专利号:WO-2025045973-A1 优先权日:2023-08-31 标题 :Synthesis of lanifibranor intermediate 发明人:BOUBIA BENAÃ?SSA; GONZALEZ JÉRÔME; BELL FRÉDÉRIC 权利人:INVENTIVA 摘要:The present disclosure is directed to a process for preparing a compound of formula (I), which comprises a palladium-free coupling reaction between N-(4-chloro-2-iodo-phenyl)-1,3-benzothiazole-6-sulfonamide and methyl 5-hexynoate in the presence of a copper catalyst.
专利号:US-12007376-B2 优先权日:2014-02-26 标题 :Method for determining a concentration of a synthesis component in a radiopharmaceutical sample 发明人:LEBEDEV ARTEM Y; ELIZAROV ARKADIJ M 权利人:TRACE ABILITY INC 摘要:A method for determining a concentration of a synthesis component in a radiopharmaceutical sample comprises providing an indicator, a metal or a metal complex, contacting the radiopharmaceutical sample with the indicator, metal or metal complex for a period of time sufficient to obtain an interaction, measuring an optical characteristic of the interacted components, and determining a concentration of the synthesis component in the radiopharmaceutical sample based on the measured optical characteristic.
专利号:US-2023097824-A1 优先权日:2020-05-08 标 题:Semi-synthesis and use of racemic hematoxylin 发明人:DURRANT EDWARD E; HEINDL DIETER; HUBER FLORIAN MAURITIUS ERASUMU; KLEIN ERIC; KOSMEDER II JEROME W; VOSS EDGAR 权利人:VENTANA MED SYST INC; ROCHE DIAGNOSTICS OPERATIONS INC 摘要:A racemic hematoxylin formulation is disclosed that includes one or both of a stabilizer compound and an antioxidant. The disclosed composition exhibits sufficient stability to be utilized in an automated staining process. Methods of using and making the stabilized composition also are disclosed.
专利号:US-2002077491-A1 优先权日:2000-09-05 标 题 :Methods for forming combinatorial libraries combining amide bond formation with epoxide opening 发明人:SHIPPS GERALD W; ROSNER KRISTIN E; MAKARA GERGELY M; WINTNER EDWARD A; NASH HUW M; FELSCH JASON S; PAL KOLLOL; LENZ GEORGE R 摘要:The invention relates to methods for forming combinatorial libraries. The invention provides methods suitable for the rapid and convenient synthesis of very large combinatorial libraries of small organic molecules. In particular, the invention provides a method for forming combinatorial libraries combining amide bond formation with epoxide opening.
专利号:US-2004076623-A1 优先权日:2000-07-14 标题:Activated modular grafted polymeric surfaces 发明人:EDE NICHOLAS JON; ERCOLE FRANCESCA; TRIBBICK GORDON; SANDAYAKE SAMAN; PERERA SENAKE 摘要:The present invention relates generally to new surfaces for solid phase chemistry applications, more specifically plastics surfaces modified by graft polymerisation for use in chemical synthesis and/or immobilisation of chemical entities and/or compounds. n In particular the invention relates to an activated modular grafted polymeric surface, which is suitable for use as a reagent for solid phase organic synthesis, or as a reagent for the affinity capture, presentation or preparation of biomolecules such as proteins, oligonucleotides, nucleic acids, peptides, and lectins. The grafted polymeric surfaces of the invention are particularly useful as scavenger reagents in combinatorial synthetic protocols, and as affinity reagents in protein purification and proteomics.
专利号:US-10309947-B2 优先权日:2013-02-27 标题:System and method for radiosynthesis, quality control and dose dispensing 发明人:ELIZAROV ARKADIJ; LEBEDEV ARTEM 权利人:TRACE ABILITY INC 摘要:A system and method for performing radiochemical synthesis, analysis and/or dispensing of radiopharmaceuticals using specially designed disposable components: palettes and caddies, the palette being an assembly of containers not connected with each other for direct material transfer; the caddy being a disposable component used to transfer material between containers on the palettes and/or other locations.
参考文献:10.1007/s00223-009-9326-7 摘要:Lacruz RS, Nanci A, Kurtz I, Wright JT, Paine ML. Regulation of pH During Amelogenesis. Calcified Tissue International. 2009 Dec 17;86(2):91–103. doi: 10.1007/s00223-009-9326-7.