CAS: 13831-31-7; Acetoxyacetylchloride

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CAS号13831-30-6 乙酰氧基乙酸 | CAS号79-14-1 羟基乙酸 | CAS号75-36-5 乙酰氯 | CAS号108-24-7 乙酸酐 | CAS号39561-82-5 2-(4-氯苯基)-2-氧代乙酸乙酯 | CAS号366-78-9 2-(4-氟苯基)-2-氧代乙酸乙酯 | CAS号582-24-1 2-羟基苯乙酮 | CAS号98-86-2 苯乙酮 | CAS号27536-15-8 [2-(1H-indol-3-... | CAS号25769-61-3 乙酸酐二乙酸酯 | CAS号78273-80-0 罗沙替丁 | CAS号78314-12-2 5-[[2-(Acetylox... | CAS号65143-37-5 2-氧代-2-(对甲苯基)乙酸乙酯 | CAS号35594-15-1 ethyl 4-acetoxy...

乙酰氧基乙酸置于草酰氯,N,N-二甲基甲酰胺体系中,用 二氯甲烷 用作溶剂,化学反应 3.0H,反应生成乙酰氧基乙酰氯
参考文献:一种瑞舒伐他汀钙中间体及其制备方法和应 用
标题:一种瑞舒伐他汀钙中间体及其制备方法和应 用
摘要:本发明公开了一种瑞舒伐他汀钙中间体及其制备方法和应用,该中间体合成工艺环境友好,操作简便,Ehs风险低,原料易得,所用化学试剂毒性小,价格低廉,是适合于工业化生产的绿色合成工艺.而且,本发明提供的中间体应用于瑞舒伐他汀钙及其关键中间体的合成,路线较短,收率高,有效地降低了瑞舒伐他汀钙工业化的生产成本,具有较高的工业应用前景.

专利信息

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-8278440-B2
优先权日:2010-02-17
标 题:Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：PEGLION JEAN-LOUIS; CAIGNARD PASCAL
权利人:PEGLION JEAN-LOUIS; CAIGNARD PASCAL; SERVIER LAB
摘要:Process for the synthesis of ivabradine of formula (I): n nand addition salts thereof with a pharmaceutically acceptable acid.

专利号:US-5300638-A
优先权日:1991-07-31
标题:Asymmetric synthesis of taxol side chain
发明人：FARINA VITTORIO; HAUCK SHEILA I
权利人:BRISTOL MYERS SQUIBB CO
摘要:The present invention relates to a process for the preparation of (3R, 4S)-3-hydroxy-4-phenyl-2-azetidinone derivatives which are useful intermediates in the synthesis of taxol from baccatin III, said process comprises reacting an acyloxyacetyl halide with an imine derived from L-threonine; and to compounds of formula (III) which are produced in said process: ##STR1## wherein Ar is phenyl; R 1 is hydrogen, an acyl radical of a carboxylic acid, or a carbonic acid ester radical; R 2 is hydrogen or a carboxy protecting group; and R 3 is hydrogen or a hydroxy protecting group.

专利号:WO-9316981-A1
优先权日:1992-02-28
标 题:Synthesis of ioversol using a minimal excess of acetoxyacetylchloride
发明人：MC CARTHY WILLIAM Z; KNELLER MILLS THOMAS; LIN YOULIN; WALLACE REBECCA ABERNATHY; WHITE DAVID HILL
权利人:MALLINCKRODT MEDICAL INC
摘要:The use of a minimal excess of acetoxyacetylchloride as a reagent in the synthesis of N, N'-bis (2,3-dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6-triiodoisophthalamide.

专利号:US-5177261-A
优先权日:1991-07-22
标题 :Synthesis of ioversol using chloroacetyl chloride
发明人：MCCARTHY WILLIAM Z; KNELLER MILLS T; LIN YOULIN; WHITE DAVID H
权利人:MALLINCKRODT MEDICAL INC
摘要:The use of chloroacetylchloride as an alternative or substitute reagent for acetoxychloride in the synthesis of N,N'- bis (2,3-dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6-triiodoisophthalamide.

专利号:US-5371278-A
优先权日:1994-03-25
标题 :Synthesis of ioversol using a minimal excess of acetoxyacetylchloride
发明人：MCCARTHY WILLIAM Z; KNELLER MILLS T; LIN YOULIN; WALLACE REBECCA A; WHITE DAVID H
权利人:MALLINCKRODT MEDICAL PMC
摘要:The use of a minimal excess of acetoxyacetylchloride as a reagent in the synthesis of N,N'-bis(2,3-dihydroxypropyl)-5-N-(2-hydroxy-ethyl)glycolamido-2,4,6-triiodoisophthalamide.