对苯二甲醇置于dicobalt octacarbonyl,一氧化碳,氢气体系中,化学反应生成 2-(4-甲基苯基)乙醇 参考文献:Chemistry Of The Oxo And Related Reactions. Vi. Experiments With Meta-And Para-Substituted Benzyl Alcohols 标题:Chemistry Of The Oxo And Related Reactions. Vi. Experiments With Meta-And Para-Substituted Benzyl Alcohols 摘要: DOI:10.1021/ja01136A032
专利号:US-4381400-A 优先权日:1981-02-27 标 题 :Process for the synthesis of isosorbide mononitrates 发明人:EMEURY JEAN-MARIE; WIMMER ERIC 权利人:POUDRES & EXPLOSIFS STE NALE 摘要:The invention relates to the synthesis of isosorbide mononitrates. n The process according to the invention consists in reacting a hydrazine derivative with isosorbide dinitrate, in a polar solvent medium. The reaction is preferably carried out at the reflux temperature of the solvent medium, with an excess of the hydrazine derivative. A preferred solvent medium is a mixture of tetrahydrofuran and methanol. The process leads to the preferential formation of isosorbitol-2-mononitrate, which is a coronary vasodilator.
专利号:US-8647823-B2 优先权日:2005-07-22 标 题 :Polynucleotide synthesis on a modified surface 发明人:PARK JOON-WON; HONG BONG-JIN 权利人:PARK JOON-WON; HONG BONG-JIN; POSTECH FOUNDATION; POSCO 摘要:The present invention relates to a method for the synthesis of a polynucleotide on a modified surface of a substrate, wherein the modified surface is obtained by chemically modifying with macromolecules in which a plurality of termini of the branched region are bound to the surface and a terminus of the linear region is functionalized.
专利号:US-6194612-B1 优先权日:1995-10-17 标 题:Template for solution phase synthesis of combination libraries 发明人:BOGER DALE L; CHENG SOAN; MYERS PETER L 权利人:SCRIPPS RESEARCH INST; COMBICHEM INC 摘要:This invention features a template for synthesizing combinatorial libraries, methods of synthesizing combiatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this invention.
专利号:US-4217452-A 优先权日:1974-02-09 标 题:Synthesis for the preparation of tetracyclic compounds 发明人:OLIVIE JACQUES 权利人:AKZONA INC 摘要:The invention relates to a new synthesis for the preparation of tetracyclic compounds of the general formula: ##STR1## as well as the pharmaceutically acceptable salts thereof, in which: n is the number 1 or 2, n m is the number 1, if n=2 and the number 2, if n=1, n R 1 and R 2 stand for hydrogen, hydroxy, halogen, lower alkyl (1-4 C), lower alkoxy (1-4 C) or trifluoromethyl and n R 3 represents hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or an amino alkyl group (1-6 C), in which the nitrogen atom has been substituted by two alkyl groups (1-4 C), or the nitrogen atom forms part of a heterocyclic 5- or 6-membered ring, n having valuable biological properties.
专利号:US-2009018325-A1 优先权日:2006-03-15 标 题:Process for preparing l-nucleic acid derivatives and intermediates thereof 发明人:CERCUS JACQUES; FOULKES MICHAEL; HEINZ THOMAS; NIEDERER DANIEL; SCHMITZ BEAT 权利人:CERCUS JACQUES; FOULKES MICHAEL; HEINZ THOMAS; NIEDERER DANIEL; SCHMITZ BEAT 摘要:A novel method has been found to produce 2,2′-anhydro-1-(β-L-arabinofuranosyl)thymine as a novel useful intermediate compound. A novel method has been further found to produce thymidine from 2,2′-anhydro-1-(β-L-arabinofuranosyl)thymine. According to these methods, synthesis of various L-nucleic acid derivatives, synthesis of which has been difficult till now, is possible.
专利号:US-4254031-A 优先权日:1974-02-09 标 题:Synthesis for the preparation of tetracyclic compounds 发明人:OLIVIE JACQUES 权利人:AKZONA INC 摘要:The invention relates to a new synthesis for the preparation of tetracyclic compounds of the general formula ##STR1## as well as the pharmaceutically acceptable salts thereof, in which: n is the number 1 or 2, n m is the number 1, if n=2 and the number 2, if n=1, n R 1 and R 2 stand for hydrogen, hydroxy, halogen, lower alkyl (1-4 C), lower alkoxy (1-4 C) or trifluoromethyl and n R 3 represents hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or an amino alkyl group (1-6 C), in which the nitrogen atom has been substituted by two alkyl groups (1-4 C), or the nitrogen atom forms part of a heterocyclic 5- or 6-membered ring, n having valuable biological properties.
[参考文献]: Kuo-Ching Wen, Et Al. Tyrosol And Its Analogues Inhibit Alpha-Melanocyte-Stimulating Hormone Induced Melanogenesis. Int J Mol Sci. 2013 Nov 28;14(12):23420-40.
合成参考文献
摘要:Molander, G. A.; Ryu, D., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 45. 摘要:Ilari, A.; Bonamore, A.; Boffi, A., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 166.