS号768-22-9 6,6A-二氢-1AH-茚并[... | CAS号10368-44-2 反式-2-溴茚满醇 | CAS号3349-63-1 2-茚酮肟 | CAS号201230-82-2 carbon monoxide | CAS号612-12-4 邻二氯苄 | CAS号91-13-4 α,α'-二溴邻二甲苯 | CAS号4370-02-9 1,2-二羟基茚满 | CAS号10147-11-2 3-苯基-1-丙炔 | CAS号3349-63-1 2-茚酮肟 | CAS号485-47-2 茚三酮 | CAS号33982-85-3 1-(2,3-二氢-1H-茚-... | CAS号141120-17-4 2-氨基茚满-2-膦酸 | CAS号146737-70-4 2-(2,3-dihydro-... | CAS号143246-72-4 methyl-bis(2-me... | CAS号142363-96-0 4-(1H-inden-2-y... | CAS号143356-09-6 1H-INDENE-2-ACE... | CAS号4505-48-0 2-苯基茚 | CAS号4254-29-9 2-茚醇

2-茚醇置于二甲基亚砜,三乙胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 8.0H,以79%的收率获得产物2-茚酮
参考文献:氯化膦对 Dmso 的活化:一种有效的醇氧化方法
标题:氯化膦对 Dmso 的活化:一种有效的醇氧化方法
摘要:摘要 多种醇在温和条件下被二甲基亚砜 (Dmso)-氯代磷腈络合物氧化.在这种条件下,敏感基团如甲硅烷基和四氢吡喃 (Thp) 醚是稳定的.
DOI:10.1080/00397910701572597

专利信息

专利号:US-6479685-B2
优先权日:1998-01-09
标题 :Metallocene catalysts for synthesis of high-melting polyolefin copolymer elastomers
发明人：WAYMOUTH ROBERT M; KRAVCHENKO RAISA L; MACIEJEWSKI PETOFF JENNIFER; HUNG JOYCE
权利人:TRUSTEES OF THE LELAND STANDAR
摘要:Metallocene catalysts having plural coordination geometries for synthesis of high melting polyolefin copolymers suitable as thermoplastic elastomers. The inventive catalysts comprise unbridged, substituted or unsubstituted cyclopentadienyl metallocene catalysts that are capable of inter-converting between states with different polymerization or copolymerization characteristics, which interconversion is controlled by selecting the substituents of the cyclopentadienyl ligands so that the rate of interconversion of the two states is within several orders of magnitude of the rate of formation of a single polymer chain. Where r i >r f the polymer can be characterized as multiblock; where r i
专利号:US-10336703-B2
优先权日:2015-05-12
标题 :Process for the synthesis of ivacaftor and related compounds
发明人：REDDY DUMBALA SRINIVASA; NATARAJAN VASUDEVAN; JACHAK GORAKHNATH RAJARAM
权利人:COUNCIL SCIENT IND RES
摘要:The present patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [Formula (I)], wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and Ar 1 are as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides.

专利号:US-9567308-B1
优先权日:2015-07-23
标 题:Process for the synthesis of chlorzoxazone
发明人：BOGOGNA LUIGI; CICIONE LAVINIA; BAROZZA ALESSANDRO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:Disclosed is a process for the synthesis of chlorzoxazone (1) from 4-chloro-2-aminophenol and ethyl chloroformate in the presence of a base. n n n n n n n n n n The process is particularly advantageous because it uses ethyl chloroformate instead of triphosgene, a highly dangerous reagent that releases phosgene and must be handled with extremely strict procedures to guarantee the safety of operators in industrial facilities. n Ethyl chloroformate allows the possibility of working with a number of solvents, including water. n The yield and purity of the product obtained are very high.

专利号:US-9988488-B2
优先权日:2013-03-26
标 题:Catalyst for poly(lactide) synthesis and uses thereof
发明人：CHAKRABORTY DEBASHIS; GHOSH SWARUP; RAMKUMAR VENKATACHALAM
权利人:INDIAN INSTITUTE OF TECH MADRAS
摘要:A catalysts for poly(lactide) synthesis having the structure of Formula I: n nwherein R 1 and R 2 is, independently, C 1 -C 6 alkoxy, and R 3 arylalkyl or substituted phenyl are disclosed. Method of synthesizing the catalysts and method of using the catalysts to prepare poly(lactides) and compositions comprising the catalyst are also disclosed.

专利号:US-2003203915-A1
优先权日:2002-04-05
标题 :Nitric oxide donors, compositions and methods of use related applications
发明人：FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; LIN CHIA-EN; RANATUNGA RAMANI R; RICHARDSON STEWART K; WANG TIANSHENG; WANG WEIHENG; WEY SHIOW-JYI
权利人:FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; LIN CHIA-EN; RANATUNGA RAMANI R; RICHARDSON STEWART K; WANG TIANSHENG; WANG WEIHENG; WEY SHIOW-JYI
摘要:The invention describes novel nitric oxide donors and novel compositions comprising at least one nitric oxide donor. The invention also provides novel compositions comprising at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The compounds and compositions of the invention can also be bound to a matrix. The invention also provides methods for treating cardiovascular diseases, for the inhibition of platelet aggregation and platelet adhesion caused by the exposure of blood to a medical device, for treating pathological conditions resulting from abnormal cell proliferation; transplantation rejections, autoimmune, inflammatory, proliferative, hyperproliferative, vascular diseases; for reducing scar tissue or for inhibiting wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis by administering the nitric oxide donor optionally in combination with at least one therapeutic agent. The invention also provides methods for treating inflammation, pain, fever, gastrointestinal disorders, respiratory disorders and sexual dysfunctions. The nitric oxide donors donate, transfer or release nitric oxide, and/or elevate endogenous levels of endothelium-derived relaxing factor, and/or stimulate endogenous synthesis of nitric oxide and/or are substrates for nitric oxide synthase and are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions. The therapeutic agent can optionally be substituted with at least one NO and/or NO 2 group (i.e., nitrosylated and/or nitrosated). The invention also provides novel compositions and kits comprising at least one nitric oxide donor and/or at least one therapeutic agent.

专利号:US-12110273-B2
优先权日:2022-07-26
标题:Method of preparing indolin-2-one compound and method of using indolin-2-one
发明人：LUO MEI
权利人:UNIV HEFEI TECHNOLOGY
摘要:A compound, having a structure represented by a formula (I), n n n n n n n n n n and prepared by one-pot synthesis of benzophenone hydrazone, 7-chloroisatin, and copper(II) acetate monohydrate, and refluxing in 100 mL of anhydrous methanol solvent for 48 hrs. A method for preparing the compound includes: collecting and placing 0.0235 g of benzophenone hydrazone, 0.6914 g of 7-chloroisatin, and 0.6720 g of copper(II) acetate monohydrate complex in a 100.0 mL flask; adding 50 mL of anhydrous methanol as a solvent; stirring a resulting mixture at room temperature for 48 hrs; performing column chromatography separation, and elution with petroleum ether/dichloromethane in a volume ratio of 1:1, and collecting final component points and naturally volatilizing the final component points to obtain 7(E)-chloro-3-diphenylmethylindolin-2-one crystals. The compound is used as a catalyst for reaction between benzophenone imine and trimethylsilonitrile, and has a catalytic effect with a conversion rate reaching 99%.