CAS: 486-35-1; 7,8-Dihydroxy-2H-Chromen-2-One

该化合物是主要从Daphne genus的树皮中提取的天然的coumarin衍生物,特别是Daphne mezereum,其特征是白色晶状外观,分子式为C10H8O4.Daphnetin展示了一系列生物活动,包括防炎,抗氧化剂和抗微生物特性,使其对药理学研究感兴趣.该化合物溶于乙醇和二甲基硫氧化物等有机溶剂,但水溶性有限.Daphenin的结构具有氢氧基体和甲氧基化合物的特征,有助于其与各种生物目标的再活动及潜在互动.此外,还对其潜在的治疗应用进行了研究,包括其在调控与炎症和癌症有关的信号路径方面的作用.与许多自然化合物一样,有必要进一步研究,以充分阐明其行动和可能的临床用途机制.

结构式图片

欧盟法规

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上下游产品

CAS号617-48-1 DL-苹果酸 | CAS号87-66-1 1,2,3-苯三酚 | CAS号104819-86-5 7,8-dibenzyloxy... | CAS号471-25-0 丙炔酸 | CAS号2445-80-9 瑞香素二甲醚 | CAS号19492-03-6 8-羟基-7-甲氧基香豆素 | CAS号76474-93-6 7-methoxy-8-(3-... | CAS号108-24-7 乙酸酐 | CAS号110-16-7 马来酸 | CAS号2067-86-9 7-Hydroxy-2-oxo... | CAS号19492-03-6 8-羟基-7-甲氧基香豆素 | CAS号2445-80-9 瑞香素二甲醚 | CAS号21784-71-4 2H-1-Benzopyran... | CAS号76474-93-6 7-methoxy-8-(3-... | CAS号483-92-1 10-甲氧基-8,8-二甲基-... | CAS号485-90-5 7-羟基-8-甲氧基香豆素

合成工艺路线路线简述

  • 合成目标产物 7,8-Dihydroxycoumarin 主要起始原料 Propiolic Acid And Pyrogallol
  • (文献来源)合成步骤主要原料 Propiolic Acid 和 Pyrogallol
瑞香素-7-甲醚置于氢碘酸体系中,用 溶剂黄146 作为反应溶剂,化学反应 2.0H,反应生成 瑞香素
参考文献:Coumarins In Artemisia Caruifolia
标题:Coumarins In Artemisia Caruifolia
摘要:
DOI:10.1016/s0031-9422(00)82232-3

海关参考信息

专利信息


专利号:US-7598291-B2
优先权日:2004-09-02
标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
发明人:NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-2010160244-A1
优先权日:2004-09-02
标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin
发明人:NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-6150403-A
优先权日:1997-10-14
标 题 :Topical compositions for regulating the oily/shiny appearance of skin
发明人:BIEDERMANN KIMBERLY A; SCHUBERT HARRY L; PARRAN JR JOHN J
权利人:PROCTER & GAMBLE
摘要:The present invention relates to methods for inhibiting sebaceous gland activity in mammalian skin comprising administration of a topical composition comprising dehydroacetic acid or pharmaceutically acceptable salts thereof, and a dermatologically-acceptable carrier. The present invention also relates to methods and topical compositions further comprising agents which regulate the oily and/or shiny appearance of skin, and agents which treat acne and related skin disorders in mammalian skin and scalp. Methods of reducing sebum synthesis with the use of dehydroacetic acid, methods of regulating the oily and/or shiny appearance of skin, and methods of treating acne and other skin disorders are also encompassed by the present invention.

专利号:US-2007232495-A1
优先权日:2006-03-24
标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

专利号:US-8673983-B2
优先权日:2007-12-21
标题:Melanins synthesized chemically or via enzyme catalysis
发明人:HOLMES EARLE W; THOMPSON KENNETH D
权利人:HOLMES EARLE W; THOMPSON KENNETH D; UNIV LOYOLA CHICAGO
摘要:The present invention provides an enzymatic and a chemical synthesis of melanins and novel melanins.

专利号:CN-111039910-A
优先权日:2019-12-31
标题 :A kind of method and application of photo-initiated synthesis of 3-aryl flavonoids or coumarin compounds
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主要参考文献


1: Gao J, Chen F, Fang H, Mi J, Qi Q, Yang M. Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice. Biol Res. 2020 Oct 20;53(1):48. doi: 10.1186/s40659-020-00316-0.
2: Hang S, Wu W, Wang Y, Sheng R, Fang Y, Guo R. Daphnetin, a Coumarin in Genus Stellera Chamaejasme Linn: Chemistry, Bioactivity and Therapeutic Potential. Chem Biodivers. 2022 Sep;19(9):e202200261. doi: 10.1002/cbdv.202200261. Epub 2022 Aug 17.
13:993562. doi: 10.3389/fphar.2022.993562.

合成参考文献


参考文献:10.4268/cjcmm20110725
摘要:Chen L, Di L, Liu H, Shan J, Zhao X, Zhou W, Cai B. [Effects of glycyrrhiza extract on pharmacokinetics property of daphnetin in rats]. Zhongguo Zhong Yao Za Zhi. 2011 Apr;36(7):935–8.
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