专利号:US-4906767-A 优先权日:1987-06-30 标题:Monomers with urea groups 发明人:MATHIAS LON J; KURZ DAVID W 权利人:UNIV SOUTHERN MISSISSIPPI 摘要:There is disclosed a family of new vinyl monomers capable of forming polymers by free radical polymerization. The vinyl monomer is of the formula ##STR1## wherein R 1 and R 2 are substituted or unsubstituted hydrocarbons, X is O, NH or NR 3 , and R 3 is substituted or unsubstituted hydrocarbon. n The intermediates in the synthesis of these monomers are new beta-chloroalanine ureas. The polymers are useful in film and fiber formation and display good toughness. These new vinyl monomers also form a cyclic monomer.
专利号:US-4985522-A 优先权日:1987-06-30 标题:Polymers containing pendant urea groups 发明人:MATHIAS LON J; KURZ DAVID W 权利人:UNIV SOUTHERN MISSISSIPPI 摘要:There is disclosed a family of new vinyl monomers capable of forming polymers by free radical polymerization. The vinyl monomer is of the formula ##STR1## wherein R 1 and R 2 are substituted or unsubstituted hydrocarbons, X is O, NH or NR 3 , and R 3 is substituted or unsubstituted hydrocarbon. n The intermediates in the synthesis of these monomers are new beta-chloroanaline ureas. The polymers are useful in film and fiber formation and display good toughness. These new vinyl monomers also form a cyclic monomer.
专利号:CN-102924499-B 优先权日:2012-10-22 标 题 :Synthesis of L-3,4,5-trioxo-phenylalanine/aldehyde compound
专利号:CN-115872882-B 优先权日:2021-09-27 标 题:Synthesis method of 3-chloro-alanine
[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1028. [参考文献]: Babita S Gupta, Et Al. Role Of Sphingosine Synthesis Inhibition In Transcutaneous Delivery Of Levodopa. Int J Pharm. 2002 May 15;238(1-2):43-50. [参考文献]: Benjamin Adams, Et Al. Stereochemistry Of Reactions Of The Inhibitor/substrates L- And D-Beta-Chloroalanine With Beta-Mercaptoethanol Catalysed By L-Aspartate Aminotransferase And D-Amino Acid Aminotransferase Respectively. Org Biomol Chem. 2005 Sep 21;3(18):3357-64. [参考文献]: Brooke S Wright, Et Al. Synthesis Of 4-Hydroxysphinganine And Characterization Of Sphinganine Hydroxylase Activity In Corn. Arch Biochem Biophys. 2003 Jul 15;415(2):184-92. [参考文献]: Jorge Cerbón, Et Al. Inositol Phosphoceramide Synthase Is A Regulator Of Intracellular Levels Of Diacylglycerol And Ceramide During The G1 To S Transition In Saccharomyces Cerevisiae. Biochem J. 2005 May 15;388(Pt 1):169-76.
合成参考文献
参考文献:10.1016/j.bbrc.2023.08.050 摘要:Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and Biophysical Research Communications. 2023 Oct;679():116–21. doi: 10.1016/j.bbrc.2023.08.050.