专利号:WO-2024041503-A1 优先权日:2022-08-22 标 题:Compounds targeting y220c mutant of p53 发明人:LI SUJING; LI AMIN; ZHENG QIAN; Dang Chaojie; FAN XINRUI; LONG WEI; WANG YANPING 权利人:JACOBIO PHARMACEUTICALS CO LTD 摘要:The present invention discloses compounds of formula (I) which can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. Also provided are processes for the synthesis and use of the compounds of formula (I).
专利号:US-4552967-A 优先权日:1984-01-12 标 题:Process for the synthesis of intermediates in the preparation of diaminopyridines 发明人:GREENE JAMES M; LAVAGNINO EDWARD R; PIKE ANDREW J; TAYLOR EDWARD C 权利人:LILLY CO ELI 摘要:The present invention relates to a process for preparing aminonitropyridines comprising reacting an alkoxynitropyridine with ammonium acetate.
专利号:CA-1256881-A 优先权日:1984-01-12 标题 :Process for the synthesis of aminonitropyridines
专利号:EP-0149537-A2 优先权日:1984-01-12 标题:Process for the synthesis of aminonitropyridines
专利号:EP-0149537-B1 优先权日:1984-01-12 标 题:Process for the synthesis of aminonitropyridines
专利号:SU-1745721-A1 优先权日:1990-10-22 标题:Method of vicinal-substituted 3-hydroxylaminopyridines synthesis
参考标题:The Suzuki-Miyaura Coupling Of Nitroarenes 作者:M. Ramu Yadav,Masahiro Nagaoka,Myuto Kashihara,Rong-Lin Zhong,Takanori Miyazaki,Shigeyoshi Sakaki,Yoshiaki Nakao |发布日期:2017.7.19 摘要:Synthesis Of Biaryls Via The Suzuki-Miyaura Coupling (Smc) Reaction Using Nitroarenes As An Electrophilic Coupling Partners Is Described. Mechanistic Studies Have Revealed That The Catalytic Cycle Of This Reaction Is Initiated By The Cleavage Of The Aryl-Nitro (Ar-No2) Bond By Palladium, Which Represents An Unprecedented Elemental Reaction.