CAS: 113118-83-5; 5-Methoxynicotinaldehyde

相似化合物

20826-03-3 298204-74-7 1045855-73-9

上下游产品

CAS号50720-12-2 3-溴-5-甲氧基吡啶 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号937202-11-4 (5-甲氧基吡啶-3-基)甲醇 | CAS号625-92-3 3,5-二溴吡啶 | CAS号113118-74-4 phenyl 5-formyl... | CAS号20826-01-1 ethyl 5-methoxy... | CAS号7295-76-3 3-甲氧基吡啶 | CAS号113118-68-6 phenyl 3-methox... | CAS号298204-74-7 5-甲氧基烟腈 | CAS号433332-13-9 5-(5-methoxypyr...

3,5-二溴吡啶置于正丁基锂体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应生成5-甲氧基-吡啶-3-甲醛
参考文献:托达喹啉的首次全合成,这是一种来自toddalia Asiatica的生物碱.
标题:托达喹啉的首次全合成,这是一种来自toddalia Asiatica的生物碱.
摘要:该论文描述了首次从头皮中提取的生物碱-托达喹啉(toddaquinoline).关键步骤是钴(i)介导的向吡啶的径向环化.钴似乎在反应中起双重作用,首先是启动碳与卤素键的均裂,然后充当路易斯酸以促进环化成c-6.还概述了其他检查的方法.这些包括氮杂环丁烯的光环化;卤素与金属的交换以及锡介导的自由基环化引起的环化.
Doi:10.1016/s0040-4020(01)00336-2

专利信息

专利号:US-2024390383-A1
优先权日:2021-09-28
标题 :Dioxazines and their use in treatment of gba-related diseases
发明人：NEVE SØREN; BROWN WILLIAM DALBY; THIRSTRUP KENNETH
权利人:ZEVRA DENMARK AS
摘要:The present invention relates to dioxazines, their synthesis, and their use for increasing GBA activity and/or levels as well as treatment of GBA-related diseases, such as Parkinson's disease.

专利号:WO-2024159287-A1
优先权日:2023-01-30
标 题:Nav1.7- and/or nav1.8-inhibiting hydroxamates, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT’ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The invention relates to Nav1.7- and/or Nav1.8-inhibiting hydroxamates. More specifically, the present invention relates to hydroxamates that comprise formula (I): (I), in which the substituents R1 to R10, as well as the derivatives thereof, R11 to R20, are selected independently of the groups defined in the description, as well as to the processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.