CAS: 24280-93-1; (E)-6-(4-Hydroxy-6-Methoxy-7-Methyl-3-Oxo-1,3-Dihydroisobenzofuran-5-yl)-4-Methylhex-4-Enoic Acid

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CAS号31858-66-9 麦考酚酸甲酯-d6(EP杂质E) | CAS号35334-60-2 (E)-6-acetoxy-4... | CAS号100045-79-2 (E)-acetic acid... | CAS号100045-80-5 (E)-1-acetoxy-6... | CAS号100045-81-6 (E)-3-methyl-6-... | CAS号100045-82-7 (E)-8-(tert-but... | CAS号100045-85-0 (E)-2-(6-(tert-... | CAS号100045-86-1 (E)-2-bromo-6-(... | CAS号60435-90-7 6-O-甲基麦考酚酸甲酯 | CAS号31858-66-9 麦考酚酸甲酯-d6(EP杂质E) | CAS号31858-65-8 O-去甲基麦考酚酸 | CAS号527-55-9 4,5-二甲基间苯二酚 | CAS号26675-76-3 7-hydroxy-5-met... | CAS号24243-38-7 3-(5-methoxy-2,... | CAS号27004-95-1 mycophenolate n... | CAS号115007-34-6 吗替麦考吩酯 | CAS号171808-04-1 甲基6’-去甲基-4’-对甲苯... | CAS号171808-03-0 4'-DESMETHYL-6'...

7-Hydroxy-6-[(E)-6-Hydroxy-3-Methylhex-2-Enyl]-5-Methoxy-4-Methyl-3H-2-Benzofuran-1-One置于jones Reagent体系中,用 丙酮 用作溶剂,化学反应 5.0H,以61%的收率获得霉酚酸
参考文献:霉酚酸的全合成
标题:霉酚酸的全合成
摘要:这些合成 A Partir De T-丁基二甲基甲硅烷氧基-8 (=r-8) 甲氧基-1 甲基-5 辛烯-4Yne-1 和去甲氧基甲氧基甲基-3 (=r'-3) 甲基-2 环丁烯-2One-1 通过环化 De L' 酸 R-3 R'-6 羟基-2 甲氧基-4 甲基-5 苯甲酸
Doi:10.1021/ja00264A038

专利信息

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-10973847-B2
优先权日:2017-06-30
标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof
发明人：JOHNSON JEREMIAH A; GOLDER MATTHEW R
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

专利号:WO-2004089946-A1
优先权日:2003-04-07
标题:Microwave synthesis of mycophenolate
发明人：ADHIKARY LAXMI; SURYANARAYAN SHRIKUMAR
权利人:BIOCON LTD; ADHIKARY LAXMI; SURYANARAYAN SHRIKUMAR
摘要:A process for synthesis of a compound of formula (I) using microwave irradiation.

专利号:US-2025236876-A1
优先权日:2024-01-22
标题:Engineered yeast for efficient and rapid synthesis of erythritol and construction method thereof
发明人：CHENG HAIRONG; XU SHUO
权利人:UNIV SHANGHAI JIAOTONG
摘要:Disclosed are an engineered yeast for efficient and rapid synthesis of erythritol and a construction method thereof. Yarrowia lipolytica is used as a synthetic chassis for genetic improvement. A method for synthesizing erythritol is as follows: using glucose as a carbon source, and a nitrogen source and an inorganic salt as raw materials, sterilizing a medium, cooling the sterilized medium before inoculating yeast Yarrowia lipolytica , performing continuous fermentation or fed-batch fermentation under the condition of oxygen supply, and purifying erythritol from a fermentation broth. Under the condition of continuous feeding, the yield of erythritol is more than 350 g/L, and the production efficiency is more than 4.5 g/L·h, nearly 100% higher than that of a comparative strain.

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as