CAS: 84366-81-4; (((2R,3S,4R,5R)-5-(6-Amino-9H-Purin-9-yl)-3,4-Dihydroxyoxolan-2-yl)Methoxy)(((((2R,3S,4S)-5-(7,8-Dimethyl-2,4-Dioxo-2H,3H,4H,10H-Benzo[g]Pteridin-10-yl)-2,3,4-Trihydroxypentyl)Oxy)(Hydroxy)Phosphoryl)Oxy)Phosphinic Acid Disodium Salt

专利信息

专利号:US-12037623-B2
优先权日:2018-07-09
标 题 :Enzymatic synthesis of 4′-ethynyl nucleoside analogs
发明人：HUFFMAN MARK A; FRYSZKOWSKA ANNA; KOLEV JOSHUA N; DEVINE PAUL N; CAMPOS KEVIN R; TRUPPO MATTHEW; NAWRAT CHRISTOPHER C
权利人:MERCK SHARP & DOHME; MERCK SHARP & DOHME LLC
摘要:The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on the intermediates, improves the stereoselectivity of glycosylation and reduces the number of process steps needed to make said compounds. It also relates to the novel intermediates employed in the process.

专利号:US-2024301460-A1
优先权日:2018-07-09
标题 :Enzymatic synthesis of 4'-ethynyl nucleoside analogs

专利号:BR-112021000202-B1
优先权日:2018-07-09
标题 :METHODS FOR ENZYME SYNTHESIS OF 4'-ETHYNYL 2-DEOXY NUCLEOSIDE AND COMPOUNDS

专利号:JP-7482188-B2
优先权日:2018-07-09
标题 :Enzymatic synthesis of 4'-ethyl nucleoside analogues

专利号:JP-2023123750-A
优先权日:2018-07-09
标 题:Enzymatic Synthesis of 4'-Ethyl Nucleoside Analogues

专利号:US-2024092818-A1
优先权日:2020-12-18
标题:Synthesis of antiviral nucleosides