CAS: 372-31-6; Ethyl 4,4,4-Trifluoro-3-Oxobutanoate

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372-30-5 352-24-9 127146-29-6

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Sodium 4-Ethoxy-1,1,1-Trifluoro-4-Oxobut-2-En-2-Olate置于盐酸体系中,用 水 作为反应溶剂,化学反应 3.0H,反应生成 三氟乙酰乙酸乙酯
参考文献:A Process For The Preparation Of Alkyl 3-Difluoromethyl-1-Methyl-1H-Pyrazole-4-Carboxylate And Its Analogs
标题:A Process For The Preparation Of Alkyl 3-Difluoromethyl-1-Methyl-1H-Pyrazole-4-Carboxylate And Its Analogs
摘要:该披露提供了一种制备烷基3-二氟甲基-1-甲基-1H-吡唑-4-羧酸酯及其类似物的过程.该过程包括一种用于claisen缩合的反应工作方法,其中在去除剩余的起始物质和副产物(如乙醇和过量的乙酸乙酯)后,使烯醇盐酸化.该过程还包括一种在下一步使用烷基二氟乙酰乙酸酯及其类似物之前完全干燥的方法,即通过将三烷基正甲酸酯与残留水反应.该过程包括使用na2Co3和/或k2Co3促进环闭合反应,以产生烷基3-二氟甲基-1-甲基-1H-吡唑-4-羧酸酯.该过程还包括通过在混合溶剂体系中沉淀的方式有效去除环闭合的副产物烷基3-二氟甲基-2-甲基-1H-吡唑-4-羧酸酯,从而消除了对最终产品的再结晶的需要.

专利信息

专利号:US-6252105-B1
优先权日:1998-07-06
标题:Synthesis of low-fluoride organic compounds
发明人：BRAUN MAX; EICHER JOHANNES; JANSSENS FRANCINE; EICHHOLZ KERSTIN; PALSHERM STEFAN
权利人:SOLVAY FLUOR & DERIVATE
摘要:Organic compounds, e.g. fluorinated organic compounds such as fluorinated carboxylic acids or fluorinated carboxylic acid chlorides, may contain small amounts of carboxylic acid fluorides, hydrogen fluoride or hydrolyzable fluoride, which during the preparation of derivatives of the fluorinated organic compounds, for example by esterification, may yield corrosive fluorides or hydrogen fluoride. The invention is a method for the synthesis and/or purification of preferably fluorinated organic compounds such as carboxylic acids, carboxylic acid chlorides and derivatives such as esters thereof, starting from corresponding carboxylic acid chlorides containing acid fluorides or hydrolyzable fluoride, and alcohols under the catalytic action of 'onium' salts of carboxylic acids, to obtain products which have a low fluoride content. Alternatively, an inorganic oxide adsorbent is utilized. The method is especially suitable for the synthesis of esters of trifluoroacetic acid, chlorodifluoroacetic acid, trifluoroacetoacetic acid and/or difluoroacetoacetic acid.

专利号:WO-2010144434-A1
优先权日:2009-06-09
标题 :Derivatives of mefloquine and associated methods for making and using
发明人：DOW GEOFFREY S; MILNER ERIN E; WIPF PETER; MO TINGTING
权利人:US OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF U S; DOW GEOFFREY S; MILNER ERIN E; WIPF PETER; MO TINGTING
摘要:The present invention relates to new mefloquine derivatives and therapeutic compositions comprising one or more mefloquine derivatives. Mefloquine derivatives of the invention have a pentafluorosulfanyl moiety substitution at the 8-position. Certain mefloquine derivatives further include a quinoline methanol moiety substitution at the 4-position. The present invention also relates to new intermediate compounds useful in the synthesis of the mefloquine derivatives, which intermediates also have a pentafluorosulfanyl moiety substitution at the 8-position.

专利号:US-2023303546-A1
优先权日:2020-03-05
标题:Process And Intermediates For The Preparation Of Pyroxasulfone
发明人：RECSEI CARL; BARDA YANIV
权利人:ADAMA AGAN LTD
摘要:The invention relates to a process for preparing a key intermediate of Formula (I) in the synthesis of pyroxasulfone. The process comprises reacting an isoxazole of Formula (II) with a thionating reagent to create an S-substituted thioisoxazole of Formula (III); and combining the S-substituted thioisoxazole of Formula (III) with a pyrazole of the Formula (IV) by introducing a methylene bridge, to obtain a compound of Formula (I). The invention also relates to novel S-substituted thioisoxazole of Formula (III) and processes of preparation thereof, wherein L1 is halogen or an anionic residue derived from an acid; R is an organic residue derived from a suitable thionating reagent: dimethyl thioformamide, thiosulfate salts, dithiooxamide, alkyl xanthate salts, thiobenzamide, V-substituted thiourea and thioacetate salts.

专利号:US-2005106689-A1
优先权日:2002-03-21
标 题:Synthesis of aminocrotonates
发明人：BRAUN MAX; BRAUKMUELLER SASKIA
权利人:SOLVAY FLUOR & DERIVATE
摘要:3-aminocrotonate compounds, e.g. diesters, which are substituted on the C-4 atom by at least two chlorine and/or fluorine atoms, are produced by reacting corresponding acetoacetate compounds with ammonia and primary and secondary amines while simultaneously or subsequently eliminating water. The reaction is carried out in the presence of onium salts formed from primary or secondary amines and carboxylic acids. Preferably, two phases are formed; one phase containing the crotonate compound product with a good degree of purity and the other phase containing the onium salt and water.

专利号:US-11512097-B2
优先权日:2019-11-25
标题 :Heterocyclic compounds as Delta-5 desaturase inhibitors and methods of use
发明人：ALLEN JENNIFER R; BELTRANI MICHELA; BOURBEAU MATTHEW P; DAMYANOVA TEODORA P; LINGARD IAIN; MINATTI ANA E; VINCETTI PAOLO
权利人:AMGEN INC
摘要:The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5Dâ€?). The compounds have a general Formula I n nwherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-8513429-B2
优先权日:2002-08-23
标 题:Synthesis of epothilones, intermediates thereto and analogues thereof
发明人：DANISHEFSKY SAMUEL J; RIVKIN ALEXEY; FUMIKIKO YOSHIMURA; CHOU TING-CHAO; GABARDA ANA E; DONG HUAJIN
权利人:DANISHEFSKY SAMUEL J; RIVKIN ALEXEY; FUMIKIKO YOSHIMURA; CHOU TING-CHAO; GABARDA ANA E; DONG HUAJIN; SLOAN KETTERING INSITUTE FOR CANCER RES
摘要:The present invention provides compounds of formula (I): n n n n n n n n n n n n as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).