CAS: 452-78-8; 3-Fluoro-4-Methylphenol

该化合物是属于酚类的有机化合物,其特征为氟原子和附于苯环的甲基组,具体分别在3和4个位置上.该化合物的特点是其芳香结构,有助于其稳定性和反应性.它一般是无色的黄色液体或固体,视温度和纯度而定.氟原子的存在会增强它的化学特性,使其在核细胞替代反应中更具极性,并有可能增加其再活动性.3-氟-4-甲基酚在有机溶剂中可溶性,并显示水中的溶性.它被用于各种用途,包括作为药物,农业化学品和其他有机化合物合成的中间体.在处理该物质时,应采取安全防范措施,因为如果浸泡或吸入,可能会对健康造成危害,而且应使用适当的保护设备.

结构式图片

相似化合物

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CAS号452-77-7 3-氟-4-甲基苯胺 | CAS号405-06-1 3-氟-4-甲基苯甲醚 | CAS号1427-07-2 2-氟-4-硝基甲苯 | CAS号394-42-3 2-氟-4-甲氧基苯甲酸 | CAS号405-06-1 3-氟-4-甲基苯甲醚 | CAS号83341-28-0 5-氟-4-甲基-2-硝基苯酚 | CAS号920525-52-6 2-fluoro-6-hydr... | CAS号504414-06-6 4-氟-2-羟基-5-甲基苯甲醛

合成工艺路线路线简述

    3-氟-4-甲基苯胺置于tetrafluoroboric Acid,Sodium Nitrite体系中,化学反应生成 3-氟-4-甲基苯酚
    参考文献:Brown Et Al.,Journal Of The Chemical Society,1949,P. Spl. 113
    标题:Brown Et Al.,Journal Of The Chemical Society,1949,P. Spl. 113

    海关参考信息

    专利信息


    专利号:US-2013172553-A1
    优先权日:2009-11-25
    标题 :Chiral synthesis of isoxazolines, isoxazoline compounds, and uses thereof
    发明人:SIELECKI-DZURDZ THAIS; PRUITT JAMES
    权利人:SIELECKI-DZURDZ THAIS; PRUITT JAMES; CPSI STOCKHOLDER TRUST
    摘要:Processes for the chiral syntheses of isoxazolines and intermediates are described. Compounds prepared thereby, and methods of using the compounds are also described.

    专利号:US-9802952-B2
    优先权日:2013-07-15
    标 题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
    发明人:KOPETZKI DANIEL; MCQUADE DAVID TYLER; SEEBERGER PETER H; GILMORE KERRY
    权利人:MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V; MAX-PLANK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V
    摘要:The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C 1 -C 5 alcohol.

    专利号:US-7615300-B2
    优先权日:2005-08-30
    标 题 :Development of novel proton-conductive polymers for proton exchange membrane fuel cell (PEMFC) technology
    发明人:BAE CHULSUNG
    权利人:REGENTS UNIVERSITY AND COMMUNI
    摘要:New thermally and chemically stable sulfonic acid-containing polymers are synthesized via post-sulfonation of aromatic polymers. These new polymers provide unique benefits to proton exchange membrane fuel cell technology (“PEMFCâ€?). As a sulfonic acid moiety can be easily installed into an aromatic ring via electrophilic sulfonation, even in the presence of an electron-withdrawing substituent such as —F, rigid polymers consisting of aromatic rings at either the side chain or main chain can be prepared with a wide range of substituents and flexibility in properties. Novel synthetic procedures are provided for synthesis of the polymers.

    专利号:US-2019181348-A1
    优先权日:2017-09-27
    标题 :Branch point effect on structure and electronic properties of conjugated polymers
    发明人:BRIDGES COLIN R; WANG MING; FORD MICHAEL J; BAZAN GUILLERMO C; SEGALMAN RACHEL A
    权利人:UNIV CALIFORNIA
    摘要:Synthesis of lyotropic semiconducting polymers having novel side chains enabling control over crystalline fraction, crystalline orientation, and the unit cell (specifically the Ï€-stacking distance). Moving the branch point in the side chain further from the conjugated backbone not only retains the lyotropic liquid crystalline behavior as observed by UV-vis and POM, but also achieves reduced Ï€-stacking distance. This results in higher charge carrier mobility, reaching (in one or more examples) a mobility of at least 0.41 cm 2 V −1 s −1 when the polymers were non-aligned.

    专利号:US-2007276139-A1
    优先权日:2004-02-10
    标题:Substituted Pixyl Protecting Groups for Oligonucleotide Synthesis
    发明人:SONG QUANLAI; KHAMMUNGKHUNE SAK; ROSS BRUCE S; GRIFFEY RICHARD H
    权利人:SONG QUANLAI; KHAMMUNGKHUNE SAK; ROSS BRUCE S; GRIFFEY RICHARD H
    摘要:The present invention describes an improved hydroxyl protecting group of formula (1), wherein R 2 and R 7 are specified substituents and Q is O, S, NR 10 or N(Câ•?O)R 10 .

    专利号:US-9580409-B2
    优先权日:2011-11-07
    标 题:Modulators of opioid receptors and methods of use thereof
    发明人:MALCOLM SCOTT; BOWEN CARRIE; MELNICK LAURENCE; XIE LINGHONG
    权利人:SUNOVION PHARMACEUTICALS INC; SUNOVION PHARMACEUTICALS INC
    摘要:Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as pain, neurological disorders, psychiatric disorders, and neuromuscular disorders. Compounds provided herein modulate the activity of opioid receptor (e.g., μ-opioid receptor) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.
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    合成参考文献


    参考文献:10.1007/3-540-30439-8_83
    摘要:Springer Handbook of Enzymes. : Springer Berlin Heidelberg; 2006. 4-Cresol dehydrogenase (hydroxylating). 2006.
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