CAS: 2295-58-1; 1-(2,4,6-Trihydroxyphenyl)Propan-1-One

该化合物是属于丙酸衍生物类别的化学化合物,其特点是独特的分子结构,其中包括一种有独特特性的特定功能组群经过改造的丙基酸脊柱,其用途通常在各个领域,包括药品和农用化学品方面得到承认,该化合物可能具有中度有机溶剂溶解性等特性,并视其功能组别而与其他化学物种发生潜在反应.其安全特征,包括毒性和环境影响,需要通过具体研究加以评估,对任何化学物质都一样.此外,该化合物在不同条件下的稳定性,如温度和pH值,对于其处理和储存至关重要.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

3,5-dihydroxyphenol propionic acid anhydride propiononitrile propionyl chloride2,2,4-tris-(3-methyl-but-2-enyl)-6-propionyl-cyclohexane-1,3,5-trione 1-(2,4,6-trihydroxy-3-(3-methylbut-2-enyl)phenyl)propan-1-one 5,7-Dihydroxy-3-methylflavone 3-diphenylmethyl-2,4,6-trihydroxypropiophenone

合成工艺路线路线简述

    2,4,6-Triacetoxypropiophenone置于sodium Hydroxide体系中,用 乙醇 用作溶剂,化学反应生成夫洛丙酮
    参考文献:邻-酰氧基苯基烷基酮的烯醇酯的环化-Ii:对反应机理的贡献
    标题:邻-酰氧基苯基烷基酮的烯醇酯的环化-Ii:对反应机理的贡献
    摘要:邻-酰氧基苯基烷基酮1的烯醇的碱催化环化可能只涉及baker-Venkataraman 2型反应,而claisen-Haase重排3不可能同时发生.在碱水溶液的存在下,烯醇乙酸酯产生碳负离子,并且碳负离子与相邻的酯基反应,导致闭环成γ-吡喃酮.
    Doi:10.1016/0040-4020(69)85002-7

    海关参考信息

    专利信息


    专利号:US-5583081-A
    优先权日:1993-08-31
    标 题 :Copper-containing zeolite catalysts
    发明人:PRICE GEOFFREY L; KANAZIREV VLADISLAV
    权利人:UNIV LOUISIANA STATE; BULGARIAN ACADEMY OF SCIENCES
    摘要:A catalyst useful in the conversion of nitrogen oxides or in the synthesis of nitriles or imines from amines, formed by preparing an intimate mechanical mixture of a copper (II)-containing species, such as CuO or CuCl 2 , or elemental copper, with a zeolite having a pore mouth comprising 10 oxygen atoms, such as ZSM-5, converting the elemental copper or copper (II) to copper (I), and driving the copper (I) into the zeolite.

    专利号:US-7993390-B2
    优先权日:2002-02-08
    标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
    发明人:MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN
    权利人:BOSTON SCIENT SCIMED INC
    摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.

    专利号:US-7427690-B2
    优先权日:2004-06-05
    标 题 :Multifunction “crown complexesâ€? from amino acids and peptides for skin and hair restoration
    发明人:GUPTA SHYAM K
    权利人:BIODERM RESEARCH
    摘要:This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2 . The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.
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    主要参考文献


    1: Ohgaki K. Efficacy of Naftopidil as a Medical Expulsive Therapy in Japanese Men With Ureteral Stones: A Prospective Randomized Controlled Study. J Clin Med Res. 2019 Jul;11(7):495-500. doi: 10.14740/jocmr3843. Epub 2019 Jun 11.
    2: Aso Y, Yoshioka S, Kojima S. Relationship between the crystallization rates of amorphous nifedipine, phenobarbital, and flopropione, and their molecular mobility as measured by their enthalpy relaxation and (1)H NMR relaxation times. J Pharm Sci. 2000 Mar;89(3):408-16. doi: 10.1002/(SICI)1520-6017(200003)89:3<408::AID-JPS11>3.0.CO;2-#. 33(12):2125-9. doi: 10.1007/s00345-015-1556-x. Epub 2015 Apr 14. 15(10):748-54. Japanese. 23(10):2277-90. doi: 10.1007/s11095-006-9079-1. Epub 2006 Aug 24.

    合成参考文献


    参考文献:10.1007/s11095-006-9079-1
    摘要:Bhugra C, Shmeis R, Krill SL, Pikal MJ. Predictions of Onset of Crystallization from Experimental Relaxation Times I-Correlation of Molecular Mobility from Temperatures Above the Glass Transition to Temperatures Below the Glass Transition. Pharmaceutical Research. 2006 Aug 24;23(10):2277–90. doi: 10.1007/s11095-006-9079-1.
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