CAS: 330-12-1; 4-(Trifluoromethoxy)Benzoic Acid

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CAS号332-25-2 对三氟甲氧基苯腈 | CAS号124-38-9 二氧化碳 | CAS号407-14-7 1-溴-4-三氟甲氧基苯 | CAS号456-71-3 4-(三氟甲氧基)苯甲酰胺 | CAS号36823-88-8 4-(三氟甲氧基)苯甲酰氯 | CAS号784-77-0 3-硝基-4-(三氟甲氧基)苯甲酸 | CAS号85013-98-5 4-(三氟甲氧基)苯乙酮 | CAS号65796-00-1 4-三氟甲氧基氯苄 | CAS号659-28-9 对三氟甲氧基苯甲醛 | CAS号4315-07-5 4-(三氟甲氧基)苯基乙酸 | CAS号1736-74-9 4-(三氟甲氧基)苄醇 | CAS号897656-36-9 N-methoxy-N-met...

1-乙烯基-4-(三氟甲氧基)苯置于乙二醇二丁醚,氧气体系中,化学反应 12.0H,反应生成 4-三氟甲氧基苯甲酸
参考文献:1,2-二丁氧基乙烷促进在清洁条件下使用 O2 将烯烃氧化裂解为羧酸
标题:1,2-二丁氧基乙烷促进在清洁条件下使用 O2 将烯烃氧化裂解为羧酸
摘要:在此,我们报告了第一个在清洁条件下使用 1,2-二丁氧基乙烷/o 2系统将烯烃氧化裂解为羧酸的有效且绿色方法的例子.这种新型氧化系统还具有优异的官能团耐受性,适用于大规模合成.通过一锅式顺序转化,无需外部引发剂,催化剂和添加剂,以非常好至极好的收率制备了目标产物.
DOI:10.1021/acs.Joc.1C01701

专利信息

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:US-4665074-A
优先权日:1984-05-10
标 题:6-(polyfluoroalkoxyphenyl) pyridazinones, their compositions, synthesis and use
发明人：AMSCHLER HERMANN
权利人:BYK GULDEN LOMBERG CHEM FAB
摘要:6-aryl-3[2H]pyridazinones of formula I (I) in which one of the substituents R1 and R2 denotes hydrogen or (C1-C4)-alkoxy, and the other denotes polyfluoro-(C1-C4)-alkoxy, and their pharmacologically-tolerated salts are suitable as bronchospasmolytic and cardiotonic active compounds. Processes for their preparation and appropriate medicaments are indicated.

专利号:US-2006211603-A1
优先权日:2004-08-18
标 题:Ramoplanin derivatives possessing antibacterial activity
发明人：RAJU BORE G; CIABATTI ROMEO; MAFFIOLI SONIA I; SINGH UPINDER; ROMANO GABRIELLA; MICHELUCCI ELENA; TISENI PAOLO S; CANDIANI GIANPAOLO; KIM BUM; O'DOWD HARDWIN
权利人:VICURON PHARM INC
摘要:Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

专利号:US-2013203709-A1
优先权日:2010-08-09
标 题 :Acylsulfonamides and processes for producing the same
发明人：MANETSCH ROMAN; KULKARNI SAMEER; IYAMU IREDIA D; WANG HONG-GANG; DOI KENICHIRO; GUIDA WAYNE; SANTIAGO DANIEL; DU BOULAY COURTNEY
权利人:MANETSCH ROMAN; KULKARNI SAMEER; IYAMU IREDIA D; WANG HONG-GANG; DOI KENICHIRO; GUIDA WAYNE; SANTIAGO DANIEL; DU BOULAY COURTNEY; PENN STATE RES FOUND; UNIV SOUTH FLORIDA
摘要:The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.

专利号:US-8524947-B2
优先权日:2008-02-22
标题 :Acylsulfonamides and processes for producing the same
发明人：WANG HONG-GANG; MANETSCH ROMAN; HU XIANGDONG; KULKARNI SAMEER; SUN JIAZHI
权利人:WANG HONG-GANG; MANETSCH ROMAN; HU XIANGDONG; KULKARNI SAMEER; SUN JIAZHI; UNIV SOUTH FLORIDA; H LEE MOFFITT CANCER CT & RES
摘要:The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.