CAS: 91-85-0; N1-(4-Methoxybenzyl)-N2,N2-Dimethyl-N1-(Pyrimidin-2-yl)Ethane-1,2-Diamine

该化合物是属于氨类的有机化合物,其特点是芳香结构,包括附属于一个矿物质功能组的苯基组,该化合物一般为白色至白色固体,以用于各种用途而闻名,包括作为合成药物和农用化学的中间体.Tonzylamine在水中表现出中等溶解性,并且更溶于有机溶剂,反映其非生物特性.该化合物具有相对较低的挥发性,在标准条件下保持稳定.该化合物可能由于有矿物质组的存在而具有基本特性,允许其参与酸基反应.安全数据表明,应当谨慎地处理Tonzylamine,因为它可能会引起皮肤和眼睛的刺激.

结构式图片

上下游产品

CAS号2393-23-9 对甲氧基苄胺 | CAS号6957-21-7 N-(4-甲氧苄基)嘧啶-2-胺 | CAS号107-99-3 2-氯-N,N-二甲基乙胺 | CAS号90042-89-0 4,6-dichloro-N-... | CAS号1722-12-9 2-氯嘧啶 | CAS号65875-39-0 N'-(4-methoxy-b... | CAS号68303-34-4 N-[2-(dimethyla... | CAS号726-18-1 4,4'-二甲氧基二苯基甲烷

合成工艺路线路线简述

    4,6-Dicloro-2-P.Metossibenzilaminopirimidina置于palladium On Activated Charcoal Sodium Hydroxide,四丁基氯化铵,氢气体系中,用 乙醇,水 作为反应溶剂,25.0~70.0 °C,784.48 Kpa 条件下,反应 15.0H,反应生成 松齐拉敏
    参考文献:Mossini; Maggiali; Morini,Farmaco,Edizione Scientifica,1984,Vol. 39,# 3,P. 189-199
    标题:Mossini; Maggiali; Morini,Farmaco,Edizione Scientifica,1984,Vol. 39,# 3,P. 189-199

    海关参考信息

    专利信息


    专利号:EP-4198027-A1
    优先权日:2021-12-14
    标题:Sustainable process for the synthesis of molecules with antihistamine activity in unconventional biodegradable solvents (deep eutectic solvents)
    发明人:QUIVELLI ANDREA FRANCESCA; CAPRIATI VITO; PERNA FILIPPO MARIA; VITALE PAOLA; ROSSI FEDERICO VITTORIO; GARCÃ?A - Ã?LVAREZ JOAQUÃ?N
    权利人:UNIV DEGLI STUDI DI BARI; UNIV OVIEDO
    摘要:The present invention relates to a sustainable synthetic process for obtaining ethylenediamines molecules with antihistamine activity whose production costs are considerably reduced by employing unconventional biodegradable solvents, such as the Deep Eutectic Solvents, with considerable advantages from a point of view both of the environmental and economic impact.

    专利号:US-2023271983-A1
    优先权日:2020-07-29
    标题 :Functionalized isonitriles and products, preparation and uses thereof
    发明人:SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
    权利人:UNIV SANTIAGO COMPOSTELA
    摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

    专利号:TW-434329-B
    优先权日:1997-04-03
    标 题:Synthesis of onium hydroxides from onium salts

    专利号:US-2007148246-A1
    优先权日:2005-08-11
    标题:Nucleic Acid-Based Matrixes
    发明人:LUO DAN; LI YOUGEN
    权利人:LUO DAN; LI YOUGEN
    摘要:Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include delivery of biologically active agents, cell and tissue culture, and cell-free protein synthesis.

    专利号:US-8486621-B2
    优先权日:2005-08-11
    标题 :Nucleic acid-based matrixes
    发明人:LUO DAN; UM SOONG HO
    权利人:LUO DAN; UM SOONG HO; CORNELL RES FOUNDATION INC
    摘要:Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include cell-free protein synthesis.
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    主要参考文献


    1: Sabry SM, Abdel-Hay MH, Barary MH, Belal TS. Sensitive spectrofluorimetric and spectrophotometric methods for the determination of thonzylamine hydrochloride in pharmaceutical preparations based on coupling with dimethylbarbituric acid in presence of dicyclohexylcarbodiimide. J Pharm Biomed Anal. 2000 Mar;22(2):257-64. doi: 10.1016/s0731-7085(99)00261-7. 27(24):115127. doi: 10.1016/j.bmc.2019.115127. Epub 2019 Nov 1. 77(4):641-3. doi: 10.3181/00379727-77-18876. 9(2):35-8. 18(12):509-11.
    123:419-29. 38(6):873-80. 39(3):189-99. Italian. 74(1):190-1. 92(4):411-6. Japanese. doi: 10.1248/yakushi1947.92.4_411.

    合成参考文献


    摘要:Journal of Allergy., 19(313), 1948
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